Pediatrics Flashcards

1
Q

CC: “Our little boy is sick and getting worse.”

HPI: BW is a 22-month-old child brought to the Peds ER by his parents at 11:30 pm on 12/14. BW’s dad is a medical resident at the nearby orthopedic hospital, so he’s knowledgeable about the course of his son’s illness. He states that his son has had difficulty with asthma and allergies since he was 11 months old. He sees a pediatric pulmonologist. About 3 days ago, he noticed that his son had developed a mild cough and a runny nose. They used a humidifier and continued his regular meds. He seemed to be getting a little better. This morning the cough was noticeably worse, but the parents became very worried when his temp increased to 102.8 degrees Fahrenheit, and he began to have SOB about an hour ago. They came to the ER immediately.

Allergies: NKDA

PMH: Asthma and environmental allergies. Child is UTD on all vaccines.

Meds: Pulmicort Respules 0.25 mg BID at 0700 and 1600 via nebulizer and Singulair 4 mg daily at 2000

PE General Appearance: Child is febrile accompanied by concerned parents. Coughing continuously. Low O2 sats and developing stridor.

Labs:
CBC and chemistry pending
Lumbar puncture: Few RBCs, no WBC, no organism observed

Plan: Admit to medical floor for further work up and treatment.

BW’s father thinks his child should have a lumbar puncture. What disease is he concerned about?

a. Laryngotracheobronchitis
b. Meningitis
c. Respiratory syncytial virus
d. Enuresis
e. Polio

A

b

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2
Q

CC: “Our little boy is sick and getting worse.”

HPI: BW is a 22-month-old child brought to the Peds ER by his parents at 11:30 pm on 12/14. BW’s dad is a medical resident at the nearby orthopedic hospital, so he’s knowledgeable about the course of his son’s illness. He states that his son has had difficulty with asthma and allergies since he was 11 months old. He sees a pediatric pulmonologist. About 3 days ago, he noticed that his son had developed a mild cough and a runny nose. They used a humidifier and continued his regular meds. He seemed to be getting a little better. This morning the cough was noticeably worse, but the parents became very worried when his temp increased to 102.8 degrees Fahrenheit, and he began to have SOB about an hour ago. They came to the ER immediately.

Allergies: NKDA

PMH: Asthma and environmental allergies. Child is UTD on all vaccines.

Meds: Pulmicort Respules 0.25 mg BID at 0700 and 1600 via nebulizer and Singulair 4 mg daily at 2000

PE General Appearance: Child is febrile accompanied by concerned parents. Coughing continuously. Low O2 sats and developing stridor.

Labs:
CBC and chemistry pending
Lumbar puncture: Few RBCs, no WBC, no organism observed

Plan: Admit to medical floor for further work up and treatment.

The ER physician explains to the parents that he thinks BW’s presentation is most consistent with RSV. How is RSV generally managed in healthy older children?

a. Palivizumab
b. Vancomycin + cefotaxime
c. Dexamethosone + racemic epinephrine
d. Desmopressin
e. Supportive care

A

e

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3
Q

Which of the following groups of meds are generally not used in pediatric patients?

a. Iron, tetracyclines, morphine, and codeine
b. Tetracyclines, promethazine, acetaminophen, and fluoroquinolones
c. Codeine, iron, fluoroquinolones, and promethazine
d. Tetracyclines, codeine, promethazine, and fluoroquinolones
e. Morphine, promethazine, fluoroquinolones, and tetracyclines

A

d

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4
Q

An 8 y/o boy with enuresis will receive desmopressin tablets. Which of the following side effects is most likely?

a. Headache
b. Seizures
c. Insomnia
d. Skin photosensitivity/photophobia
e. Irritability/mood swings

A

a

Headache, fatigue, and possibly hyponatremia can occur; headache has the highest incidence (2-5%). These side effects are for the PO tablets. The nasal spray can cause other side effects, including rhinitis and epistaxis.

