Diarrhoea in a Young Man Flashcards
diarrhoea characterization?
what's their normal? consistency colour volume: small bowel: larger volume mucous? blood? (more large bowel)
urgency with diarrhoea important how?
tenaesmus,
proctitis
rectal inflammation
mass in colon?
associated features?
vomiting?
abdo pain?
tenaesmus
diarrhoea at night means?
infammatory, not osmotic
types of diarrhoea presentation?
large vs. small
osmotic vs. secretory
why stool loose?
secretion
not absorbing
increasing transit time
giardia affects where? presentation?
small bowel
no blood
what parasitic infection causes bloody diarrhoea?
entamoeba histolytica
hypoalbuminia sign of malnutrition?
not really, need BMI of
why do you get hypoalbuminia in inflammatory diarrhoea?
negative acute phase reactant
first line treatment for Ulcerative colitis?
5 Amino-slycylic acid and pred
long term risks of ulcerative colitis?
bowel cancer
risks of ileal pouch?
pouchitis
can still get bowel cancer
long term effects of 5ASA
azoospermia
azathioprine used in what?
Crohn’s, not UC
what biologic for UC?
infliximab
reactive arthritis?
immune mediated reaction to joint
what can cause reactive arthritis?
gonorrhoea, campylobacter, yersinia
what can cause a bad flair of Ulcerative colitis?
CMV/amoebic superinfection on top of UC
why do daily x-ray in UC exacerbation?
monitor for toxic megacolon
azathioprine works how?
works on T-cells
azathioprine»6MP» active metabolite (6TGN) + toxic metabolite, give allopurinol to shunt pathway to active metabolite
what tests to do before starting azathioprine
TB vaccinations virals liver function pregnancy test? kidney function
rescue therapy for UC?
infliximab (TNF-a)
cyclosporine
emergency toxic megacolon treatment?
colectomy
diarrhoea definition
increased freq or
reduced consistency
