pedigree analysis Flashcards
are often used to determine the mode of inheritance (dominant, recessive, etc.) of genetic diseases.
PEDIGREE
A very important tool for studying human inherited diseases
PEDIGREE ANALYSIS
—– means inherited on chromosome 1-22
Autosomal
——- means inherited on either X or Y chromosome.
sex-linked
→ Trait is rare in the pedigree
→ Trait often skips generations
(hidden in heterozygous carriers)
Autosomal recessive
→ Males are more often affected
than females
→ Trait is rare in pedigree.
→ Females are carriers
● X-linked recessive pedigrees
→ Trait is common in pedigree
→ passed to ALL of their daughters
→ Males and females are equally
likely to be affected
● X-linked dominant pedigrees
→ Traits on the Y chromosome are
only found in males, never in
females.
→ The father’s traits are passed to XY
on all sons.
Y-Linked Inheritance