Pathology - Thyroid Flashcards
2 benign thyroid nodules?
colloid nodule
follicular adenoma
why do FNA vs. core biopsy for thyroid?
lots of bleeding
what are some malignant causes of thyroid nodules?
papillary carcinoma
follicular carcinoma
medulary carcinoma
anaplastic carcinoma
multinodule goitre histo?
fibrosis
not well defined capsule
will get more colloid on FNA
follicular adenoma histology?
microfollicles
well defined thin capsule around it
FNA on follicular adenoma, will get more cells or colloid?
more cells
what is the most common malignant thyroid nodules?
papillary carcinoma (85%)
papillary carcinoma well defined capsule?
no
papillary carcinoma histo?
finger-like projections from the fibrous cores
papillary carcinoma histo architecture?
crowded enlarged nuclei “basket of eggs”
nuclear grooves
what histo is unique to papillary carcinoma
Psammomatous body - microcalcifications
follicular carcinoma vs. adenoma?
larger
thicker capsule
evidence of invasion
medullary carcinoma
C-cell derived (caltonin)
associated with MEN2
RET oncogene mutation
amyloid deposition
what kind of cancer arises from thyroid C-cells?
medullary carcinoma
what is the worst kind of tumour of thyroid?
anaplastic carcinoma
basic thyroid FNA principles?
more colloid: likely benign
more cells: likely be malignant
FNA can’t differentiate?
follicular adenoma
follicular carcinoma
why total thyroidectomy for malignant thyroid?
papillary are multi-focal
category IV for follicular neoplasms are what cancers?
adenoma or carcinoma
malignant thyroid cytology in cells look like what?
coffee bean
nuclear pseudo-inclusions
most common thyroid cancer? (85%)
papillary thyroid carcinoma
who gets papillary thyroid carcinoma?
age 25-50
papillary thyroid carcinoma risk factor?
radiation exposure
papillary thyroid carcinoma one or more nodule presentation?
usu. one nodule
papillary thyroid carcinoma prognosis?
95% 10yr survival
Neck Lump differential
tumour cyst parathyroid metastases lymph node salivary lesion
