Parkinson's drugs Flashcards
1
Q
How is dopamine synthesised?
A
Tyrosine converted to L-dopa
L-dopa decarboxylated to dopamine
Loaded into presynaptic vesicles
2
Q
What enzyme metabolises dopamine?
A
MAO (type B)
COMT
3
Q
What must levodopa be co-administered with?
A
Carbidopa; inhibits dopa decarboxylase and reduced peripheral conversion
4
Q
What is the mode of action of entacapone?
A
Inhibits peripheral COMT (prevents peripheral conversion)
5
Q
Examples of direct dopamine agonists?
A
Bromocriptine
Ropinirole
6
Q
What nT is increased in parkinson’s disease?
A
Reduced dopamine results in increased ACh
Overstimulation of muscarinic receptors results in tremors and rigidity
