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MSK/Skin > Bacterial Infection 1 > Flashcards

Bacterial Infection 1 Flashcards

Compare and contrast the immune parameters of tuberculoid leprosy and lepromatous leprosy. Diagnose an infection with Nocardia. Identify the epidemiology and pathogenesis of plague, anthrax, and tularemia.

1
Q

morphology of bacililus

A

gram + spore formiong bacilli

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2
Q

types of anthrax infection

A

cutaneous, GI, pulmonary

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3
Q

industry associated with most anthrax infections

A

textile

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4
Q

animals most often infected with anthrax

A

sheep, then cattle

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5
Q

most common type of human anthrax infection

A

cutaneous

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6
Q

decribe anthrax skin presentation

A

painless pruritic papule that vesiculates and ulcerates with draining of a blackish exudate

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7
Q

GI presentation of anthrax

A

n/v, and fever progrssing to hemorragic vomiting abdominal pain and shock

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8
Q

mortality of GI anthrax

A

50%

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9
Q

mortality of skin anthrax

A

20% untreated

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10
Q

mortality of inhaled anthrax

A

> 80%

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11
Q

name the plasmid encoding anthrax toxins

A

pXO1

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12
Q

3 anthrax toxins

A

protective antigen, edema factor, and lethal factor

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13
Q

A-B anthrax toxins

A

edema and lethal

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14
Q

forms the lethal toxin

A

protctive antigen and lethal factor

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15
Q

forms the edema toxin

A

protective antigen and edema factor

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16
Q

anthrax factor that is an adenylate cyclase

A

edema factor

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17
Q

activates edema factor

A

intracellular calmodulin and Ca++

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18
Q

MOA of lethal factorq

A

cleaves MAPKK inside macrophages. inhibits signal transduction leading to cell death

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19
Q

makeup of anthrax protien capsule

A

poly-D glutamic acid

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20
Q

plasmid encoding anthrax capsule

A

pXO2

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21
Q

regulates transcription of anthrax toxin and capsule

A

body temp and CO2

22
Q

DOC for anthrasx

A

penicillin/Cipro.doxy

23
Q

prevention of anthrax

A

vaccination of livestock, burying of unbroken cattle carcasses

24
Q

genus of plauge

A

yersinia

25
Q

morphology of yersinia

A

gram - rods, looking like safety pins

26
Q

virulence factors for yersiniae

A

adhesin, Yop proteins, low calcium rtesponse V antigen, hemin storage factor

27
Q

proteins injected into the host cell by yersiniae

A

Yop

28
Q

MOA of Yop proteins

A

interfere with phagocytosis, detroying filaments and inhibiting platelet aggregation of eukaryotic cells

29
Q

promotes Y pestis colonization in flea proventriculus

A

Hms

30
Q

y pestis virulence factor that suppresses host immune response

A

LcrV

31
Q

pandemic plague

A

urban

32
Q

sporadic plague

A

sylvatic

33
Q

resivoir for yersini pestis

A

rat

34
Q

vector for plague

A

rat flea

35
Q

way fleas transnit plague

A

vomiting infected blood from infected host into wound of new host

36
Q

highest mortality plague

A

pnemonic

37
Q

clinical types of plague

A

pnemonic and bubonic

38
Q

culture mediums of plague

A

blood/maconcky agar

39
Q

DOC for plague

A

streptomyocin

40
Q

morpholoy of f tularensis

A

very small gm - coccobacillus

41
Q

virulance factor in tularensis

A

capsule and endotoxin

42
Q

resivoir of tuleramia

A

rabbits and small mammals

43
Q

vector of tuleremia

A

ticks and deer flies

44
Q

main range of tuleramia

A

arkansas/missouri

45
Q

most virulent type of tuleramia

A

type A

46
Q

number of tulerima bacteria that can make you sick if inhaled

A

10

47
Q

pathogenesis of tulermia

A

infects organs rish with fixed tossue macrophages causing granulomas and necrosis

48
Q

way tulermia survives macrophages

A

inhibits phagsome lysosome function

49
Q

most common form of tuleramia

A

ulceroglandular

50
Q

sx of ulceroglandular tulermia

A

local papule forms at site of inculation and becomes painful and ulcerative. Mat involve regional lymph nodes

51
Q

media crowing tuleremia

A

cystein supplemented chocolate agar

52
Q

DOC of tuleremia

A

streptomycin. possible gentamicin, fluroquinolones, and doxy

MSK/Skin (18 decks)

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