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5
Q

SA is a 2 y/o male child. His parents brought him to Urgent Care because he has had a gradual loss for appetite for 4 days. They say that he doesn’t want to get out of bed and seems tired during the day. SA’s mom says that he started to cry when she washed his during his bath today. She thought maybe his head hurt. Upon PE, his salivary glands are very swollen and tender to touch. What childhood illness is most likely in this case?

a. Varicella
b. Measles
c. Mumps
d. Polio
e. Pertussis

A

c

Swollen, tender salivary glands (parotitis) is emblematic of mumps. Many patients have very mild or no symptoms.

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6
Q

MW is a 4 y/o girl who has had a swollen right knee for the past few weeks. She can’t fully extend her leg and limped into the medical office. She weighs 28.6 pounds. Labs reveal an ESR of 12 mm/hr and report the ANA as positive. She receives a diagnosis of juvenile rheumatoid arthritis and is started on methotrexate and ibuprofen 10 mg/kg Q8H. The pharmacy has an ibuprofen suspension of 100 mg/5 mL. How many milliliters of ibuprofen suspension should be given every 8 hours?

a. 3 mL
b. 4 mL
c. 5 mL
d. 6.5 mL
e. 14.3 mL

A

d

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7
Q

An Rx is written for cefuroxime PO suspension 30 mg/kg/day divided BID x 10 days for a 7 y/o pt (weight 42 lbs). How many milligrams should the pt receive for each dose?

a. 72
b. 143
c. 286
d. 573
e. 630

A

c

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8
Q

RT is a 13 month-old child with a viral-induced fever. She’s 18.4 lbs and 28.8 inches. Her parents report that she has been fussy and irritable and feels “hot.” She has a fever of 39.4 degrees Celsius. Which of the following dosing recommendations for acetaminophen is correct for this child?

a. 80 mg Q2-4H PRN fever
b. 80 mg Q8-12H PRN fever
c. 100 mg Q4-6H PRN fever
d. 140 mg Q6-8H PRN fever
e. 184 mg Q4-6H PRN fever

A

c

The correct dosing of acetaminophen for infants (except neonates) and children is 10-15 mg/kg PO Q4-6H PRN.

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9
Q

DW is a 7 y/o male pt who has been prescribed Pediacare Children’s Cough and Runny Nose liquid (acetaminophen 160 mg/chlorpheniramine maleate 1 mg/dextromethorphan 5 mg per 5 mL). Which of the following are correct counseling points to give to DW’s dad?

a. Administer this med with a household teaspoon
b. Diphenhydramine is an expectant and will help DW cough up mucous
c. Chlorpheniramine is an antihistamine that can make DW more sleepy than normal
d. Minimize the amount of Children’s Tylenol given to DW while taking this med
e. Preferentially treat DW’s fevers with aspirin instead of Children’s Tylenol

A

c, d

Aspirin has been associated with Reye’s syndrome and shouldn’t be used in patients < 16 y/o.

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10
Q

A mom has a “colicky” newborn. He’s crying after she feeds him, which lasts about an hour. The child has been seen by the pediatrician who told the mom that the baby is fine and to use an OTC anti-gas agent. Which of the following products should be chosen?

a. Advil infant drops
b. Mylicon infant drops
c. Acetaminophen infant drops
d. Gaviscon infant drops
e. Phillips infant drops

A

b

Simethicone (Mylicon) infant drops help break up gas bubbles so that the baby can pass them out, which relieves pain. They aren’t absorbed, work safely, and provide a mild benefit. They are delivered via a dose calibrated dropper. Simethicone is taken after meals, and if needed, at bedtime.

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11
Q

Desmopressin is available in which of the following formulations?

a. Injection
b. Suppository, rectal
c. Nasal spray
d. Topical paste
e. Oral tablet

A

a, c, e

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12
Q

DJ is a 2 y/o boy being treated for otitis media. He’s going to receive an Rx for amoxicillin 90 mg/kg/day. He weighs 26 pounds and is 35 inches tall. How many milligrams of amoxicillin should be administered every 12 hours? Round to the nearest TEN milligrams.

