Pathoma Vulva, Vagina And Cervix Flashcards
3 things to remember about the clinical presentation of a bartholin cyst?
Unilateral, painful and adjacent to vaginal canal
What is the typical patient presenting with lichen sclerosis?
Postmenopausal women
Very important, of lichen sclerosis and lichen simplex chronicus (or hyperplasia), which one has the chance to progress to squamous cell carcinoma?
Lichen sclerosis
What is extra mammary pagets disease?
Malignant cells found in the epidermis of the vulva.
3 clinical signs of Paget’s disease of the vulva?
Red, itchy and ulcerated
What is the difference between Paget’s disease in the vulva and in the nipple?
Vulva has no underlying carcinoma
Nippled there is usually an underlying carcinoma
Paget’s disease in the vulva must be distinguished from what other disease and what 3 things allow us to do that?
Melanoma
Paget’s disease will be PAS positive, keratin positive and s100 negative
Explain what keratin is and why it is important to know for the purposes of what cancer is present?
Intermediate filament in epithelial cells, so if something is keratin positive it is usually a carcinoma.
Not sarcoma, lymphoma, or melanoma
What is PAS staining for and what does that tell us?
Stinking for mucus producing cells/tissue basically, so carcinomas
There is an increased incidence of adenosis in women who were exposed to what? Adenosis is associated with the development of what in the vagina?
DES
Clear cell adenocarcinoma
What is the characteristic cell of a embryonal rhabdomyosacroma and what two things stain positive in immunochemical staining?
Rhabdomyoblast
Desmin and myogenin
One classic/key clinical sign of cervical carcinoma?
Vaginal bleeding, especially after sex
Two secondary risk factors to cervical carcinoma after HPV?
Smoking and being immunocompromised
What does the quadrivalent vaccine for HOV cover, what types? Even though women get the vaccine, do they still need to get a Pap smear?
6,11,16, and 18
Yes, because there are so many types out there.
