Immuno 11: Hypersensitivity Flashcards

1
Q

Type 1 hypersensitivity

A

allergy caused by IgE mast cell activation

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2
Q

Type 2 hypersensitivity

A

Antibodies directed against cells or tissues, impairing function

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3
Q

Type 3 hypersensitivity

A

Antibodies against soluble antigens form complexes and deposit in blood vessels, causing inflamation and tissue injury

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4
Q

Type 4 hypersensitivity

A

T lymphocytes specific for self antigens attack tissues

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5
Q

Atopy

A

synonym for allergy

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6
Q

Sequence of events in development of immediate hypersensitivity reactions

A

Activation of Th2/IL-4helper t cells in response to antigen

Production of IgE by Th2/IL-4

IgE binds to mast cells leading to activation

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7
Q

Late-phase reaction

A

Part of mast cell activation. Comes from neutrophil and eosinophil recruitment. Repeated bouts can cause tissue injury

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8
Q

IL-4 secreted by ____ stimulates _____ to switch to IgE producing plasma cells

A

IL-4 secreted by Tfh cells stimulates B lymphocytes to switch to IgE producing plasma cells

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9
Q

Histamine function

A

Increased vascular permeability, vasodilation, contraction of smooth muscle

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10
Q

Arachidonic acid metabolites are released by

A

Mast cells

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11
Q

Arachidonic acid metabolites include

A

Prostaglandins and leukotrienes

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12
Q

Proteases released by mast cells cause

A

Tissue damage

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13
Q

Cytokines produced by mast cells stimulate the recruitment of_______, which cause the _________.

A

Cytokines produced by mast cells stimulate the recruitment of leukocytes, which cause the late-phase reaction.

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14
Q

Hay fever

A

Allergic rhinitis and sinusitis caused by pollen

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15
Q

Most common cause of asthma

A

Respiratory allergy in which inhaled allergens stimulate bronchial mast cells to release mediators like leukotrines which cause bronchial constriction

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16
Q

What class of Ig causes type 2 hypersensitivity

A

IgG

17
Q

Glomerulonephritis hypersensitivity type

A

3

18
Q

Cross reaction hypersensitivity type

A

Type 2

19
Q

Therapy for type 2 hypersensitivity reactions

A

Limiting of imflammation with drugs like corticosteroids

20
Q

Arthus reaction

A

Subcutaneous adminstration of protein antigen to previously immunized animal results in formation of immune complexes at site of antigen injection

type 3 hypersensitivity

21
Q

Hypersensitivity reaction limited to a tissue type

A

type 4

22
Q

Delayed type hypersensitivity AKA

A

Type 4

23
Q

Therapy for t cell hypersensitivity

A

Reduce inflammation and inhibit t cell response