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MSK/Skin > cutaneous neoplasms > Flashcards

cutaneous neoplasms Flashcards

Know the clinical and histologic features of seborrheic keratosis Know the clinical and histologic features of actinic keratosis Know the clinical and histologic features of squamous cell carcinoma Know the clinical and histologic features of basal cell carcinoma Know the clinical and histologic features of dermatofibroma Know the clinical and histologic features of dermatofibrosarcoma protuberans Know the clinical and histologic features of langerhans cell histiocytosis Know the clinical

1
Q

mutation in seborrheic keratosis

A

FGF3

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2
Q

multiple sudden lesions that can possibly be paraneoplastic

A

seborrheic keratosis

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3
Q

round, exophytic, coinlike “stuck-on” lesions

A

seborrheic keratosis

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4
Q

monotonous sheets of small cells that resemble the basal cells of normal epidermis with variable pigment

A

seborrheic keratosis

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5
Q

less than 1 cm, tan-brown or red in color rough to the touch

A

actinic keratoses

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6
Q

cytologic atypia with hyperplasia of basal cells or atrophy and diffuse thinning of the epidermal surface.

A

actinic keratoses

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7
Q

lesions considered squamous cell carcinoma in situ

A

actinic keratosis with full thickness epiderimal atypia

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8
Q

dermis contains thickened blue-gray elastic fibers

A

actinic keratosis

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9
Q

present on sun-exposed skin

A

actinic keratosis

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10
Q

common tumor arising on sun-exposed surfaces in older people

A

sqaumous cell carcinoma

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11
Q

most common cause of sqaumous cell carcinoma

A

UV damage

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12
Q

mutation involved in sqaumous cell carcinoma

A

TP53 caused by UV, HRAS

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13
Q

sharpley defined, red scaling plaques advancing to nodular and ulcerative lesions

A

sqaumous cell carcinoma

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14
Q

highly atypical cells at all levels of the epidermis

A

sqaumous cell carcinoma

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15
Q

likelyhood of metastasis of sqaumous cell carcinoma tied to

A

thickness of lesion and degree of invasion into subQ tissue

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16
Q

associated with dysregulatio of hedgehog pathway

A

basal cell carcinoma

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17
Q

mutation in Basal cell carcinoma

A

PTCH

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18
Q

pearly papules often with priminent telangiectasia

A

basal cell carcinoma

19
Q

two types of basal cell carcinoma

A

multifocal growth or nodular lesions

20
Q

nest of basaloid cells infiltrating fibrotic stroma

A

BCC

21
Q

% of BCC pts who develop another tumor in 5 years

A

40%

22
Q

skin cancer with very rare metastasis

A

BCC

23
Q

hyperkeratosis and horn pseudocysts

A

seborrheic keratosis

24
Q

spontaneous resolution without treatment

A

seborrheic keratosis

25
Q

“volcano” looking lesion

A

keratoacanthoma

26
Q

xeroderma pigmentosa a risk for

A

squamous cell carcinoma

27
Q

peripheral pallisading

A

basal cell carcinoma

28
Q

firm, tan to brown papule in the legs of a young-middle aged person

A

dermatofibroma

29
Q

lesion that is factor XIIIa+

A

dermatofibroma

30
Q

composed of fibroblass, histiocytes and dendrocytes

A

dermatofibroma

31
Q

large, furm lumpy nodule on trunk or proximal extremities in young to middle aged adult

A

dermatofibrosarcoma protunerans

32
Q

proliferation of monomorpheois spindle cells wih honeycomb pattern of fat entrapment

A

dermatofibrosarcoma protunerans

33
Q

pink to skin colored papules , pustles and vesicles in kids

A

langerhans cell histiocytosis

34
Q

can have osetolytic lesions

A

langerhans cell histiocytosis

35
Q

bean shaped nuclei wih irreular contours

A

langerhans cell histiocytosis

36
Q

expresses CD34

A

dermatofibrosarcoma protunerans

37
Q

express s-100+ and CD1a+

A

langerhans cell histiocytosis

38
Q

tennis raquet shaped birbeck granule

A

langerhans cell histiocytosis

39
Q

poor prognosis mastocytois

A

systemic

40
Q

mastocytosis usually seen in kids

A

urticaria pigmentosa

41
Q

round to oval, red/brown, non scaling papules and plaques

A

mastocytosis

42
Q

rubbing causes erythema and edema

A

mastocytosis

43
Q

expresses CD117

A

mastocytosis

MSK/Skin (18 decks)

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