Path 9 Drugs, Metabolic, Tumors

Question 1

Acetaminophen toxicity

Answer 1

CYP 450 produces toxic metabolites

-Zone III necrosis around central vein

Question 2

Centrilobular necrosis causes

Answer 2

• Acetaminophen
• Carbon tetrachloride
• Halothane
• Ischemia

Question 3

Steatosis causes

Answer 3

• Methotrexate
• Ethanol
• Corticosteroids
• Total parental nutrition

Question 4

Reye syndrome

Answer 4

• Mitochondrial dysfunction
• Aspirin in children
• Microvesicular steatosis and hepatic encephalopathy

Question 5

Fat stain

Answer 5

Oil red O

Question 6

Alcoholic liver disease cause

Answer 6

Acetaldehyde metabolite

Question 7

1 cause of unknown hepatitis

Answer 7

Nonalcoholic fatty liver disease

Question 8

Mallory bodies

Answer 8

Damage to keratin skeleton

-Pink clumps, surrounded by inflammatory cells

Question 9

Primary Hemochromatosis

Answer 9

Recessive

• HFE gene mutation
• C282Y mutation

Question 10

Secondary hemochromatosis

Answer 10

Due to transfusions

-Via free radical damage

Question 11

Wilson disease

Answer 11

Mutated ATP7B gene (ch. 13)

• Decreased serum ceruloplasmin
• Rhodamine (copper) stain
• Tx with D-pencillamine

Question 12

Alpha-1 Antitrypsin Deficiency

Answer 12

AAT is a protease inhibitor
-PiM is normal
-PiZZ is homozygous fucked up
PAS stain inclusions

Question 13

Focal nodular hyperplasia

Answer 13

Benign lesion

• Central scar with vessels and lymphocytic inflammation
• Contraceptives implicated

Question 14

Von Meyenberg Complexes

Answer 14

Dilated bile duct hemartoma clusters in fibrous stroma

Question 15

Cavernous hemangioma

Answer 15

Benign lesion

Question 16

Hepatic adenoma

Answer 16

Benign

• Young women on contraceptives
• No central scar
• May rupture

Question 17

Hepatoblastoma

Answer 17

Malignant tumor of childhood

Question 18

Hepatocellular Carcinoma

Answer 18

• Aflatoxin (moldy peanuts)

- Elevated serum alpha fetoprotein