cutaneous neoplasms

Question 1

mutation in seborrheic keratosis

Answer 1

FGF3

Question 2

multiple sudden lesions that can possibly be paraneoplastic

Answer 2

seborrheic keratosis

Question 3

round, exophytic, coinlike “stuck-on” lesions

Answer 3

seborrheic keratosis

Question 4

monotonous sheets of small cells that resemble the basal cells of normal epidermis with variable pigment

Answer 4

seborrheic keratosis

Question 5

less than 1 cm, tan-brown or red in color rough to the touch

Answer 5

actinic keratoses

Question 6

cytologic atypia with hyperplasia of basal cells or atrophy and diffuse thinning of the epidermal surface.

Answer 6

actinic keratoses

Question 7

lesions considered squamous cell carcinoma in situ

Answer 7

actinic keratosis with full thickness epiderimal atypia

Question 8

dermis contains thickened blue-gray elastic fibers

Answer 8

actinic keratosis

Question 9

present on sun-exposed skin

Answer 9

actinic keratosis

Question 10

common tumor arising on sun-exposed surfaces in older people

Answer 10

sqaumous cell carcinoma

Question 11

most common cause of sqaumous cell carcinoma

Answer 11

UV damage

Question 12

mutation involved in sqaumous cell carcinoma

Answer 12

TP53 caused by UV, HRAS

Question 13

sharpley defined, red scaling plaques advancing to nodular and ulcerative lesions

Answer 13

sqaumous cell carcinoma

Question 14

highly atypical cells at all levels of the epidermis

Answer 14

sqaumous cell carcinoma

Question 15

likelyhood of metastasis of sqaumous cell carcinoma tied to

Answer 15

thickness of lesion and degree of invasion into subQ tissue

Question 16

associated with dysregulatio of hedgehog pathway

Answer 16

basal cell carcinoma

Question 17

mutation in Basal cell carcinoma

Answer 17

PTCH

Question 18

pearly papules often with priminent telangiectasia

Answer 18

basal cell carcinoma

Question 19

two types of basal cell carcinoma

Answer 19

multifocal growth or nodular lesions

Question 20

nest of basaloid cells infiltrating fibrotic stroma

Answer 20

BCC

Question 21

% of BCC pts who develop another tumor in 5 years

Answer 21

40%

Question 22

skin cancer with very rare metastasis

Answer 22

BCC

Question 23

hyperkeratosis and horn pseudocysts

Answer 23

seborrheic keratosis

Question 24

spontaneous resolution without treatment

Answer 24

seborrheic keratosis

Question 25

"volcano" looking lesion

Answer 25

keratoacanthoma

Question 26

xeroderma pigmentosa a risk for

Answer 26

squamous cell carcinoma

Question 27

peripheral pallisading

Answer 27

basal cell carcinoma

Question 28

firm, tan to brown papule in the legs of a young-middle aged person

Answer 28

dermatofibroma

Question 29

lesion that is factor XIIIa+

Answer 29

dermatofibroma

Question 30

composed of fibroblass, histiocytes and dendrocytes

Answer 30

dermatofibroma

Question 31

large, furm lumpy nodule on trunk or proximal extremities in young to middle aged adult

Answer 31

dermatofibrosarcoma protunerans

Question 32

proliferation of monomorpheois spindle cells wih honeycomb pattern of fat entrapment

Answer 32

dermatofibrosarcoma protunerans

Question 33

pink to skin colored papules , pustles and vesicles in kids

Answer 33

langerhans cell histiocytosis

Question 34

can have osetolytic lesions

Answer 34

langerhans cell histiocytosis

Question 35

bean shaped nuclei wih irreular contours

Answer 35

langerhans cell histiocytosis

Question 36

expresses CD34

Answer 36

dermatofibrosarcoma protunerans

Question 37

express s-100+ and CD1a+

Answer 37

langerhans cell histiocytosis

Question 38

tennis raquet shaped birbeck granule

Answer 38

langerhans cell histiocytosis

Question 39

poor prognosis mastocytois

Answer 39

systemic

Question 40

mastocytosis usually seen in kids

Answer 40

urticaria pigmentosa

Question 41

round to oval, red/brown, non scaling papules and plaques

Answer 41

mastocytosis

Question 42

rubbing causes erythema and edema

Answer 42

mastocytosis

Question 43

expresses CD117

Answer 43

mastocytosis