A

530

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13
Q

Which of the following is correct about chickenpox?

a. It’s caused by rubella and prevented with the Boostrix vaccine.
b. It’s caused by human papillomavirus and prevented with the DTaP vaccine.
c. It’s caused by varicella zoster virus and prevented with the Shingrix vaccine.
d. It’s caused by rotavirus and prevented with the Rotarix vaccine.
e. It’s caused by varicella zoster virus and prevented with the Varivax vaccine.

A

e

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14
Q

A mom comes to the pharmacy asking for advice on something OTC to treat her daughter’s fever. Her daughter is 13 months old and weighs 11 pounds. Her rectal temp this morning was 39.7 degrees Celsius. The most appropriate recommendation is:

a. Monitor the child for another 24 hours to see if the fever subsides before treating OTC meds.
b. Recommend ibuprofen 25-50 mg Q6-8H.
c. Recommend acetaminophen 50-75 mg Q4-6H.
d. Recommend a cool bath to lower the child’s temp.
e. Seek medical care for the child immediately.

A

e

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15
Q

0-28 days

A

neonate

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16
Q

1 month-12 months

A

infant

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17
Q

1-2 years

A

toddler

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18
Q

2-12 years

A

child

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19
Q

13-18 years

A

adolescent

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20
Q

Match the age with its correct temperature that warrants urgent care for a child:

  1. < 3 months
  2. 3-6 months
  3. > 6 months

a. 101F / 38.3C
b. 103F / 39.4C
c. 100.4F / 38C

A
  1. c
  2. a
  3. b
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21
Q

What are the 4 safe practice recommendations when dispensing liquid medications that carry high risk?

A
  1. Stock only one strength if a dangerous drug comes in a variety of strengths. Place the container in a high-risk bin with instructions attached to the container.
  2. The dose should be written in terms of total mg and in mg/kg per dose.
  3. The pharmacist should check that the dose is appropriate for the child’s weight. Ask the caregiver for the child’s weight if it’s not available.
  4. The container label should include the dose (mg) and the volume (mL). Dispense with a measuring device.
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22
Q

Why is vitamin K given to newborns after birth?

A

to prevent bleeding

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23
Q

Low APGAR scores in preterm infants are usually due to what?

A

immature lung and heart development

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24
Q

What drugs can help close a PDA in a newborn?

A

NSAIDs (IV indomethacin)

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25
Q

NSAIDs must be administered within ______ of birth to be effective for closing a PDA.

A

14 days

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26
Q

Persistent pulmonary hypertension of the newborn (PPHN) may be linked to in utero ____ exposure.

A

SSRI

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27
Q

What drugs can be used for PPHN?

A

prostacyclin analogues and PDE-5 inhibitors

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28
Q

What causes respiratory distress syndrome (RDS)?

A

deficiency of surfactant production

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29
Q

Most babies born at < __ weeks gestation will receive surfactant immediately after birth or within the 1st few days of life.

A

35

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30
Q

“surf” or “actant”

A

surfactant products

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31
Q

Intestinal gas can be mildly relieved with what?

A

simethicone drops

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32
Q

Symptoms of intestinal gas will generally dissipate when child is around __-__ _______ old.

A

6-8 months

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33
Q

What things can reduce congestion in a child?

A
  • cool-mist humidifier near the bedside (especially in the winter)
  • sitting with the child in the bathroom while a hot shower creates steam in the room
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34
Q

Loosens mucus to provide congestion relief

A

suction with saline drops or spray

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35
Q

T/F: The FDA recommends OTC cough and cold medications in children >/= 1 year old.

