Bacterial Infection 1

Question 1

morphology of bacililus

Answer 1

gram + spore formiong bacilli

Question 2

types of anthrax infection

Answer 2

cutaneous, GI, pulmonary

Question 3

industry associated with most anthrax infections

Answer 3

textile

Question 4

animals most often infected with anthrax

Answer 4

sheep, then cattle

Question 5

most common type of human anthrax infection

Answer 5

cutaneous

Question 6

decribe anthrax skin presentation

Answer 6

painless pruritic papule that vesiculates and ulcerates with draining of a blackish exudate

Question 7

GI presentation of anthrax

Answer 7

n/v, and fever progrssing to hemorragic vomiting abdominal pain and shock

Question 8

mortality of GI anthrax

Answer 8

50%

Question 9

mortality of skin anthrax

Answer 9

20% untreated

Question 10

mortality of inhaled anthrax

Answer 10

> 80%

Question 11

name the plasmid encoding anthrax toxins

Answer 11

pXO1

Question 12

3 anthrax toxins

Answer 12

protective antigen, edema factor, and lethal factor

Question 13

A-B anthrax toxins

Answer 13

edema and lethal

Question 14

forms the lethal toxin

Answer 14

protctive antigen and lethal factor

Question 15

forms the edema toxin

Answer 15

protective antigen and edema factor

Question 16

anthrax factor that is an adenylate cyclase

Answer 16

edema factor

Question 17

activates edema factor

Answer 17

intracellular calmodulin and Ca++

Question 18

MOA of lethal factorq

Answer 18

cleaves MAPKK inside macrophages. inhibits signal transduction leading to cell death

Question 19

makeup of anthrax protien capsule

Answer 19

poly-D glutamic acid

Question 20

plasmid encoding anthrax capsule

Answer 20

pXO2

Question 21

regulates transcription of anthrax toxin and capsule

Answer 21

body temp and CO2

Question 22

DOC for anthrasx

Answer 22

penicillin/Cipro.doxy

Question 23

prevention of anthrax

Answer 23

vaccination of livestock, burying of unbroken cattle carcasses

Question 24

genus of plauge

Answer 24

yersinia

Question 25

morphology of yersinia

Answer 25

gram - rods, looking like safety pins

Question 26

virulence factors for yersiniae

Answer 26

adhesin, Yop proteins, low calcium rtesponse V antigen, hemin storage factor

Question 27

proteins injected into the host cell by yersiniae

Answer 27

Yop

Question 28

MOA of Yop proteins

Answer 28

interfere with phagocytosis, detroying filaments and inhibiting platelet aggregation of eukaryotic cells

Question 29

promotes Y pestis colonization in flea proventriculus

Answer 29

Hms

Question 30

y pestis virulence factor that suppresses host immune response

Answer 30

LcrV

Question 31

pandemic plague

Answer 31

urban

Question 32

sporadic plague

Answer 32

sylvatic

Question 33

resivoir for yersini pestis

Answer 33

rat

Question 34

vector for plague

Answer 34

rat flea

Question 35

way fleas transnit plague

Answer 35

vomiting infected blood from infected host into wound of new host

Question 36

highest mortality plague

Answer 36

pnemonic

Question 37

clinical types of plague

Answer 37

pnemonic and bubonic

Question 38

culture mediums of plague

Answer 38

blood/maconcky agar

Question 39

DOC for plague

Answer 39

streptomyocin

Question 40

morpholoy of f tularensis

Answer 40

very small gm - coccobacillus

Question 41

virulance factor in tularensis

Answer 41

capsule and endotoxin

Question 42

resivoir of tuleramia

Answer 42

rabbits and small mammals

Question 43

vector of tuleremia

Answer 43

ticks and deer flies

Question 44

main range of tuleramia

Answer 44

arkansas/missouri

Question 45

most virulent type of tuleramia

Answer 45

type A

Question 46

number of tulerima bacteria that can make you sick if inhaled

Answer 46

10

Question 47

pathogenesis of tulermia

Answer 47

infects organs rish with fixed tossue macrophages causing granulomas and necrosis

Question 48

way tulermia survives macrophages

Answer 48

inhibits phagsome lysosome function

Question 49

most common form of tuleramia

Answer 49

ulceroglandular

Question 50

sx of ulceroglandular tulermia

Answer 50

local papule forms at site of inculation and becomes painful and ulcerative. Mat involve regional lymph nodes

Question 51

media crowing tuleremia

Answer 51

cystein supplemented chocolate agar

Question 52

DOC of tuleremia

Answer 52

streptomycin. possible gentamicin, fluroquinolones, and doxy