Micro 4 Camp, Vib, C Diff

Question 1

Campylobacter (C. Jejuni) appearance

Answer 1

G- rods

Curved or spiral

Question 2

Campylobacter transmission

Answer 2

Contaminated poultry

Question 3

Campylobacter clinical

Answer 3

Inflammatory diarrhea

Question 4

Campylobacter culture

Answer 4

Yes

Question 5

Campylobacter Tx

Answer 5

• Fluid & Salt

- Fluoroquinolones for immunocompromised

Question 6

Campylobacter complications

Answer 6

• Guillan-Barre
• Reiters syndrome
  
  • Reactive arthritis
  • Conjuctivitis
  • Urethritis

Question 7

Vibrio (V. Cholerae) appearance

Answer 7

G- rods

Comma shaped

Question 8

Vibrio culture

Answer 8

Yes

Question 9

Vibrio transmission

Answer 9

Water with feces

Shellfish

Question 10

Vibrio lifecycle

Answer 10

Biofilm survival in water, stomach acids release biofilms

Question 11

Vibrio cholerae clinical

Answer 11

Watery diarrhea (rice water)

Question 12

Cholera outbreaks similar to

Answer 12

Typhoid fever (salmonella typhi)

Question 13

V. Cholera virulence

Answer 13

Pili attach to intestinal cells

Question 14

Vibrio cholera toxins

Answer 14

A-B
B binds to gangliosides, opens for A
A catalyses ADP-ribosylation, activates adenylate cyclase, massive outflow of salt and water

Question 15

Vibrio diarrhea type

Answer 15

Secretory (adenylate cyclase)

Question 16

Cholera Tx

Answer 16

• Fluid & Salt

- Fluoroquinolones or tetracyclines for compromised

Question 17

Vibrio vulnificus clinical

Answer 17

• Mild cholera-like diarrhea

- Skin infections, bullae (coral)

Question 18

Vibrio vulnificus diarrhea Tx

Answer 18

-Fluoroquinolones or doxycycline for compromised

Question 19

Vibrio vulnificus Skin Tx

Answer 19

-Doxycycline/Ceftriaxone or fluoroquinolones

Question 20

Claustridium difficile transmission

Answer 20

5% normal flora, 20% nosocomial

Question 21

C. difficile symptoms

Answer 21

• Beta-lactam or clindamycin associated inflammatory diarrhea
• Pseudomembranous colitis

Question 22

C. difficile toxins

Answer 22

• Toxin A (enterotoxin) induces cytokines and causes fluid secretion
• Toxin B (cytotoxin) interferes with cytoskeleton

Question 23

C difficile culture

Answer 23

No

Elisa or PCR stools for toxins

Question 24

C difficile Tx

Answer 24

• Fluid & Salt
• Vancomycin or metronidazole
• Poop transplant

Question 25

C difficile chance of relapse

Answer 25

20% (due to spores)