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Jason's MD2 ED/Amb Rotation > Pathology - Thyroid > Flashcards

Pathology - Thyroid Flashcards

1
Q

2 benign thyroid nodules?

A

colloid nodule

follicular adenoma

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2
Q

why do FNA vs. core biopsy for thyroid?

A

lots of bleeding

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3
Q

what are some malignant causes of thyroid nodules?

A

papillary carcinoma
follicular carcinoma
medulary carcinoma
anaplastic carcinoma

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4
Q

multinodule goitre histo?

A

fibrosis
not well defined capsule
will get more colloid on FNA

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5
Q

follicular adenoma histology?

A

microfollicles

well defined thin capsule around it

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6
Q

FNA on follicular adenoma, will get more cells or colloid?

A

more cells

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7
Q

what is the most common malignant thyroid nodules?

A

papillary carcinoma (85%)

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8
Q

papillary carcinoma well defined capsule?

A

no

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9
Q

papillary carcinoma histo?

A

finger-like projections from the fibrous cores

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10
Q

papillary carcinoma histo architecture?

A

crowded enlarged nuclei “basket of eggs”

nuclear grooves

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11
Q

what histo is unique to papillary carcinoma

A

Psammomatous body - microcalcifications

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12
Q

follicular carcinoma vs. adenoma?

A

larger
thicker capsule
evidence of invasion

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13
Q

medullary carcinoma

A

C-cell derived (caltonin)
associated with MEN2
RET oncogene mutation
amyloid deposition

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14
Q

what kind of cancer arises from thyroid C-cells?

A

medullary carcinoma

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15
Q

what is the worst kind of tumour of thyroid?

A

anaplastic carcinoma

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16
Q

basic thyroid FNA principles?

A

more colloid: likely benign

more cells: likely be malignant

17
Q

FNA can’t differentiate?

A

follicular adenoma

follicular carcinoma

18
Q

why total thyroidectomy for malignant thyroid?

A

papillary are multi-focal

19
Q

category IV for follicular neoplasms are what cancers?

A

adenoma or carcinoma

20
Q

malignant thyroid cytology in cells look like what?

A

coffee bean

nuclear pseudo-inclusions

21
Q

most common thyroid cancer? (85%)

A

papillary thyroid carcinoma

22
Q

who gets papillary thyroid carcinoma?

A

age 25-50

23
Q

papillary thyroid carcinoma risk factor?

A

radiation exposure

24
Q

papillary thyroid carcinoma one or more nodule presentation?

A

usu. one nodule

25
Q

papillary thyroid carcinoma prognosis?

A

95% 10yr survival

26
Q

Neck Lump differential

A 
tumour
cyst
parathyroid
metastases
lymph node
salivary lesion

Jason's MD2 ED/Amb Rotation (37 decks)

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