path intro to skin Flashcards
Be familiar with the clinical and histologic terms used to describe skin lesions Know the embryologic and morphologic characteristics of melanocytes Know the clinical and histologic presentation of nevocellular nevi and melanoma Know that other pigmented lesions and variants of melanocytic nevi exist Know the epidemiology of melanoma For melanoma, be familiar with the features that carry prognostic significance
flat, circumscribed lesion < 0.5 cm
macule
flat, circumscribed lesion > 0.5 cm
patch
elevated dome-shaped or flat topped lesion < 0.5 cm
papule
elevated solid area > 0.5 cm
nodule
elevated flat-topped area usually > 0.5 cm
plaque
fluid filled raised area < 0.5 cm
vesicle
fluid filled raised area > .5 cm
bullae
discrete, pus filled area
pustule
transient, pritic, erythematosus lesion often pink with whitish center
wheal
cause of wheals
edema
dry, flaky area on skin
scale
thickened and rough skin with proninent skin markings
lichenifcation
traumatic lesion with epidermal disruption
excoriation
hyperplasia of stratum corneum
hyperkeratosis
kertinization pattern with retentio of nuclei in stratum corneum
parakeratosis
epidermal hyperplasia
acanthosis
abnormal keratinaztion
dyskeratosis
loss of intercellular connections in epidermis
acantholysis
increased intercellularedema in epidermis
spongiosos
incomplete loss of epidermis
erosion
complete loss of epidermis
ulceration
origin of melanocytes
neural crest
patchy loss of melanocytes due to antibodies to them
vitiligo
defect in melanin synthesis
albanism
