inflammatory dermopathies

Question 1

hereditary angioedema caused by

Answer 1

inherited deficency of C1 esterase inhibitor

Question 2

localized mast cell degranulation leads to…

Answer 2

dermal microvascular hyperpermeability (urticaria)

Question 3

red papules, with overlapping vesicles that ooze and become encrusted

Answer 3

acute excematous dermatitis (eczema)

Question 4

epidermal edema also known as

Answer 4

spongiosis

Question 5

immune presenting cells in skin

Answer 5

langerhans cells

Question 6

condition where fluid seeps into the epidermis, splaying apaty keratinocytes

Answer 6

spongiotic dermatitis

Question 7

hypersensitivity reaction to certain infections and drugs

Answer 7

erythema multiforme

Question 8

infections that can cause erythema multiforme

Answer 8

herpes simplex, some mycoplasms and fungi

Question 9

drugs that can cause erythema multiforme

Answer 9

sulfaonamides, penicillin, salicytes, hydantoins, antimalarials

Question 10

wide diversity of lesions including macules, papules, vesicles and bullae with target lookin lesions

Answer 10

erythema multiforme

Question 11

erythema multiforme pathenogenisis

Answer 11

skin-homing cytotoxic T cells attackin basal cells of the skin and mucosa

Question 12

superfical perivascular lymphocytic infiltrate with epidermal edema abd degenerating keratinocytes

Answer 12

erythema multiforme

Question 13

severe form of erythema multiforme

Answer 13

toxic epidermal necrolysis

Question 14

complications of psorisis

Answer 14

heart attacks and stokes, arthritis

Question 15

koebner phenomenon

Answer 15

psoroatic lesions brought on by trauma

Question 16

cells mediating psorias reactions

Answer 16

T cells inducing keratinocyte hyperproliferation

Question 17

well-demarcated pink to salmon colored plaque covered by looseky adherend silver-white scale

Answer 17

psorisis

Question 18

rete ridges “test tubes in a rack”

Answer 18

psorisis

Question 19

auspitz sign

Answer 19

multiple bleeding sites in psorisis

Question 20

casues scaleing in psorisis

Answer 20

loss of stratum granulosum and extensive parakeratotic scale

Question 21

treatment of psorisis

Answer 21

NSAIDS, cyclosporin, TNF antagonosts

Question 22

puritic, ciolaceousm flat topped papules highlighted with white dots or lines

Answer 22

lichen planus

Question 23

lesions concentrated at interface of sqaumous epithelium and papillary sermis

Answer 23

interface dermatitis

Question 24

microscopic “sawtoothing” abd civatte bodies

Answer 24

lichen planus

Question 25

symmettic lesions on wrists, elbows, glans penis and often in the mouth

Answer 25

lichen planus

Question 26

acanthosis, hyperkeratosis and hypergranulosis

Answer 26

lichen simplex chronicus

Question 27

lesions that look like normal palm/dorsum of foot thckening

Answer 27

lichen simplex chronicus

Question 28

protiens attacked in pemphigus diseases

Answer 28

demmoglein

Question 29

type of hypersensitivity reaction in pemphius diseases

Answer 29

II

Question 30

immunoglobulin attacking in pemphigus diseases

Answer 30

IgG

Question 31

"fishnet pattern" on immunoflourecence

Answer 31

pemphigus vulgaris

Question 32

superficial flaccid vesicles and bullae that rupture easily leaving extensive erosions and crust

Answer 32

pemphigus vulgaris

Question 33

pemphigus disease that attacks mucosa and skin

Answer 33

pemphigus vulgaris

Question 34

lysis of the intercellular adhesive junctions between neihboring squamous epithelial cells

Answer 34

acantholysis

Question 35

detachment involves the cells immediatly ABOVE the basal layer

Answer 35

pemphigus vulgaris

Question 36

pemphigus disease that mostly strikes elderly women and has oropharnygeal involvement

Answer 36

pemphigus vulgaris

Question 37

site of attack in bullous pemphigus

Answer 37

hemidesmosomes

Question 38

linear immunoflourecense in subepidermal basement membrane zone

Answer 38

bullous pemphigus

Question 39

tense, fluid-filled blisters

Answer 39

bullous pemphigus

Question 40

subepidermal nonacantholytic blisters

Answer 40

bullous pemphigus

Question 41

full thickness epidermal blisters

Answer 41

bullous pemphigus

Question 42

blisters do not rupture as easily

Answer 42

bullous pemphigus

Question 43

extremly prurtic urticaria and grouped vesicles

Answer 43

dermatitis herpetiformis

Question 44

strong association with celiac disease

Answer 44

dermatitis herpetiformis

Question 45

granular deposits of IgA at tips of dermal papillae

Answer 45

dermatitis herpetiformis

Question 46

Stevens-Johnson syndrome

Answer 46

severe form of erythema multiforme

Question 47

causes Stevens-Johnson syndrome

Answer 47

sulfanomnides

Question 48

severe form of Stevens Johnson syndrome

Answer 48

toxic epidermal necolysis

Question 49

nikolsky sign

Answer 49

rubbing of skin produces blister (toxic epidermal necolysis)

Question 50

pitting of fingernails

Answer 50

psoriasis

Question 51

psoriasis associated with

Answer 51

arthritis, mypopathy, enteropathy, AIDS, CV disease, depression

Question 52

malar erythema, worse in sun exposed skin,

Answer 52

lupus erythematosus

Question 53

superficial and deep perivascular lyphocytic infiltrate with inflammation around hair follicles and sweat glands

Answer 53

lupus erythematosus

Question 54

IgG against desmosomes

Answer 54

pemphius vulgaris

Question 55

antibodies to gluten

Answer 55

demratiis herpetiformis

Question 56

non0inflammatory acral blisters that heal with scar

Answer 56

epidermolysis bullosa aquisista

Question 57

antibodies to collagen VII

Answer 57

epidermolysis bullosa aquisista

Question 58

paucicellular subepidermal blister

Answer 58

epidermolysis bullosa aquisista

Question 59

immunoflorecent line between epidermis and dermis

Answer 59

epidermolysis bullosa aquisista

Question 60

collagen vascular diseases associated with

Answer 60

erythema multoforma