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MSK/Skin > path intro to skin > Flashcards

path intro to skin Flashcards

Be familiar with the clinical and histologic terms used to describe skin lesions Know the embryologic and morphologic characteristics of melanocytes Know the clinical and histologic presentation of nevocellular nevi and melanoma Know that other pigmented lesions and variants of melanocytic nevi exist Know the epidemiology of melanoma For melanoma, be familiar with the features that carry prognostic significance

1
Q

flat, circumscribed lesion < 0.5 cm

A

macule

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2
Q

flat, circumscribed lesion > 0.5 cm

A

patch

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3
Q

elevated dome-shaped or flat topped lesion < 0.5 cm

A

papule

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4
Q

elevated solid area > 0.5 cm

A

nodule

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5
Q

elevated flat-topped area usually > 0.5 cm

A

plaque

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6
Q

fluid filled raised area < 0.5 cm

A

vesicle

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7
Q

fluid filled raised area > .5 cm

A

bullae

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8
Q

discrete, pus filled area

A

pustule

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9
Q

transient, pritic, erythematosus lesion often pink with whitish center

A

wheal

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10
Q

cause of wheals

A

edema

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11
Q

dry, flaky area on skin

A

scale

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12
Q

thickened and rough skin with proninent skin markings

A

lichenifcation

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13
Q

traumatic lesion with epidermal disruption

A

excoriation

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14
Q

hyperplasia of stratum corneum

A

hyperkeratosis

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15
Q

kertinization pattern with retentio of nuclei in stratum corneum

A

parakeratosis

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16
Q

epidermal hyperplasia

A

acanthosis

17
Q

abnormal keratinaztion

A

dyskeratosis

18
Q

loss of intercellular connections in epidermis

A

acantholysis

19
Q

increased intercellularedema in epidermis

A

spongiosos

20
Q

incomplete loss of epidermis

A

erosion

21
Q

complete loss of epidermis

A

ulceration

22
Q

origin of melanocytes

A

neural crest

23
Q

patchy loss of melanocytes due to antibodies to them

A

vitiligo

24
Q

defect in melanin synthesis

A

albanism

25
Q

small tan-red or lih brown macle

A

ephelis (freckle)

26
Q

local slight hyperplasia of melanocytes

A

lentigo

27
Q

“mole” term

A

nevocellular nevus

28
Q

composed of melocytes that have lost dendritic processes

A

nevocellularnevus

29
Q

nevus with increased risk of melaoma transformation

A

giant congenital nevus

30
Q

sites of melanoma

A

skin, oral mucose, anogenital mucosa, esophagus, meinges, eye

31
Q

major risk factors for melanoma

A

past hx of melanoma
brief, intermittent, intesne UV exposure between 10-24 years of age
xeroderma pigmentosa

32
Q

familial melanoma gene

A

CDKN2A on 9p21

33
Q

sporadic melanoma gene

A

BRAF, PTEN, p16

34
Q

when to suspect a mole maybe a melanoma

A 
asymmatry
border irregularity
multicolored
diameter > 6 mm
any change
35
Q

metastatic potential of melanoma related to…

A

depth of the tumor

36
Q

most important prognistic indicator of melanoma

A

sentiniel lymph node

MSK/Skin (18 decks)

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