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Path 1 > MT-Eicosanoids > Flashcards

MT-Eicosanoids Flashcards

1
Q

COX-1 and COX-2 inhibit

A

cyclooxygenase

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2
Q

NSAIDs inhibit

A

cyclooxgenase

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3
Q

cell membrane to Arachidonic acid

A

phospholipases

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4
Q

phospholipases are inhibited by

A

corticosteroids

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5
Q

Arachidonic acid to 5-HPETE

A

5-Lipoxygenase

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6
Q

12-lipoxygenase

A

5-HPETE to Lipoxin A4 / Lipoxin B4

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7
Q

Lipoxins

A

vasodilation
stimulate monocyte adhesion
inhibit neutrophil chemotaxis

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8
Q

cellular component of inhibition of Lipoxins

A

inhibiting neutrophil chemotaxis

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9
Q

leukotrienes C4, D4, E4

A

vasoconstriction
Bronchospasm
Increased permeability

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10
Q

leukotrienes do what to contribute to vascular component of inflammation

A

increase permeability of BVs

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11
Q

prostacyclin PGI2 causes

A

Vasodilation

inhibits platelet aggregation

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12
Q

Thromboxane A2 causes

A

Vasoconstriction

promotes platelet aggregation

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13
Q

______ and _____ are antagonistic

A

prostacyclin PGI2, Thromboxane A2

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14
Q

PGD2, PGE2, PGF2

A

vascular components of inflammation

via promoting vasodilation and edema

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15
Q

PGD2 is secreted by _____ and the _____

A

mast cells, brain

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16
Q

involved in type 1 hypersensitivity and asthma, also inhibits hair growth

A

PGD2

17
Q

functions of PGE2

A

hyperalgesia, fever, uterine contraction, relaxation of cervix for labor

18
Q

stope production of progesterone and induces labor

A

PGF2a (corpus luteum)

19
Q

____ are arachadionic acid metabolites

A

eicosanoids

20
Q

major producers of eicosandoids are _____ and _____

A

neutrophils, macrophages

21
Q

Cox-1 inhibitors

A

NSAIDS

22
Q

regulate amount of fluid and salt in kidneys

protect GI tract from ulceration and irritation

A

Cox-1 functions

23
Q

what happens if COX-1 is inhibited for long periods of time

A

stomach ulterations/irritation (increase in HCL)

kidney problems

24
Q

only used when inflammation is necessary

A

COX-2

25
Q

Inhibitors of COX-2 only

A

Vioxx, celebrex, meloxicam

26
Q

Vioxx is not used because it can result in

A

MI, thombosis, throboaneurysm

27
Q

Tumor necrosis factor (TNF) is produced by ______

A

activated macrophages

28
Q

TNF induces

A

acute inflammatory response

29
Q

TNF is inhibited by medication for

A

RA, akylosing spondylitis (shots are very effective)

30
Q

TNF inhibition may lead to______

A

lymphomas

31
Q

IL-1, IL-6 produced by helper T-cells and induce an acute ________ response

A

inflammatory

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