Parkinson Plus Syndromes Flashcards
MSA vs. PD Response to levodopa Progression Falls Symmetry Cerebellar Dysautonomia
MSA - Poor Rapid Early Symettric More common Common more early
MSA is
Multiple system atrophy
MSA main dysfunctions
Cerebellar
CV - orthostatic hypotension
Urogenital dysfunction
MSA features
COld hands
Cold feet
Anterocollis
Pisa syndrome
MSA neuropathology
Glial cytoplasmic inclusions of oligodendrocytes
MSA neuroimaging
PUtaminal slit (increased intensity) Hot corss bunds sign of vermis
MSA tx
Levodopa
PSP features
Slowed vertcial saccades...doll's eye can overcome Square wave jerks Rocket sign Applause sign Progressive supranuclear palsy
PSP which way to fall and other weird thing
Tendency to fall backward (opp of PD)
Pseudobulbar affect
PSP radiographic
Micky mouse more pronounced
Corticobasal syndrome
Alien lymb phenomenon (involuntary purposeful movements)
Ideomotor apraxia (inability to perform skilled motor act despite normal and sensory functioni)
Astereognosis and agraphesthesia
CBD MRI
Posterior lateral and medial frontal cortical atropy with no BS atrophy
CBS and PSP are both
Tauopathies
DLB featues
Progressive cog decline (within a year of parkinsonism)
Fluctuations
Hallucinations
Neuroleptic sensitivty
DLB pathology and tx
Often with Lewy bodies in cortex along with SN
Donepezil (cholinesterase inhibitor)
