Micro 7 H. Pylori Flashcards
Helicobacter pylori micro
G- spiral (like campylobacter)
-urease
H.pylori cancer risk
- Gastric carcinoma
- Gastric B-cell lymphoma
H.pylori pathogenesis
- Penetrate mucus with spiral flagella
- Kill cells with cytotoxin and ammonia (via urease)
H.pylori virulence (4)
- Flagella
- Adhesins
- Urease
- Cytotoxin
H.pylori Dx
Urease breath test
Biopsy
H.pylori Tx
- PPI
- Bismuth
- Amoxicillin and Clarithromycin
Listeria monocytogenes micro
G+ coccobacillus on short chains
- B hemolytic
- Blue-green colonies on oblique light
- Grow and replicate at 4 degrees
Listeria transmission
- Cold cuts and hot dogs
- Childbirth
- Soil, water, animals
Listeria neonatal disease
- Granulomatosis infantiseptica (in utero infection of fetus, very dangerous)
- Meningitis & sepsis (birth exposure)
Listeria adult disease
- Febrile noninflammatory gastroenteritis (Pregnant, immunocompromised, elderly)
- Meningitis (Cancer, renal transplant pt)
- Bacteremia
Listeria virulence
Listeriolysin O and phospholipases
-Disrupt phagocytic vacuole, recruit actin to get into adjacent macrophage
Listeria Dx
Culture, NOT gram stain
Listeria Tx
Ampicillin
+Gentamicin for meningitis
Esophageal infections
-Thrush, vesicles, multi-system
- Candida
- HSV
- CMV
Trypanosoma cruzi (chagas) infection
- Megaesophagus or megacolon (neuron loss)
- Bolivia
Food poisoning via enterotoxin
S. aureus, B. cereus, C. perfringens
Bacillus cereus food poisoning
- Fried rice
- Nausea, vomiting, diarrhea
Claustridia perfringens food poisoning
- Beef, poultry, gravy
- Cramps, diarrhea, NO vomiting
Staph aureus food poisoning
- Potato or egg salad, meat
- Nausea, vomiting, diarrhea
Claustridia botulinum transmission
- Canned foods (hardy spores)
- Honey (infants)
- Wound infection
C. botulinum disease
- Descending flaccid paralysis
- Fixed pupils, dysphagia, dizziness
Botox MOA
Irreversable block of Ach release
C. botulinum Dx
Clinical, toxin test
C. botulinum Tx
Antitoxin, symptom support
-Penicillin for wound infection
