Parkinson's disease Flashcards
which neurotransmitter is implicated?
dopamine
which pathway is effected?
nigrostriatal pathway
dopaminergic neurones die in which part of the brain?
the above structure falls under which larger group of structures?
substantia nigra pars compacta
basal ganglia
what is the aetiology?
idiopathic
what is seen on histology?
Lewy bodies in substantia nigra
where does parkinson’s rank in the most common neurodegenerative disorders?
2nd
what is the most common neurodegenerative disorder?
Alzheimer’s
which gene is involved?
LRKK-2 gene
which gender is a RF?
males
the basal ganglia is mainly responsible for what?
movement
basal ganglia enables subconscious control of what property in skeletal muscles?
tone
a person want to move.
Dopamine in the direct pathway does what?
stimulates desired contracting muscle
a person want to move.
dopamine in the indirect pathway does what?
inhibits antagonistic muscle
what are the 4 main movement symptoms?
Bradykinesia
Resting Tremor
Rigidity
Postural instability
what are the non-movement symptoms?
-6
Sleep troubles Depression, anxiety, dementia Constipation Anosmia
why is there tremor and rigidity?
Dopamine & ACh balance is thrown off. ( ↓[dopamine] )
Resting tremor is exacerbated and alleviated by what?
worse when tired
better with movement.