PARVOVIRIDAE Flashcards
Parvoviridae is non-enveloped. True or False?
True
Viral replication and capsid asssembly of Parvoviridae take place in the ?
Nucleus
Replication require host cell functions of ___ phase of the cell division.
S phase
Describe the replication of Parvoviridae.
Rolling-hairpin replication; require rapidly-dividing cells
Parvoviridae has single-stranded DNA. True or False?
True
Give the pathogenesis of Feline panleukopenia virus (carnivore protoparvovirus 1).
- Entry via oropharynx
- Virus replicates in pharyngeal lymphoid tissue
- Targets rapidly dividing cells (e.g. intestinal crypt epithelium, lymphoid tissues)
Give the clinical signs of Feline panleukopenia virus.
- Leukopenia
- Fever up to 40 C, vomiting diarrhea, dehydration
- Perinatal infection: Cerebellar hypoplasia/atrophy syndrome ; ataxia
What are animals that can be infected with Feline panleukopenia virus?
- Viverridae (e.g. civet)
- Procyonidae (e.g. raccoon)
- Mustelidae (e.g. stoat, ferret, weasel)
- Raccoon (Procyon lotor)
- Mink (Mustela)
- Coatimundi (Nasua)
What are the clinical signs of Canine parvovirus?
- Enteritis; vomiting, hemorrhagic diarrhea, dehydration; anorexia, lethargy
- Myocarditis: sudden death in pups (now rare due to maternal immunity)
Give the pathogenesis of Canine parvovirus.
- Targets intestinal crypt cells, lymphoid tissue, and (rarely) neonatal myocardium: intestinal lesions, subsequent mucosal collapse, maldigestion, and malabsorptoin diarrhea
- Myocardial necrosis and inflammation resulting in pulmonary edema and/or hepatic congestion from acute heart failure
— Eccentric hypertrophy (dilated cardiomyopathy) occurs in pups that survive for some time, with associated lympocytic myocarditis and myocardial fibrosis
What are the animals that can be infected with Canine parvovirus?
- All members of the family Canidae
- Many members of Order Carnivora
- Mustelidae and Felidae (e.g. cats, mink, and ferrets, raccoons)
What are the clinical signs of Porcine parvovirus?
- “Endocrinologically pregnant”, not returning to estrus until after the expected time of farrowing
- SMEDI (stillbirth, mummification, embryonic death, infertility)
- Vesicular disease of the feet and mouth
What is the pathogenesis of Parvovirus?
- <30 days gestation: Embryonic death, resorbed
- 30-70 days: Fetus often fails to develop an immune response; dies
- 70 or more days: Lesions; immune response; survival
What are the animals infected by Porcine parvovirus?
Swine
