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Test 8 > Micro 2 Enterics > Flashcards

Micro 2 Enterics Flashcards

1
Q

Micro for all

A

Fac. anaerobic G- rods

  • All ferment glucose
  • Oxidase negative
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2
Q

Normal flora lactose fermenters

A

Klebsiella

Enterobacter

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3
Q

MacConkey’s gel

A 
Pink = Lactose fermenting
White = non
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4
Q

Non-lactose fermenters

A
  • Salmonella
  • Shigella
  • Yersinia
  • Proteus
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5
Q

Antigen serotypes

-O, H, K

A
  • O- lipopolysaccharide
  • H- Flagellar
  • K- Capsular
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6
Q

Acute diarrhea def.

A

<4 weeks

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7
Q

Enterotoxin v Cytotoxin diarrhea

A

Noninflammatory v Inflammatory

Proximal v Distal

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8
Q

Virus of newborns

A

Rotavirus

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9
Q

Parasitic noninflammatory diarrhea

A

Giardia, Cryptosporidium

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10
Q

Enteric fever def.

A

Bacteremia, fever, headache, rash, splenomegaly, inflammatory diarrhea

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11
Q

Enteric fever bacteria

A

Salmonella typhi

Yersinia enterocolitica

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12
Q

Shigella micro

A

G- rod

No capsule, no lactose

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13
Q

Shigella transmission

A

Food handlers

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14
Q

Shigella disease

A

Dysentery if severe

Enterotoxin from all infections (noninflammatory)

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15
Q

Shiga toxin

A
  • S. dysenteriae and EHEC
  • B binds to cell
  • A inhibits protein synthesis (lyse ribosome)
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16
Q

Shigella virulence

A

-Plasmid via type III secretion

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17
Q

Shigella pathogenesis

A

Intracellular growth via endocytosis, invade adjacent cells, host cells turn into mucosal abscess

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18
Q

Hemolytic Uremic Syndrome

A
  • Hemolytic anemia, Uremia (kidney failure), Thrombocytopenia
  • Caused by Shiga toxin
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19
Q

Shigellosis Dx

A

Stool culture, toxin screen

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20
Q

Shigellosis Tx

A

Fluoroquinolone if severe

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21
Q

Shigella resistance mechanism

A

Plasmid (transfers to/from e.coli)

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22
Q

Salmonella lactose

A

No

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23
Q

Salmonella transmission

24
Q

Salmonella subtypes

A

Typhoidal & nontyphi

25
Salmonellosis
Gastroenteritis (occasional blood), vomiting
26
Salmonella Dx
Stool culture if necessary
27
Salmonella Tx
None
28
Typhoid fever
- Salmonella typhi, Yersinia - Positive blood culture - Affect kidney, liver, spleen, gall bladder
29
Yersinia lactose
No
30
Yersinia transmission
Pigs Scandinavia (denmark) Blood transfusion (rare)
31
Yersinia entercolitica
Gastroenteritis, can cause typhoid fever (bacteremia, rash, joint pain)
32
Yersinia
Blood culture for bacteremia | Stool culture if necessary
33
Yersinia Tx
- Gastroenteritis - none | - Bacteremia - Fluoroquinolone or TMP/sulfa
34
Non lactose fermenters
Salmonella Shigella Proteus Yersinia
35
Lactose fermenters
Klebsiella Enterobacter Escherichia coli
36
E.coli Glucuronidase and Sorbitol
All strains metabolize except EHEC (shiga toxin)
37
Flask shaped ulcer
E.histolytica
38
Escherichia coli micro
- G- rod | - Ferment glucose and lactose
39
E.coli normal flora?
Yes (except EHEC)
40
E.coli producing shiga toxin
Enterohemorrhagic (EHEC, STEC)
41
EHEC transmission
Beef
42
E.coli most common infection
UTI
43
E.coli K1 most common infection
Meningitis in neonates
44
ETEC (enterotoxigenic) infection | -virulence
Traveler's diarrhea (watery) | -plasmid- enterotoxins (secretory cAMP, osmotic cGMP)
45
EPEC (enteropathogenic) infection | -virulence
Infant diarrhea in 3rd world | -plasmid- destruction of microvilli
46
EIEC (enteroinvasive) most common infection
Mild shigella-like dysentery in 3rd world
47
EAEC (enteroaggregative) infection | -virulence
Chronic diarrhea in immunocompromised | -Fimbriae
48
EHEC clinical
- Watery, non-bloody diarrhea - 25% dysentery - 10% hemolytic uremic syndrome (hemo anemia, kidney failure, low platelets)
49
E.coli K1 virulence
Special capsule
50
E.coli virulence
Capsule, pili, adhesion
51
EHEC virulence
- Shiga-like Vero toxins on lysogenic phage | - Hemolysins
52
O157:H6
EHEC
53
Differentiate EHEC from other E.coli
Cannot ferment sorbitol
54
E.coli Tx methodology
- fluoroquinolones - don't Tx EHEC - Tx ETEC (traveler's) early
55
Proteus mirabilis
UTI | -Urease raises pH of urine, promotes stone formation

Test 8 (21 decks)

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