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MSK/Skin > inflammatory dermopathies > Flashcards

inflammatory dermopathies Flashcards

Be familiar with the clinical and histologic features of the acute inflammatory dermatoses:Urticaria, eczema/atopic dermatitis and erythema multiforme Be familiar with the clinical and histologic features of the acute inflammatory dermatoses:psoriasis, lichen planus and lupus erythematosus Be familiar with the clinical and histologic features of the autoimmune dermopathies: pemphigus vulgaris, bullous pemphigoid, dermatitis herpetiformis, and epidermolysis bullosa aquisita

1
Q

hereditary angioedema caused by

A

inherited deficency of C1 esterase inhibitor

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2
Q

localized mast cell degranulation leads to…

A

dermal microvascular hyperpermeability (urticaria)

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3
Q

red papules, with overlapping vesicles that ooze and become encrusted

A

acute excematous dermatitis (eczema)

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4
Q

epidermal edema also known as

A

spongiosis

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5
Q

immune presenting cells in skin

A

langerhans cells

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6
Q

condition where fluid seeps into the epidermis, splaying apaty keratinocytes

A

spongiotic dermatitis

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7
Q

hypersensitivity reaction to certain infections and drugs

A

erythema multiforme

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8
Q

infections that can cause erythema multiforme

A

herpes simplex, some mycoplasms and fungi

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9
Q

drugs that can cause erythema multiforme

A

sulfaonamides, penicillin, salicytes, hydantoins, antimalarials

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10
Q

wide diversity of lesions including macules, papules, vesicles and bullae with target lookin lesions

A

erythema multiforme

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11
Q

erythema multiforme pathenogenisis

A

skin-homing cytotoxic T cells attackin basal cells of the skin and mucosa

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12
Q

superfical perivascular lymphocytic infiltrate with epidermal edema abd degenerating keratinocytes

A

erythema multiforme

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13
Q

severe form of erythema multiforme

A

toxic epidermal necrolysis

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14
Q

complications of psorisis

A

heart attacks and stokes, arthritis

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15
Q

koebner phenomenon

A

psoroatic lesions brought on by trauma

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16
Q

cells mediating psorias reactions

A

T cells inducing keratinocyte hyperproliferation

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17
Q

well-demarcated pink to salmon colored plaque covered by looseky adherend silver-white scale

A

psorisis

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18
Q

rete ridges “test tubes in a rack”

A

psorisis

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19
Q

auspitz sign

A

multiple bleeding sites in psorisis

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20
Q

casues scaleing in psorisis

A

loss of stratum granulosum and extensive parakeratotic scale

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21
Q

treatment of psorisis

A

NSAIDS, cyclosporin, TNF antagonosts

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22
Q

puritic, ciolaceousm flat topped papules highlighted with white dots or lines

A

lichen planus

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23
Q

lesions concentrated at interface of sqaumous epithelium and papillary sermis

A

interface dermatitis

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24
Q

microscopic “sawtoothing” abd civatte bodies

A

lichen planus

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25
Q

symmettic lesions on wrists, elbows, glans penis and often in the mouth

A

lichen planus

26
Q

acanthosis, hyperkeratosis and hypergranulosis

A

lichen simplex chronicus

27
Q

lesions that look like normal palm/dorsum of foot thckening

A

lichen simplex chronicus

28
Q

protiens attacked in pemphigus diseases

A

demmoglein

29
Q

type of hypersensitivity reaction in pemphius diseases

A

II

30
Q

immunoglobulin attacking in pemphigus diseases

A

IgG

31
Q

“fishnet pattern” on immunoflourecence

A

pemphigus vulgaris

32
Q

superficial flaccid vesicles and bullae that rupture easily leaving extensive erosions and crust

A

pemphigus vulgaris

33
Q

pemphigus disease that attacks mucosa and skin

A

pemphigus vulgaris

34
Q

lysis of the intercellular adhesive junctions between neihboring squamous epithelial cells

A

acantholysis

35
Q

detachment involves the cells immediatly ABOVE the basal layer

A

pemphigus vulgaris

36
Q

pemphigus disease that mostly strikes elderly women and has oropharnygeal involvement

A

pemphigus vulgaris

37
Q

site of attack in bullous pemphigus

A

hemidesmosomes

38
Q

linear immunoflourecense in subepidermal basement membrane zone

A

bullous pemphigus

39
Q

tense, fluid-filled blisters

A

bullous pemphigus

40
Q

subepidermal nonacantholytic blisters

A

bullous pemphigus

41
Q

full thickness epidermal blisters

A

bullous pemphigus

42
Q

blisters do not rupture as easily

A

bullous pemphigus

43
Q

extremly prurtic urticaria and grouped vesicles

A

dermatitis herpetiformis

44
Q

strong association with celiac disease

A

dermatitis herpetiformis

45
Q

granular deposits of IgA at tips of dermal papillae

A

dermatitis herpetiformis

46
Q

Stevens-Johnson syndrome

A

severe form of erythema multiforme

47
Q

causes Stevens-Johnson syndrome

A

sulfanomnides

48
Q

severe form of Stevens Johnson syndrome

A

toxic epidermal necolysis

49
Q

nikolsky sign

A

rubbing of skin produces blister (toxic epidermal necolysis)

50
Q

pitting of fingernails

A

psoriasis

51
Q

psoriasis associated with

A

arthritis, mypopathy, enteropathy, AIDS, CV disease, depression

52
Q

malar erythema, worse in sun exposed skin,

A

lupus erythematosus

53
Q

superficial and deep perivascular lyphocytic infiltrate with inflammation around hair follicles and sweat glands

A

lupus erythematosus

54
Q

IgG against desmosomes

A

pemphius vulgaris

55
Q

antibodies to gluten

A

demratiis herpetiformis

56
Q

non0inflammatory acral blisters that heal with scar

A

epidermolysis bullosa aquisista

57
Q

antibodies to collagen VII

A

epidermolysis bullosa aquisista

58
Q

paucicellular subepidermal blister

A

epidermolysis bullosa aquisista

59
Q

immunoflorecent line between epidermis and dermis

A

epidermolysis bullosa aquisista

60
Q

collagen vascular diseases associated with

A

erythema multoforma

MSK/Skin (18 decks)

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