path of CAD Flashcards
main cardiac cause of death in USA
80% coronary ischemic heart disease. also congee, valve, HTN
clin of CAD
angina pectoris, MI, chronic ischemic, sudden death
types of angina pectoris
chronic stable, prinz, unstable crescendo
risk factors for CAD
smoking, HTN, smoking, age, SM, obesity, FH, sex
path of MI
acute plaque change> block vessel
types of infarction
transmural, subendocardial, multifocal
transmural
entire wall (endo>episode), most common, usually LAD, right, or Lcx
subendocardial
inner 1/3 have LU, usually circumflex, mult vessels. hypoerfusion, shock
micro changes 24 hours
wavy fibers, contraction nabs necrosis, eosinophilic myocyes,
24 hr macro
cut surface pallor, dark motility
2-4 day micro
PNMs, interstitial edema/hemm, no nuclei, loose striation
2-4 day macro
rotting with yellow/tan
7-10 day micro
few PNM, Mphage, fblast/collogen, lymphcoytes
7-10 macro
sharp hyperemic outline, central necrotic region (pale, gelat)
2-8 week micro
granulation tissue, blast, chronic inflam