Micro 4 Camp, Vib, C Diff Flashcards
Campylobacter (C. Jejuni) appearance
G- rods
Curved or spiral
Campylobacter transmission
Contaminated poultry
Campylobacter clinical
Inflammatory diarrhea
Campylobacter culture
Yes
Campylobacter Tx
- Fluid & Salt
- Fluoroquinolones for immunocompromised
Campylobacter complications
- Guillan-Barre
- Reiters syndrome
- Reactive arthritis
- Conjuctivitis
- Urethritis
Vibrio (V. Cholerae) appearance
G- rods
Comma shaped
Vibrio culture
Yes
Vibrio transmission
Water with feces
Shellfish
Vibrio lifecycle
Biofilm survival in water, stomach acids release biofilms
Vibrio cholerae clinical
Watery diarrhea (rice water)
Cholera outbreaks similar to
Typhoid fever (salmonella typhi)
V. Cholera virulence
Pili attach to intestinal cells
Vibrio cholera toxins
A-B
B binds to gangliosides, opens for A
A catalyses ADP-ribosylation, activates adenylate cyclase, massive outflow of salt and water
Vibrio diarrhea type
Secretory (adenylate cyclase)
Cholera Tx
- Fluid & Salt
- Fluoroquinolones or tetracyclines for compromised
Vibrio vulnificus clinical
- Mild cholera-like diarrhea
- Skin infections, bullae (coral)
Vibrio vulnificus diarrhea Tx
-Fluoroquinolones or doxycycline for compromised
Vibrio vulnificus Skin Tx
-Doxycycline/Ceftriaxone or fluoroquinolones
Claustridium difficile transmission
5% normal flora, 20% nosocomial
C. difficile symptoms
- Beta-lactam or clindamycin associated inflammatory diarrhea
- Pseudomembranous colitis
C. difficile toxins
- Toxin A (enterotoxin) induces cytokines and causes fluid secretion
- Toxin B (cytotoxin) interferes with cytoskeleton
C difficile culture
No
Elisa or PCR stools for toxins
C difficile Tx
- Fluid & Salt
- Vancomycin or metronidazole
- Poop transplant
C difficile chance of relapse
20% (due to spores)
