Path Bleeding disorders

Question 1

overproduction of corticosteroids from adrenal

cortex

Answer 1

Cushing’s Syndrome brittle blood vessels, severe osteoporosis, obesity, diabetes,high BP

Question 2

o Prolonged steroid medication use can have symptoms similar to

Answer 2

Cushing’s, easy bruising

Question 3

bruises > 2 cm

Answer 3

Ecchymoses

Question 4

– larger than a pinpoint, but < 2 cm

Answer 4

Purpura

Question 5

– leak of blood into cavities o

Answer 5

Hematoma

Question 6

Rupture of middle meningeal artery

Answer 6

epidural hematoma

Question 7

Thrombocytopenia

Answer 7

Normal amount of platelets in blood: 250,000 – 300,000

< 140,000 = prone to hemorrhage

Petechial or purpural rashes are typical—needs to be less than 2 cm

Question 8

no platelet activation  cannot form platelet plug

hemorrhagic gastroduodenitis— balck stool

Answer 8

 Von Willebrand’s Disease

Question 9

– increased amount of blood lost during menstruation

Answer 9

menorrhagia (related to von willebrand’s)

Question 10

serious
disorder manifested usually from uterus cancer, which results in
loss of blood between menstruation periods

Answer 10

metrorrhagia/not related to Von W

Question 11

non-production of certain protein clotting factors

Answer 11

Hemophilia

Question 12

Hemophilia genetics

Answer 12

mother to son X chromosome (skips a generation)

Question 13

nonproduction of CF 8 viii

Answer 13

Hemophilia A

Question 14

nonproduction of CF 9

Answer 14

Christmas disease/Hemophilia B

Question 15

Hemoarthritis

Answer 15

Trauma leads to blood in joint spaces, esp. Knee joint

Iron released from heme into blood destroys the joint cartilage

Question 16

Hemodynamic Disorders

Answer 16

 Disorders that arise from interruptions in normal blood flow

Question 17

platelet activation and platelet aggregation

without threat of blood loss or vascular damage; platelet plug without blood clot

Answer 17

Thrombosis

Question 18

always originates from a vascular wall and always maintains point of contact with the vascular wall through von Willebrand factorplatelet
activaton and platelet aggregation

Answer 18

Thrombus

Question 19

Thrombus in the arterial system

Answer 19

Dense and strong , firm and small (fast)

Question 20

Thrombus in the venous system

Answer 20

Loose and weak , loose and large (slow)

Question 21

represent a special type of thrombi characterized by visible and
microscopic laminations produced by alternating layers: pale layer composed of
platelets mixed with fibrin and dark layer composed of RBCs

Answer 21

Lines of Zahn

Question 22

lines of Zahn + thrombi can be found

Answer 22

heart/aorta(mitral stenosis)

Question 23

factors predisposing to thrombosis

Answer 23

Endothelial damage
Hypertension- increase resistance of the vascular wall to the fluid. Serious factor
that promotes endothelial damage.

Question 24

Iatrogenic thrombosis

Answer 24

medically induces endothelial damage via syringes.

Question 25

Decreased rate of flow causes a disruption in axial blood flow by

Answer 25

platelets flow closer to the vessel wall

Question 26

decreased rate of blood flow caused by

Answer 26

cardiac damage

increased blood viscosity