Parturition (in sheep) Flashcards

1
Q

What is parturition?

A
  • process by which a conceptus is expelled from the uterus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the conceptus?

A
  • its the foetus and the placenta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the gestation period in the sheep?

A

*143-147 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What stimulates parturition?

A
  • a signal from the foetus (foetal stress)
  • cervical softening
  • co-ordinated myometrial contractions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How many stages are there to labour/parturition?

A
  • 3 stages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What happens prior to the 1st stage of parturition (in the days/weeks leading to it)?

A
  • udder development
  • relaxation of pelvic ligaments
  • passing of mucous plug from cervix
  • vulva swelling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How long can the 1st stage of parturition be?

A
  • 2-6 hrs in sheep
  • up to 24hrs in cattle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What happens in the 1st stage?

A
  • regular uterine contractions
  • cervical shortening and dilation occurs
  • foetus enters birth canal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In the 1st stage there is a cervical dilation - what are the two phases involved?

A
  • latent phase = cervix slowly dilates
  • active phase = rapid dilation of cervix
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How long is the 2nd stage of parturition?

A
  • 0.5-2 hrs in sheep
  • up to 4 hrs in cattle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What happens in the 2nd stage of parturition?

A
  • foetus present at vagina
  • abdominal contractions start
  • cervix is completely dilated
  • rupture of membranes
  • complete delivery of foetus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How long is the 3rd stage?

A
  • 5-8 hrs in sheep
  • 2-4 hrs in cattle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What happens in the 3rd stage?

A
  • uterine contractions continue and involution begins
  • delivery of placenta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What may be signs a lamb was dead before stage 2?

A
  • congenital malformation
  • infection
  • placental insufficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What signs suggest a lamb was dead during stage 2?

A
  • anorexia or trauma
  • bradytocia = sloe birthing, dystocia, malpresentation, twins, arthrogryposis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What signs suggest a lamb died after stage 2?

A
  • infection
  • hypothermia
  • exposure
  • trauma
  • blood clot in foetal artery
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What can loss of progesterone cause?

A
  • induced abortion or initiates parturition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What hormone is essential to maintain pregnancy?

A
  • progesterone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Progesterone is a steroid hormone and therefore is a derivative of what?

A
  • cholesterol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the main cause of onset of parturition?

A
  • achieved by foetal stress response
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Once the foetus becomes stressed what is released and what increases?

A
  • ACTH is released
  • cortisol increases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What axis is involved in foetal stress?

A
  • activation of foetal hypothalamic-pituitary-adrenal axis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What does a rise in foetal cortisol lead to?

A
  • leads to decrease in maternal progesterone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the 3 layers of the uterus?

A
  • endometrium
  • perimetrium
  • myometrium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What does the myometrium (muscle layer) consist of?

A
  • smooth muscle fibres
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

In pregnancy oestrogen stimulates what in the myometrium?

A
  • muscle cell hypertrophy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What do muscle cells in the myometrium form?

A
  • muscle cell syncytium electrically coupled via gap junctions (nexuses)
26
Q

Why do we need well coupled syncytium muscle cells in the myometrium?

A
  • because co-ordinated contraction requires simultaneous activation of all muscle cells
27
Q

What type of control are myometrial contractions under?

A
  • under endocrine control
28
Q

As well as smooth muscles what else does myometrial contraction require?

A
  • alterations in the membrane potential
29
Q

For myometrial cells to contract they must be depolarised by what?

A
  • depolarised by 50mV
30
Q

What two things can be used to measure myometrial activity?

A
  • a tocodynamometer (TOCO)
  • electromyography (EMG)
31
Q

What does a TOCO measure?

A
  • measures the pressure during contractions
32
Q

What does an EMG measure?

A
  • measures electrical activity in the muscle
33
Q

Uterine contractions progressively increase in what?

A
  • increase in frequency and amplitude
34
Q

How does spontaneous depolarisation occur before labour?

A
  • low frequency and low amplitude
35
Q

What do prostaglandins stimulate and in response to what?

