Ovarian Sex Cord Stromal Tumors

Question 1

What are the three sex cord stromal tumors?

Answer 1

Granulosa theca cell tumor, sertoli-leydig cell tumor, and fibromyalgia

Question 2

What is the hormone produced by granulosa theca cell tumors?

Answer 2

Estrogen

Question 3

What would the patient present with if they had a granulosa theca cell tumor before puberty? During Reproductive age? Postmenopausal?

Answer 3

They would have early puberty
Heavy menstrual bleeding
Postmenopausal bleeding (most common setting)

Question 4

What is characteristic on histo of a ssertoli-leydig cell?

Answer 4

Reinke crystal

Question 5

What hormone will sertoli-leydig cells produce and what two complications can happen in women?

Answer 5

Androgen.

Hirsutism and virilization

Question 6

What syndrome is associated with a fibroma in the ovary and what is the clinical triad?

Answer 6

Meigs syndrome

Pleural effusion, ascites and fibroma.

Question 7

What is a kruckenburg tumor in the ovary?

Answer 7

Metastatic mucinous tumor that involves both ovaries. Classically spreading from a gastric carcinoma that is the diffuse type

Question 8

What are two features of diffuse type gastric carcinoma to remember?

Answer 8

Linitis plastica and signet rings

Question 9

What is a tool to help us know if it is a primary mucinous tumor or metastatic mucinous tumor?

Answer 9

Metastatic is bilateral

Question 10

What is pseudomyxoma peritonei and what does it have to do with the ovary?

Answer 10

Tons and tons of mucus in the abdominal cavity usually due to a primary mucinous carcinoma of the appendix. Can spread to the ovary.