A

False; the FDA does not recommend OTC cough and cold medications in children < TWO years old

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36
Q

Recommended for the treatment of intermittent constipation

A

polyethylene glycol 3350 (Miralax)

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37
Q

What fruits can be helpful for constipation?

A

prunes or pears

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38
Q

Commonly used for quick relief of constipation in an uncomfortable baby

A

glycerin suppositories

39
Q

Glycerin suppositories are FDA-approved for quick relief of constipation in what age?

A

2 years and older

40
Q

What age should aspirin and salicylates be avoided in and why?

A

< 16 y/o; they have been associated with Reye’s syndrome when used in children recovering from viral infections

41
Q

If a child has diarrhea, fluid and electrolytes should be replaced with what (name two examples)?

A

oral rehydration solutions (Pedialyte and Enfamil Enfalyte)

42
Q

Acetaminophen dose for children

A

10-15 mg/kg/dose Q4-6H
Max = 75 mg/kg/day

43
Q

Concentration for all acetaminophen PO liquid formulations

A

160 mg/5 mL

44
Q

Ibuprofen dose for children

A

5-10 mg/kg/dose Q6-8H
Max = 40 mg/kg/dose

45
Q

Ibuprofen is indicated for infants >/= _____________________.

A

6 months old

46
Q

If alternating between ibuprofen and acetaminophen for pain and fever relief, how many hours should the doses be separated by?

A

3 hours

47
Q

If using the same medication for pain and fever relief in a child, how long should the doses be separated by?

A

6 hours

48
Q

What is a key symptom of bacterial meningitis in neonates/infants?

A

nuchal rigidity (inability to bend the neck)

49
Q

A definitive diagnosis of bacterial meningitis can be made from what test?

A

lumbar puncture

50
Q

Common pathogens of bacterial meningitis in neonates

A

GBS
E. coli
Listeria
Klebsiella

51
Q

Empiric treatment of bacterial meningitis in neonates

A

ampicillin + cefotaxime or gentamicin

52
Q

Why should ceftriaxone be avoided for treatment of bacterial meningitis in neonates (2 reasons)?

A
  1. Ceftriaxone displaces bilirubin from albumin, which can cause kernicterus –> brain damage
  2. Ceftriaxone and calcium-containing solutions can precipitate, causing embolus and death
53
Q

Match the age with the common pathogens associated with bacterial meningitis:

  1. < 1 month
  2. 1-23 months
  3. 2+ years

a. GBS, E. coli, Listeria, Klebsiella
b. N. meningitidis, S. pneumoniae
c. S. pneumoniae, Neisseria meningitidis, S. agalactiae, H. influenzae, E. coli

A
  1. a
  2. c
  3. b
54
Q

Empiric treatment of bacterial meningitis in infants < 1 month

A

Ampicillin + cefotaxime
OR
Ampicillin + amino glycoside (gentamicin)

55
Q

Empiric treatment of bacterial meningitis in children > 1 month old

A

vancomycin + 3rd generation cephalosporin (ceftriaxone or cefotaxime)

56
Q

In patients with severe lower respiratory tract RSV infections with an underlying compromising condition (prematurity, cardiopulmonary disease, or immunosuppression), what treatment can be considered?

A

inhaled ribavirin (Virazole)

57
Q

Humanized monoclonal antibody indicated for the prevention of serious lower respiratory tract disease caused by RSV in children at high risk of the disease

A

palivizumab (Synagis)

58
Q

When is RSV season?

A

late fall, winter, and early spring

59
Q

How is palivizumab dosed?

A

monthly via IM injection

60
Q

Where is the IM injection site in neonates and infants?

A

anterolateral thigh muscle

61
Q

Infants should not receive more than __ monthly doses of Synagis during the RSV season.

A

5

62
Q

Who should receive palivizumab (Synagis) for RSV prophylaxis?