A
  • stimulates liberation of intracellular calcium for stronger contraction
  • in response to increased oestrogen (and decreased progesterone)
36
Q

What does oxytocin lower the excitation threshold of and in response to what?

A
  • lowers the excitation threshold of the myometrial cells = more likely to trigger
  • released in response to stimulation of the cervix by the foetus known as the Fergusson reflex (positive feedback loop)
37
Q

Where is oxytocin made and secreted from?

A
  • made in the hypothalamus
  • secreted from the pituitary gland
38
Q

What is oxytocin produced by in the hypothalamus?

A
  • produced by neurones of the paraventricular nucleus of the hypothalamus
39
Q

What does oxytocin induce?

A
  • induces contractions of target smooth muscle fibres of the mammary gland and uterus
40
Q

What does oxytocin cause?

A
  • cause contraction of the myoepithelial cells and milk ejection (milk-let-down)
  • cause contraction of myometrium (uterine contractions
41
Q

What happens in brachystasis?

A
  • uterine muscles retract
  • uterine wall thickness
  • uterine volume reduces
42
Q

The uterus is divided into two segments - what are these?

A
  • upper segment = contractile
  • lower segment = passive
43
Q

What is the junction between the contractile and passive uterus called?

A
  • the retraction ring
44
Q

Palpation of the retraction ring can be used how?

A
  • as an indicator of progression through labour
45
Q

What is the cervix job in relation to the foetus?

A
  • retains the foetus in the uterus
46
Q

What is the cervix composed of?

A
  • composed of lots of connective tissue
  • multiple collagen fibre bundles
  • proteoglycan matrix
47
Q

What does the structure of the cervix allow for during pregnancy?

A
  • during pregnancy this means that it can resist stretch so as the foetus grows and the uterus distends, the cervix remains closed
48
Q

The cervix needs to soften to allow the foetus out during parturition - how is this done?

A
  • reducing collagen fibres
  • increasing proteoglycan matrix
  • under hormonal control
49
Q

What hormones does the cervix produce?

A
  • prostaglandin E2 (PGE2)
  • prostacyclin (PGI2)
  • prostaglandin F2a (PGE2a)
50
Q

What softens the cervix?

A
  • prostaglandins
51
Q

Prostaglandins act to do what?

A
  • breakdown collagen
  • stimulate uterine contraction
52
Q

During pregnancy how does progesterone inhibit PG production?

A
  • by blocking phospholipase A2, required in prostaglandin synthesis
53
Q

What does oestrogen liberate (switch on)?

A
  • phospholipase A2
54
Q

What is ring womb?

A
  • failure of the cervix to soften and dilate with normal uterine contractions leading to inability to birth foetus naturally
55
Q

What is ring worm caused by?

A
  • lack of prostaglandin production
  • lack of prostaglandin receptors
  • linked to selenium deficiency
  • genetic component
56
Q

What is the treatment for ring womb?

A
  • prostaglandin gel to cervix (not sheep)
  • caesarean section
  • in farm animals cull (potential genetic)
57
Q

What is false ring womb?

A
  • cervix dilation slow/partial with normal uterine contractions leading to inability to birth foetus naturally
58
Q

What is false ring womb caused by?

A
  • contraction of muscles around cervix
  • can palpate a tight ring at cervix
59
Q

What is false ring womb associated with?

A
  • premature intervention by shepherd
  • malpresentation of lamb (not pressing on cervix)
60
Q

What is the treatment for false ring womb?

A
  • gentle stretching/manipulation with fingers
  • can take up to 45 mins
61
Q

When do vaginal (and cervical) prolapse usually occur?

A
  • last month of pregnancy
62
Q

What are vaginal (and cervical) prolapse linked to?

A
  • obesity
  • multiple/large foetus
  • high fibre diet
  • limited exercise
63
Q

What complications can a vaginal and cervical prolapse cause?

A
  • abortion
  • ring womb at parturition
  • prolapse again at parturition
  • uterine prolapse at parturition
64
Q

What methods can be used for vaginal and cervical prolapse?

A
  • replace the prolapse
  • suture vulva
  • retention spoon
  • prolapse harness
  • cull after parturition and don’t use offspring for breeding