BZD overdose benzodiazepines Flashcards
BZD has what effect on CNS?
depresses it
uses for BZD
-4
insomnia, seizure, anxiety, rapid transquilisation
which BZD is good in the acutely agitated?
and why?
lorazepam
quick effect
BZD has what effect on what neurotransmitter?
is this neurotransmitter excitatory or inhibitory?
↑GABA
inhibitory
most lethal complication of BZD overdose?
respiratory depression
what is classical triad of symptoms from BZD overdose?
respiratory depression + ataxia + low consciousness
main sign on doing news chart?
low O2
ABG result on pt with BZD overdose?
resp acidosis
GCS score is high or low on BZD overdose?
GCS low
1st line Mx for BZD overdose?
IV fluids
2nd Line Mx for BZD overdose?
is this option regularly done?
FLUMAZENIL
no, rare to do
drug to treat BZD overdose?
Flumazenil
moa of flumazenil?
BZD antagonist
major SE of flumazenil?
seizures
pt has severe resp depression.
What is Mx?
mechanical ventilation
why are older people at high risk of any overdose
Reduced drug clearance with age
BZD overdose,
what happens to pupil size?
stay same, no effect
opiate overdose,
what happens to pupil size?
constricts
Amphetamines, cocaine, LSD overdose,
what happens to pupil size?
dilates
BZD overdose often causes death.
true or false?
false
