CALICIVIRIDAE

Question 1

Caliciviridae has envelope. True or False?

Answer 1

True

Question 2

Describe the genome of Caliciviridae.

Answer 2

Single-stranded, positive-sense RNA

Question 3

Describe the morphology of Caliciviridae.

Answer 3

Have cup-shaped surface depressions (Latin calix = cup) or are fuzzy in appearance

Question 4

Caliciviridae host range is highly restricted. True or False?

Answer 4

False, infects broad variety of animals

Question 5

Caliciviridae causes what general diseases?

Answer 5

• Enteric
• Oral cavity
• Upper respiratory
• Systemic ds.

Question 6

Caliciviridae grows well in cell culture. True or False?

Answer 6

False, difficult to isolate in cell culture

Question 7

Since Caliciviridae lack envelope, they are resistant to ?

Answer 7

Lipid solvents and standard detergentbased disinfectants

Question 8

Caliciviridae can be inactivated by solution of ?

Answer 8

10% sodium hypochlorite

Question 9

Genus Vesivirus causes ____ or ____ vesicles.

Answer 9

mucosal; cutaneous vesicles
* “blisters”

Question 10

Genus Lagovirus causes what ds.?

Answer 10

• Rabbit hemorrhagic ds.
• European brown hare syndrome virus

Question 11

Genus Norovirus is associated with what ds. in humans?

Answer 11

Acute gastroenteritis, enteric infections

Question 12

What are the 5 generas of Caliciviridae?

Answer 12

1. Vesivirus
2. Lagovirus
3. Norovirus
4. Sapovirus
5. Nebovirus

Question 13

Vesicular exanthema of swine virus belongs to what genus?

Answer 13

Genus Vesivirus

Question 14

San Miguel sea lion virus belongs to what genus?

Answer 14

Genus Vesivirus

Question 15

Feline calicivirus belongs to what genus?

Answer 15

Genus Vesivirus

Question 16

Vesicular exanthema of swine mimics what ds. in swine?

Answer 16

FMD

Question 17

Vesicular exanthema of swine is eradicated from domestic swine in US by what year ?

Answer 17

1956

Question 18

What is the transmission mode of Vesicular exanthema of swine?

Answer 18

• Direct contact with infected pigs
• Contaminated feed

Question 19

What are the clinical signs of Vesicular exanthema of swine?

Answer 19

• Formation of vesicles on the snout, tongue, and teats, within the oral cavity and on the
  feet
• Lameness – typically the first sign

Question 20

What are the diagnostic methods for Vesicular exanthema of swine?

Answer 20

• Virus isolation
• Various serologic tests
• Electron microscopy to demonstrate
  characteristic calicivirus particles
• RT-PCR assay

Question 21

What are the clinical signs of San Miguel sea lion virus?

Answer 21

• Formation of oral vesicles in infected marine mammals
• Vesicles on the flippers of
  pinnipeds

Question 22

Feline calicivirus is the common cause of what infections ?

Answer 22

1. Oral cavity infection
2. Upper respiratory infection

Question 23

What are natural transmission modes of Feline Calicivirus?

Answer 23

• Fomites
• Direct contact

Question 24

Feline calicivirus is principally shed in what secretions ?

Answer 24

Oral secretions

Question 25

What are the clinical signs of Feline calicivirus?

Answer 25

* acute conjunctivitis * rhinitis * vesiculation and ulceration of the oral epithelium including tongue * **oral ulceration** - most consistent sign

Question 26

Rabbit hemorrhagic ds. is highly infectious for ?

Answer 26

Oryctolagus cuniculus (European rabbit)

Question 27

What are the clinical signs of Rabbit hemorrhagic ds.?

Answer 27

* Hemorrhages within the lungs and liver of affected rabbits * Rabbits can have a **serosanguineous or bloody nasal discharge and exhibit nervous signs** * Lesions: nasal hemorrhage, pulmonary congestion, edema, hemorrhage, liver necrosis

Question 28

Rabbit hemorrhagic ds. affects rabbits older than ?

Answer 28

2 months

Question 29

What are the diagnostic methods for Rabbit hemorrhagic ds.?

Answer 29

* Immunohistochemical staining * ELISA * RT-PCR

Question 30

European brown hair syndrome affects what specie ?

Answer 30

Lupus europaeus

Question 31

Murine calicivurses belongs to what genus?

Answer 31

Genus Norovirus

Question 32

What is the transmission route of Rabbit hemorrhagic ds.?

Answer 32

Orofecal route