cardiac muscle mechanics Flashcards

1
Q

co=

A

HR*SV

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2
Q

SV=

A

EDV-ESV

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3
Q

ESV

A

amount remaining in heart after systole

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4
Q

EDV

A

amount filled

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5
Q

what affects EDV

A

preload

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6
Q

what affects ESV

A

after load and inotropy

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7
Q

preload

A

initial stretch prior to contraction, ventricular wall, max stretch = EDV/EDP

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8
Q

starling law

A

more enters, more ejected (heterometric… related to sarcomere length)

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9
Q

what regulation is related to sarcomere length

A

heterometric

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10
Q

starling Mech.

A

myofilament overlap, length dep. activation

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11
Q

compliance is related to

A

preload, less at higher volume…

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12
Q

after load

A

mainly aortic pressure, load against heart ejection

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13
Q

what increases afterload

A

pressure and hypertrophy

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14
Q

isotropy is dependent or intependent?

A

independent!!

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15
Q

what slope is inotropy related to

A

ESVPR

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16
Q

what affects isotropy?

A

sympa/para… affect contraction

17
Q

MOA of inotropy

A

increased Ca++ delivery, increased binding, increase crossbrige activity