cardiac muscle mechanics

Question 1

co=

Answer 1

HR*SV

Question 2

SV=

Answer 2

EDV-ESV

Question 3

ESV

Answer 3

amount remaining in heart after systole

Question 4

EDV

Answer 4

amount filled

Question 5

what affects EDV

Answer 5

preload

Question 6

what affects ESV

Answer 6

after load and inotropy

Question 7

preload

Answer 7

initial stretch prior to contraction, ventricular wall, max stretch = EDV/EDP

Question 8

starling law

Answer 8

more enters, more ejected (heterometric… related to sarcomere length)

Question 9

what regulation is related to sarcomere length

Answer 9

heterometric

Question 10

starling Mech.

Answer 10

myofilament overlap, length dep. activation

Question 11

compliance is related to

Answer 11

preload, less at higher volume…

Question 12

after load

Answer 12

mainly aortic pressure, load against heart ejection

Question 13

what increases afterload

Answer 13

pressure and hypertrophy

Question 14

isotropy is dependent or intependent?

Answer 14

independent!!

Question 15

what slope is inotropy related to

Answer 15

ESVPR

Question 16

what affects isotropy?

Answer 16

sympa/para… affect contraction

Question 17

MOA of inotropy

Answer 17

increased Ca++ delivery, increased binding, increase crossbrige activity