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PBL 2: Remediation Boogaloo > Pharm 10: Cholinergic Pharm > Flashcards

Pharm 10: Cholinergic Pharm Flashcards

1
Q

Muscarinic acetylcholine receptor type and location

A

G-protein

All parasympathetics, few sympathetics, CNS

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2
Q

Nicotinic Acetylcholine receptor type and location

A

Ligand gated

Post synaptic in excitatory ANS

Presynaptic in CNS

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3
Q

Acetylcholine synthesis _____+______= acetylcholine

what enzyme?

A

Acetyl CoA+ Choline

Choline acetyltransferase

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4
Q

How does choline get into neuron

A

NA+/Choline co-transporter

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5
Q

How does choline get into vesicle

A

AcH/H+ cotransporter

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6
Q

Hemicholinium-3 mechanism

A

Stops choline from entering the neuron (inhibits Na+/Choline transporter)

AcH can’t be synthesised

Anticholinergic

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7
Q

Vesamicol mechanism

A

Inhibits H+/ACh antiporter meaning AcH can’t get into vesicle

Anticholinergic

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8
Q

Muscarinic receptor type

A

G-protein coupled

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9
Q

Nicotinic receptor type

A

Ligand-gated ion channel

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10
Q

Muscarinic M1 Receptor location and response

A

Autonomic ganglia/CNS

Arousal, analgesia, late excitatory postsynaptic potential

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11
Q

Muscarinic M2 receptor location and response

A

Heart

Decreased conductivity, conduction velocity and contractility

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12
Q

Muscarinic M3 receptor location and response

A

Smooth muscle, contraction

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13
Q

Muscarinic M4 location and response

A

CNS

Presynaptic autoreceptor. Feedback inhibittion to suppress ACh release

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14
Q

Nicotinic Nm receptor location and response

A

Skeletal muscle neuromuscular junction

Depolarization and muscle contraction

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15
Q

Nicotinc Nn receptor location response

A

Autonomic ganglia, adrenal medulla, CNS

Depolarization of postganglionic neuron, catecholamine secretion, arousal/attention/analgesia

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16
Q

Ach is degraded by

A

AChE acetylcholinestarese

BuChE psyedocholinesterase

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17
Q

Hexamethonium MOA

A

antagonizes AcH causing rapid tetanic fade

18
Q

Atropine MOA

A

antimuscarinic agent resulting in vagal blockade and subsequent tachycardia

19
Q

Methacholine MOA and use

A

Muscarinic receptor agonist… used to diagnose asthma and as a vagomemetic

20
Q

Reticular activating system

A

Cholinergic neurons that keep you awake

Benadryl make u sleeypy

21
Q

Pirenzipine use

A

Muscarinic M2/M3 blockade

Decreased GI motility for some reason

22
Q

Physostigmine MOA and use

A

AChE inhibitor

Used for anticholinergic overdoses

23
Q

Neostigmine MOA and use

A

AChE inhibitor

Used for GI motility, glaucoma

24
Q

Edrophonium MOA and use

A

Rapid and reversible AChE blocker

Used to diagnose myasthenia gravis

25
Q

Pralidoxime MOA

A

Binds to organophosphate deactivated AChE

antidote

26
Q

Chronic myasthenia gravis treatments

A

long acting AChE inhibitors

pyirdostigmine, neostigmine

27
Q

Why is physostigmine used for anticholinergic poisoning

A

CNS penetrance

28
Q

Drugs used for alzheimers

A

Donepezil, rivastigmine, galantamine

29
Q

Which alzeheimers drugs can also treat parkinsons

A

Rivastigmine

30
Q

Carbachol MOA and use

A

Muscarinic agonist

used for glaucoma

31
Q

Bethanechol MOA and used

A

Muscarinic agonist. Used to promote GI/urinary motility

32
Q

Pilocarpine MOA and use

A

Miotic and saliva producing agent

33
Q

Cevilimine MOA and use

A

M1/M3 agonist for xerostomia in Sjörgen syndrome

34
Q

Succynicholine

A

THE S U C C

depolarizing blockade of nicotinic receptors

35
Q

Scopalamine use and MOA

A

Muscarinic antagonist

used for motion sickness

36
Q

Methscopolamine and glycopyrrolate

A

Quaternary amine antimuscarinics used to decrease GI spasms and oral secretions

Glycoporrolate also prevents bradycardia (atropine pre medication style)

37
Q

Ipatropium MOA

A

Muscarinic antagonist

38
Q

Non depolarizing agents

A

Veccoronium

Pancoronium

Roccoronium

39
Q

Non depolarizing antidote MOA

A

Sugammadex

forms complexes with vecc/rocc

40
Q

Benzotropine and Trihexyphenidyl MOA and use

A

M1 receptor antagonists. Balances dopamine with ACh

Good for parkinsons

41
Q

Ipatroprium receptor

A

M3

PBL 2: Remediation Boogaloo (24 decks)

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