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MSK/Skin > Measles and such > Flashcards

Measles and such Flashcards

Prescribe MMR vaccine for patients. Diagnose measles and mumps. Describe the pathogenesis of congenital rubella. Differentiate variola, vaccinia, and other pox viruses. Diagnose parvovirus infection.

1
Q

morphology of measles virus

A

enveloped, negative sense, single stranded RNA virus with 6 structural proteins

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2
Q

location of measles replication

A

cytoplasm

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3
Q

giant cells indicitve of

A

measles

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4
Q

transmisson of measles

A

respiratory droplets

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5
Q

tract of infection of measles

A

resp tract –> lymphatics –> spleen –> blood stream

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6
Q

measles virus infects what tissues

A

all epithelial cell surfaces

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7
Q

abrupts onset of illness with cough, coryza, rhinorrhea, photophobia, and conjuctivitis

A

measles

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8
Q

lesions on buccal mucosa with red halo (koplik’s spots)

A

measles

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9
Q

koplik spots precede measles rash how long?

A

12-24 hours

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10
Q

maculopapular lesions

A

measles

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11
Q

sickest day of measles

A

day rash appears

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12
Q

causes measles rash

A

T-cell response to measles virus antigens in endothelial cells of skin capillaries

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13
Q

measles complications

A 
giant cell pneumonia
encephalitis
SSPE
atypical measles
secondary bacterial pneumoia
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14
Q

fatal , non rash measles complication in people with defective cell mediated immunity

A

giant cell pneummonia

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15
Q

CNS issue, myoclonic jerks, photophobia, blindness, coma 6-15 years after measles infection

A

SSPE

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16
Q

conplication form killed measles virus

A

atypical measles

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17
Q

where you can grow measles virus

A

monkey kidneys or human cell cultures

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18
Q

easiest and efficient way to confirm measles

A

immunoflouracense assay for in cells harvested from mucus, urine, and skin biopsies

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19
Q

giant cells on giemsa stain

A

measles

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20
Q

treatment for early exposure to measles

A

pooled immunolobulin or vaccination witin 2/3 days of exposure

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21
Q

acute, painful parotitis

A

mumps

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22
Q

paramyxoviruses

A

measles/mumps

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23
Q

out of respiratory sites of mumps

A

testes, meningies, pancreas and ovaries

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24
Q

where you can row mumps virus

A

monkey kidneys

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25
Q

multinucleated giant cells

A

mumps

26
Q

sites of recovering mumps virus from pts

A

saliva, urine, pharynx, secrections from Stensen’s duct, and CSF

27
Q

1/3 of infections are subclinical

A

mumps

28
Q

can cause congenital defects in infected pregnant mothers

A

rubella

29
Q

togavirus

A

rubella

30
Q

envoloped, positive sense, single stranded RNA virus with icosahedral nucleocapsid

A

rubella

31
Q

ranges from inapparent infection to lymphedenopathy, mild malaise, corzya, low-grade fever and rash

A

rubella

32
Q

irregular pink, maculopapular lesions starting on the face, spreading to the trunk and lasting 3 days

A

rubella

33
Q

adult femals with polyarthritis and polyarthalgia

A

rubella

34
Q

diagnosis of rubella

A

specific IgM antibody (in green monkey kidneys)

35
Q

reinfection can occur in immune folks

A

rubella

36
Q

vaccination contraindicated in pregnant women

A

rubella

37
Q

time in pregnancy most vunreable to congenital rubella infection

A

first 20 weeks

38
Q

baby sx of congenital rubella

A

cararacts, MR, deafness, heart defects, microcephaly, and rash

39
Q

“bluberry muffin baby”

A

congenital rubella

40
Q

place to detect rubella virus in baby

A

CSF, urine, rectal swab

41
Q

serodiagnostic of in utero infection of rubella

A

IgM in cord serum

42
Q

time kids born with CRS should be considered infectious

A

1 year

43
Q

icosahedral visur with no capsid

A

B19 parvoviruses

44
Q

fifth disease virus type

A

B19 parovirus

45
Q

pathenogenisis of congenital rubella

A

affects normal growth, mitosis, and chromosomal structure in cells

46
Q

distinct non vesicular rash on cheeks, resembing a slap with polyarthritis,

A

fifth disease

47
Q

can cause aplastic crisis

A

fifth disease

48
Q

fatal parvovirus infection in fetus

A

hydrops fetalis

49
Q

virus that spreads to bone marrow

A

B19 parovirus

50
Q

dianosis of b19 parvovorus

A

IgM or viral DNA by PCR

51
Q

big-ass 2x stranded DNA virus

A

pox

52
Q

reolicates it;s genome and assembles virons in cell cytoplams with large cytoplasmic inclusions

A

pox

53
Q

difference between pox viruses and chickenpox

A

all skin lesions are the same stage in development in pox diseases

54
Q

variola causes

A

smallpox

55
Q

vaccina casues

A

cowpox

56
Q

replication site of pox

A

upper resp tract

57
Q

western/central africa pox virus

A

monkey pox

58
Q

sheep pox that can be transmitted to humans

A

orf virus

59
Q

clusters of wart lije viruses on the face

A

molluscum contagiosum

60
Q

diagnostic for molluscum contagiosum

A

large cytoplasmic inclusions

MSK/Skin (18 decks)

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