Immuno 8: Effectors of Humoral Immunity

Question 1

Humoral immunity

Answer 1

Host defense mediated by secreted antibodies

Question 2

Plasma cells

Answer 2

Antibody secreting B lymphocyte

Question 3

Protective antibodies are produced during the _____ response to a microbe and in larger amounts during ________ responses

Answer 3

Protective antibodies are produced during the first (primary) response to a microbe and in larger amounts during subsequent (secondary) responses

Question 4

Antibody production begins within [time frame] of vaccination

Answer 4

The first week

Question 5

Memory B cell

Answer 5

Lies in wait. If it encounters antigen the rapidly diffentiate into antibody producing cells and start producing antibodies

Question 6

Antibody region that binds to antigen

Answer 6

Fab region

Question 7

Region of antibody that activates effector mechanism to eliminate antigen

Answer 7

Fc region

Question 8

Changes that occur in antibodies produced by B cells

Answer 8

Class switching and affinity maturation

Question 9

Neonatal Fc receptor (FcRn) location of expression and function

Answer 9

Expressed in placenta, endothelium, phagocytes and other cell times.

FcRn transports maternal antibodies to fetus circulation

Question 10

How does maternal IgG avoid degredation in fetus

Answer 10

binds to FcRn and recycled back into circulation

Question 11

Opsonization

Answer 11

Antibodies coat microbes to promote ingestion by phagocytes

Question 12

Opsonin

Answer 12

Molecule that coats microbe to enhance phagocytosis

Question 13

Phagosome

Answer 13

Vesicle formed from phagocytosis. Fuses with lysosome

Question 14

Organ where phagocytes live and work

Answer 14

Spleen

Question 15

Antibody-mediated phagocytosis is major defense mechanism against

Answer 15

Encapsulated bacteria

Question 16

Population susceptible to encapsulated bacteria infection

Answer 16

Spleenless mfs

Question 17

FcγRIIB

Answer 17

Fcy receptor that acts as anti inflammatory. Acts as feedback inhibition of B Cell activation

Question 18

Fcy receptor of natural killer cells

Answer 18

FcyRIII (CD16)

Binds to IgG antibodies on cell surfaces (e.g. viral glycoproteins).
This causes granule release from NK cell which induces apoptosis

Question 19

IgE normally binds to

Answer 19

worms

Question 20

Three complement activation pathways

Answer 20

Alternative
Classic
Lectin

Question 21

Alternative and lectin pathways are effector mechanisms of _______ immunity

Answer 21

Innate

Question 22

Classical pathway is a mechanism of __________ immunity

Answer 22

Adaptive humoral

Question 23

C3b

Answer 23

Complement system opsonin

Question 24

C5 complement protein function

Answer 24

Intiates C5-6-7-8-9 membrane attack complex

Question 25

C3a and C5a function to promote

Answer 25

Neutrophil chemotaxis, inflammation

Question 26

C1 INH

Answer 26

Early stopper of complement cascade

Question 27

Heriditary angioedema caused by ______

Answer 27

C1 INH defficiency Increased proteolytic activation of bradykinin causes fluid leakage -> increased edema

Question 28

Paroxysmal nocturnal hemoglobimuria

Answer 28

Unregulated complelement activation causes protein lysis

Question 29

IgA produced in

Answer 29

Mucosal lymphoid tissues

Question 30

IgA purpose

Answer 30

Binds to microbes to prevent them from colonizing through membranes