Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Repo 2 > Endometrial Lesions and Tumors > Flashcards

Endometrial Lesions and Tumors Flashcards

1
Q

How do we define endometrial hyperplasia and what causes it?

A

Hyperplasia of the glands relative to stroma and due to unopposed estrogen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Classic presenting patient of endometrial hyperplasia and what is the presenting sign?

A

Obese post menopausal women

Post menopausal bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

5 conditions that lead to increased estrogen?

A

Anovulation, obesity, menopause, estrogen replacement therapy, and polycystic ovarian syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the most important predictor for progression to carcinoma of endometrial hyperplasia?

A

Cellular atypia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is a common genetic alteration in both endometrial hyperplasia and endometrial carcinoma?

A

Inactivating PTEN tumor suppressor gene.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is Cowden Syndrome?

A

Germ line PTEN mutations leading to a high incidence of endometrial and breast cancer.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Loss of PTEN leads to over activation of what?

A

PI3/AKT pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cardinal histo feature of non atypical hyperplasia?

A

Increased gland to stroma ratio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is another name for atypical hyperplasia and what is the histo for atypical?

A

endometrial intraepithelial neoplasia.

Complex patterns of proliferating glands showing nuclear atypia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Endometrial carcinoma is the most common what in women?

A

Invasive carcinoma of the female genital tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the early clinical sign of endometrial carcinoma?

A

Post menopausal bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the two pathways that lead to endometrial carcinoma?

A

Hyperplasia and sporadic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Explain the patho of the hyperplasia pathway and what is the classic histo feature?

A

Unopposed estrogen causing hyperplasia until carcinoma.

Endometrioid, which is endometrium like looking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does the sporadic pathway occur and what is the classic histo?

A

Carcinoma from an atrophic endometrium.

Serous and papillary structures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Classic presenting age of type 1 endometrial carcinoma, besides unopposed estrogen what are three other clinical conditions associated with type 1, what is the most common mutation and pathway?

A

60
Diabetes, HTN, and obesity
PTEN via PI3/AKT pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Presenting age, clinical condition, morph feature, mutation and behavior of type 2 or sporadic?

A 
70
Atrophy
Serous
P54
Aggressive
17
Q

What is a psammoma body and which endometrial cancer type do we find it in?

A

Death of the papillary projection leading to concentric calcification.
Type 2

18
Q

What other cancer in this section has psammoma bodies?

A

Papillary thyroid carcinoma

19
Q

What is stage 1 of endometrial cancers? Stage 2? Stage 3? Stage 4?

A
  1. Cancer in the corpus only
  2. Corpus and cervix
  3. Outside the uterus but not pelvis
  4. Outside pelvis and into bladder or rectum
20
Q

what is a carcinosarcoma?

A

Malignant glandular and mesenchymal elements

Repo 2 (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions