Cardiology Flashcards
contraindications of statins
pregnancy, breastfeeding
liver disease
CYP3A4 inhibitors - simvastatin and lovastatin
Vascepa generic name
icosapent ethyl
Zetia generic name
ezetimibe
Lovaza generic name
omega-3
Possible side effects of Lovaza include:
a. burping
b. arthralgias
c. dyspepsia
d. taste perversions
e. rhabdomyolysis
a, c, d
Which of the following can cause LDL to increase?
a. Tacrolimus
b. Niaspan
c. Lovaza
d. Dexamethasone
e. Welchol
F. Risperidone
a, c, d, f
Which of the following should be avoided with lovastatin?
a. Lopid
b. Voriconazole
c. Theophylline
d. Plavix
e. Biaxin
a, b, e
What are the max doses per day of simvastatin and lovastatin when used in combination with non-DHP CCBs?
simvastatin 10 mg
lovastatin 20 mg
Which statin is the least potent?
fluvastatin
For cholestyramine or colestipol, take all other meds at least ______ hours before or _______ hours after.
1-4; 4-6
Elevated TGs are most likely to cause what?
pancreatitis
Which statin should be taken with an evening meal?
lovastatin IR
Which of the following will help to lower TG?
a. Lovaza
b. Trilipix
c. TriCor
d. Vascepa
e. Welchol
a, b, c, d
What is a key counseling point for ER niacin administration?
Take at bedtime after a low fat snack
Select the correct MOA of cholestyramine.
a. Reduces cholesterol absorption at the brush-border
b. Peroxisome proliferator receptor alpha activator
c. Increases HDL synthesis
d. Inhibits the enzyme HMG-CoA reductase
e. Bind to bile acids in the gut
e
What drugs increase TG only?
IV lipid emulsions, propofol, bile acid sequestrants
When combined with simvastatin, which of the following increases the risk of myalgias?
a. Niacin 1 g daily
b. Colesevelam
c. Red yeast rice
d. Fenofibrate
e. Rifampin
a, c, d
T/F: Formulations of niacin (IR vs ER) are interchangeable.
F
What other names is niacin known by?
vitamin B3, nicotinic acid
Welchol is approved for use in which of the following conditions?
a. RA
b. Diabetes
c. Gout
d. Hypertriglyceridemia
e. Crohn’s disease
b
What cholesterol meds increase bleeding risk?
fish oil
Which of the following effects do statins have on cholesterol values?
a. Raises HDL
b. Lowers HDL
c. Raises TG
d. Lowers LDL
e. Lowers TG
a, d, e
What is the MOA of ezetimibe?
inhibits the absorption of cholesterol in the small intestine
Which statins can be given at any time of the day? (5)
Crestor, Lipitor, Livalo, Lescol XL, Pravachol