Measles and such Flashcards
Prescribe MMR vaccine for patients. Diagnose measles and mumps. Describe the pathogenesis of congenital rubella. Differentiate variola, vaccinia, and other pox viruses. Diagnose parvovirus infection.
morphology of measles virus
enveloped, negative sense, single stranded RNA virus with 6 structural proteins
location of measles replication
cytoplasm
giant cells indicitve of
measles
transmisson of measles
respiratory droplets
tract of infection of measles
resp tract –> lymphatics –> spleen –> blood stream
measles virus infects what tissues
all epithelial cell surfaces
abrupts onset of illness with cough, coryza, rhinorrhea, photophobia, and conjuctivitis
measles
lesions on buccal mucosa with red halo (koplik’s spots)
measles
koplik spots precede measles rash how long?
12-24 hours
maculopapular lesions
measles
sickest day of measles
day rash appears
causes measles rash
T-cell response to measles virus antigens in endothelial cells of skin capillaries
measles complications
giant cell pneumonia encephalitis SSPE atypical measles secondary bacterial pneumoia
fatal , non rash measles complication in people with defective cell mediated immunity
giant cell pneummonia
CNS issue, myoclonic jerks, photophobia, blindness, coma 6-15 years after measles infection
SSPE
conplication form killed measles virus
atypical measles
where you can grow measles virus
monkey kidneys or human cell cultures
easiest and efficient way to confirm measles
immunoflouracense assay for in cells harvested from mucus, urine, and skin biopsies
giant cells on giemsa stain
measles
treatment for early exposure to measles
pooled immunolobulin or vaccination witin 2/3 days of exposure
acute, painful parotitis
mumps
paramyxoviruses
measles/mumps
out of respiratory sites of mumps
testes, meningies, pancreas and ovaries
where you can row mumps virus
monkey kidneys
multinucleated giant cells
mumps
sites of recovering mumps virus from pts
saliva, urine, pharynx, secrections from Stensen’s duct, and CSF
1/3 of infections are subclinical
mumps
can cause congenital defects in infected pregnant mothers
rubella
togavirus
rubella
envoloped, positive sense, single stranded RNA virus with icosahedral nucleocapsid
rubella
ranges from inapparent infection to lymphedenopathy, mild malaise, corzya, low-grade fever and rash
rubella
irregular pink, maculopapular lesions starting on the face, spreading to the trunk and lasting 3 days
rubella
adult femals with polyarthritis and polyarthalgia
rubella
diagnosis of rubella
specific IgM antibody (in green monkey kidneys)
reinfection can occur in immune folks
rubella
vaccination contraindicated in pregnant women
rubella
time in pregnancy most vunreable to congenital rubella infection
first 20 weeks
baby sx of congenital rubella
cararacts, MR, deafness, heart defects, microcephaly, and rash
“bluberry muffin baby”
congenital rubella
place to detect rubella virus in baby
CSF, urine, rectal swab
serodiagnostic of in utero infection of rubella
IgM in cord serum
time kids born with CRS should be considered infectious
1 year
icosahedral visur with no capsid
B19 parvoviruses
fifth disease virus type
B19 parovirus
pathenogenisis of congenital rubella
affects normal growth, mitosis, and chromosomal structure in cells
distinct non vesicular rash on cheeks, resembing a slap with polyarthritis,
fifth disease
can cause aplastic crisis
fifth disease
fatal parvovirus infection in fetus
hydrops fetalis
virus that spreads to bone marrow
B19 parovirus
dianosis of b19 parvovorus
IgM or viral DNA by PCR
big-ass 2x stranded DNA virus
pox
reolicates it;s genome and assembles virons in cell cytoplams with large cytoplasmic inclusions
pox
difference between pox viruses and chickenpox
all skin lesions are the same stage in development in pox diseases
variola causes
smallpox
vaccina casues
cowpox
replication site of pox
upper resp tract
western/central africa pox virus
monkey pox
sheep pox that can be transmitted to humans
orf virus
clusters of wart lije viruses on the face
molluscum contagiosum
diagnostic for molluscum contagiosum
large cytoplasmic inclusions