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Neurology > brain tumours; glioblastoma and meningioma > Flashcards

brain tumours; glioblastoma and meningioma Flashcards

1
Q

Most common 1° brain tumour?

A

Glioblastoma

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2
Q

Most malignant glial tumour?

A

Glioblastoma

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3
Q

Cause of glioblastoma?

A

unknown

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4
Q

Histology of glioblastoma?

A

Pleomorphic tumour cells border necrotic areas

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5
Q

Risk factors for glioblastoma?

A

radiation

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6
Q

Where do glioblastoma comes from?

-2

A

normal glial cells or pre-existing astrocytoma

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7
Q

Ix of choice for glioblastoma?

what features are you looking for?
-3

A

MRI

tumour with central necrosis
rim that enhances with contrast
oedema.

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8
Q

why is there oedema in glioblastoma?

A

BBB gets disrupted

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9
Q

medication given to treat oedema in glioblastoma?

A

Dexamethasone

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10
Q

symptoms of glioblastoma?

A

Neuro deficit
Motor weakness
Headache
Seizures

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11
Q

↑ICP in glioblastoma can cause what symptoms?

-3

A

Headache
N&V
cognitive impairment (low GCS)

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12
Q

main stay treatment for glioblastoma?

A

surgical resection + post op chemotherapy/radiotherapy

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13
Q

which chemotherapeutic agent is oft used in glioblastoma?

A

Temozolomide

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14
Q

Temozolomide is used in what brain cancers?

A

glioblastomas and astrocytomas

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15
Q

moa of temozolomide?

A

damages DNA causing cell death

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16
Q

temozolomide class?

A

alkylating agent

17
Q

Meningioma comes from what meninge?

A

dura mater

18
Q

meningioma is typically benign or cancerous?

A

benign

19
Q

meningioma are intrinsic or extrinsic cancers of CNS?

A

extrinsic

20
Q

where does meningioma rank in the most common primary brain tumours?

A

2nd

21
Q

Histology of meningioma?

-2 features

A

Spindle cells in concentric whorls and calcified psammoma bodies

22
Q

which medical therapy is a risk factor for meningioma?

A

Radiotherapy

23
Q

Risk factors for meningioma?

-3

A

Age
FHx/genes
Radiotherapy

24
Q

symptoms of meningioma are caused by invasion or compression?

A

compression

25
Q

symptoms of meningioma?

A

Headache
Seizure
Neuro deficit

26
Q

why are there seizures in meningioma?

A

because meninges are irritated

27
Q

why are there headachesin meningioma?

A

Compression

28
Q

if meningioma compresses spinal cord, what syndrome might you get?

A

Brown Sequard syndrome

29
Q

what happens to ICP in meningioma?

A

increases

30
Q

you do fundoscopy on pt with meningioma.

what might you see?

why?

A

Papilloedema

↑ICP

31
Q

Ix of choice for meningioma?

A

MRI

32
Q

2nd line imaging for meningioma?

A

CT

33
Q

Usual Mx of meningioma?

A

surgical resection

34
Q

pt has meningioma, but surgery is not possible.

what is 2nd line Mx?

A

radiotherapy

35
Q

pt has meningioma and is asymptomatic.

what is the Mx?

A

observe

Neurology (40 decks)

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