Path 6 Biliary Tract Flashcards
1
Q
CCK role
A
Gallbladder contraction
2
Q
Cholelithiasis
A
Gall stones
-Cholesterol, Bilirubin, Calcium salts
3
Q
Cholelithiasis risk factors (4)
A
- Chronic hemolysis (increased bilirubin)
- Crohns (bile salt malabsorption)
- Biliary tract infection
- Cirrhosis
4
Q
3 stone locations
A
Cholelithiasis (cystic)
Hepatolithiasis (hepatic)
Choledocholithiasis (common)
5
Q
Biliary Colic
A
- Gall obstruction
- Spasmodic RUQ pain
- Tx with cholecystectomy
6
Q
Cholesterolosis
A
- Strawberry gallbladder
- Lipid-containing macrophages in lamina propria
7
Q
Polypoid cholesterolosis
A
Foamy macrophages forming polypoid excresences
8
Q
Acute cholecystitis clinical
A
- RUQ rigidity, pain to right shoulder
- Increased WBC
- Increased serum Alkaline Phosphatase
9
Q
Chronic cholecystitis clinical
A
- Fatty food intolerance
- Nausea, vague RUQ pain
- Cancer risk
10
Q
Differentiate acute from chronic
A
- Always enlarged
- Fibrinous serosa
- Neutrophils v. eosinophils
- Turbid v. normal bile
11
Q
Chronic cholecystitis histology
A
- Rokitansky-Aschoff sinuses
- Mucosal outpouchings
12
Q
Porcelain gallbladder
A
- Chronic inflammation -> calcium
- Carcinoma risk
13
Q
Gene for choledocholithiasis
A
-MDR3 gene (impaired biliary phospholipid secretion)
14
Q
Charcot’s triad
A
Cholangitis
- Intermittent abdominal pain
- Spiking fever with chills
- Jaundice
15
Q
Perinatal biliary atresia
A
- Normal biliary tree destroyed at birth
- Jaundice in 2 weeks
