PAPOVAVIRUS

Question 1

char aa

Answer 1

Nakes dsdna viruses char as slow growinh.
replicate in nucleaus.

no envelope
resistant to deying freezing and solvents.

Question 2

Warts(verruca)

Answer 2

L1- codes for major capsid protein and self assembles into virus like particles (VLPs)

L2- minor capsid protein. L2 protein help expose the keratinocyte bindingh detweminant of L1 protein allowing hpv to bind onto the basal keratinocyte and taken into the cell.

Question 3

Warts(verruca)

cause vast majority of cutaneous non genital warts

Answer 3

HPV 1,2,27, and 57.

Question 4

Warts(verruca) plantar warts in children younger than 12 yo.

Answer 4

HPV 1

Question 5

Warts(verruca)

Hand

Answer 5

HPV2

Question 6

Warts(verruca)

plantar warts >21 yo.

Answer 6

HPV 27,57

Question 7

Warts(verruca)

external genitalia warts

Answer 7

HPV 6,11

Question 8

Warts(verruca)

anogenital dysplasia

Answer 8

hpv 16/18

Question 9

Warts(verruca)

WHIM Syndrome

Answer 9

Warts hypogammaglobulinemia infection and myelokathexis: gain of function mutation of CXCR4.

Question 10

deficiency of GATA2

present w

Answer 10

Extensive warts.

Question 11

GAT2 deficiency sundrome

Answer 11

WILD syndrome.

Question 12

defIcient CD4, Hyper IGE ,caused by DOCK8 deficiency are 2 other Tbcell immunodef states assoc w

Answer 12

HPV infection

Question 13

VERRUCA VULGARIS

HPV types that cause common warts

Answer 13

HPV 1, 2, 4 ,27, 57, 63

Question 14

VERRUCA VULGARIS

common warts occur most commonly between ages

Answer 14

age 5-20 yo.

and only 15% occur after age 35yo.

Question 15

warts in butches are caused by

Answer 15

HPV2 and 4.

Question 16

27% or hand warts from butchers are caused by

Answer 16

HPV7.

Question 17

HPV… Has been reported to cause dystrophy of all fingernails w marked subungal hyperkeratosis and destruction of nail plate without periungal involvement.

Answer 17

HPV57

Question 18

HPV with higher risk of SCC

Answer 18

HPV 16 and 18

Question 19

clearance rates of common warts.

Answer 19

Spontaneous resolution.

children are 23% at 2 mos. 
30% at 3 mos 
50% at 1 year. 
65-78%  at  2 years. 
90% over 5 years.

Question 20

PIGMENTED WARTS

skin types

Answer 20

Skin type 3 to 6

Question 21

Pigmented warts Caused by HPV types

Answer 21

HPV 4, 60, 65.

Question 22

Pigmented warts

pogmentation is caused by

Answer 22

melanocytes in the basal layer of HPV infectee tissue that contain large amounts of melanin.

Question 23

FLAT WARTS (Verruca Plana) 
caused by hpv type

Answer 23

HPV 3, 10, 28, 41.

Question 24

FLAT WARTS (Verruca Plana) 
present as

Answer 24

2-4mm flat topped ppules tht are slightly erythematous or brown on pale skin and hyperpigmented ok darker skin.
occur kost commonly on sun exposed surfaces likely due to immunosuppression.
face and extremities are most common. spec forehead cheeks nose and area around mouth and backs of the hands. but can occur anywhere.

Question 25

``` FLAT WARTS (Verruca Plana) people that this is common ti ```

Answer 25

swimmers. Autism spectrum disorders. OCD who wash excessively and have dorsal hand dermatitis.

Question 26

of all clinical hpv infections....warte have the highest rate of spontaneous remission and are the nost challenging to treat because they are so flat to the skin. TX OF CHOICE

Answer 26

flat warts. Top. retinoid

Question 27

Plantar warts (verruca plantaris) the ff HPV types cause plantar warts

Answer 27

1, 2, 27, 57

Question 28

``` Plantar warts (verruca plantaris) generally appear at ```

Answer 28

pressure points on the ball of the foot spec over the midmetatarsal area. appear as soft pulpy cores are surrounded by a firm horny ring. plantar warts may be confused w corns or calluses. but warts have a soft central core and black or bleeding points from the superficial capillaries when pared down.

Question 29

occurs as smooth surfaced deep often inflamed and tender papules or plaques mostly on palms or soles butbalso beside or beneath the nails or less often on the pulp of digits. they are distinctively dome shaped and much bulkier beneath the surface than they appear.

Answer 29

Myrmecia type of verruca

Question 30

myrmecia isa caused by

Answer 30

HPV1

Question 31

cauaes a peculiar type of plantar wart caused a ridged wart because of the persistance of the dermatoglyphics accross the surface of the lesion. the warts are slightly elevated, skin colored 3-5mm papules. occur on non weight bearinh areas and lack the typical feat of plantar warts.

Answer 31

HPV-60.

Question 32

Tx

Answer 32

see ph 405