A
  1. Premature infants born at < 29 weeks gestation
  2. Premature infants born < 32 weeks gestation with chronic lung disease who are < 12 months of age
  3. Infants < 12 months of age with certain heart conditions
63
Q

Usually d/t a viral infection and causes inflammation of the upper airway, larynx, trachea, and bronchi

A

croup

64
Q

Hallmark signs of croup

A
  • inspiratory stridor (high pitched breathing sound)
  • barking cough
  • hoarseness
65
Q

What age group is croup most common in?

A

< 6 y/o

66
Q

Mainstay of croup treatment for mild, moderate, and severe cases

A

systemic steroids (dexamethasone)

67
Q

A child that presents to the an acute care setting with moderate to severe croup symptoms that has difficulty breathing will usually be given what 2 things?

A

a systemic steroid and nebulizer racemic epinephrine

68
Q

What is the active component of racemic epinephrine?

A

the L-isomer

69
Q

10 mg racemic epinephrine = __ mg L-epinephrine

A

5

70
Q

What should be tried first if a child exhibits nocturnal enuresis?

A

behavioral approaches

71
Q

What are examples of behavioral approaches for bed-wetting?

A
  • positive reinforcement
  • daytime voiding pattern
  • hydration pattern
72
Q

In a child with nocturnal enuresis

A
73
Q

In a child with nocturnal enuresis, if behavioral methods do not result in dryness, what can be tried next?

A

alarm therapy or alarm therapy with desmopressin

74
Q

Synthetic analog of antidiuretic hormone (ADH)

A

desmopressin

75
Q

Which formulation of desmopressin is used for enuresis?

A

oral tablet

76
Q

What formulations does desmopressin come in?

A

tablet, nasal spray, and injection

77
Q

Desmopressin enuresis dose

A

0.2 mg PO QHS

78
Q

Contraindication for desmopressin

A

hyponatremia

79
Q

Main side effect of desmopressin

A

headache

80
Q

Limit fluid intake starting __ _______ before desmopressin dose and until the next morning.

A

1 hour

81
Q

Match the drug with its correct age contraindication (some choices can be used twice):

  1. Codeine
  2. Tramadol
  3. Promethazine
  4. Ceftriaxone

a. < 2 years
b. < 12 years
c. Neonates (1-28 days)

A
  1. b
  2. b
  3. a
  4. c
82
Q

Codeine is metabolized to morphine via what CYP enzyme?

A

CYP2D6

83
Q

Contraindications for codeine in children (2)

A
  • children < 12 y/o
  • children < 18 y/o after tonsillectomy/adenoidectomy
84
Q

The FDA changed the labeling for all prescription cough and cold medications that contain codeine and hydrocodone, saying they are no longer indicated in patients < __ years old.

A

18

85
Q

Why are quinolones not recommended in children?

A

risk of adverse effects on cartilage, bone, and muscle

86
Q

Why are tetracyclines not recommended in children < 8 y/o?

A

they stain teeth and deposit into mineralizing (growing) bone and cartilage

87
Q

What is an exception for using tetracyclines in children < 8 y/o?

A

tick-borne Rickettsial diseases (Rocky Mountain spotted fever, ehrlichiosis, and anaplasmosis)

88
Q

What is the most effective for tick-borne Rickettsial disease?

A

doxycycline

89
Q

The FDA now recommends against the use of this agent in children < 2 y/o d/t the risk of methemoglobinemia.

A

benzocaine

90
Q

2 culprits of accidental overdose in children

A

iron and acetaminophen

91
Q

Match the vaccine-preventable childhood disease with its correct description:

  1. Measles
  2. Mumps
  3. Rubella
  4. Chickenpox

a. Itchy rash (crops of sores)
b. Swollen salivary glands
c. Fine, pink rash that begins on the face and quickly spreads to the rest of the body
d. Koplik spots in mouth, maculopapular rash

A
  1. d
  2. b
  3. c
  4. a
92
Q

Transmission of measles

A

airborne

93
Q

What do Koplik spots look like?

A

small, white spots on the inside of the cheeks