Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

19-Virus > Herpes > Flashcards

Herpes Flashcards

1
Q

most cases orolabial what hsv?

A

hsv1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

hsv for genital herpes

A

Hsv2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

tx orolabial herpes

A

IV ACYCLOVIR 5mg/kg 3x/day.

oral: acyclovir susp15mg/kg 5x daily for 7 days,
Valacyclovir 1g 2x a day for 7days.
Famciclovir 500mg 2x a day for 7 days.

this tx reduced duration or illness by more than 50%.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

most freq clinical manif of orolabial herpes

A

cold sore
fever blister

lips near vermillion are most freq involved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

surgical prophylaxis in pxs w history or orolabial herpes

A

Famciclovir 250mg twice daily,
valacyclovir 500mg twice dail
oral acyclovir 400mg 3x a day

24 hrs prior procedure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

for routine surgeries at sites of hsv recurrence ( upper and lower lip)

A

acyclovir 200mg 5x daily
famciclovir 250mg 3x day
valacyclovir 1g 2x a day
starting 2-5 days before procedure for 5 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

recurrent id initial herpes infections may promarily affext hair follicle

A

Herpetic sycosis

confirmed by biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

under age 25 which is more common hsv 1 or 2?

A

Hsv1 - more than 50% of cases of genital herpes. whereas women over 25 and men of all ages- hsv2.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

of all ages, over 25, men. 1/2?

A

HSV2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

genital herpes inc period

A

5 days.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

risk of transmisison in monogamous couples

A

5-10% annually

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how many percent of hsv2 are symptomatic?

A

57%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

initial clincial episode of genital herpes tx

A

Oral acyclovir 200mg 5x or 400 mg 3x daily.
famciclovir 250 mg 3x daily.
valacyclovir 1000mg twice daily for 7 - 10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

sx genital herpes recurrent

A

prodome burning
Itching and tingling. Usually 24 hours red papules appear at site progress to blisters w clear fluid over 24 hrs, form erosions in net 24-36 hours heal in 2 -3 days.
total duration if a typical outbreak of genital herpes is 7 days.

lesions are usually grouped blisters.

occur in same anatomic rgion
upper buttock common site for recurrent genital herpes in both men and women.

heals wo scarring.

dx of recureentgenital herpes should not be done clinically.
dx best confirmed by- Viral culture pcr dfa Llowing for typing the causative virus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

tx for recurent genital herpes

A

Acyclovir 200mg 5x daily or 800 mg twice a day

famcyclovir 125mg twuce a day for 5days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

in pxs w frequent recurrences (>6-12 yry) suppressive tx is reasonable.

A

acuclov 400 mg 2x a day. 200 mg 3x a day. or 800 mg once a day. will suppress 85% kf recurrences and 20% aill be recurrence free during suppressive tx.
vacyclovir 500/day ( 1000mg/day fkr those >10 recurrences/ year )
Famciclovir 250mg twice dailyp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

85% of neonatal herpes occur when

A

delivery
5% in utero
10-15% non maternal sources after delivery

18
Q

70% kf neonatal herpes are caused by

A

Hsv2

in 68% infected babies, skin vesicles are leesentin sign. and a good sourxe for virus recovery

19
Q

dx of neo herp confirmed by

A

viral culture

70% of mothers of infants w neonatal herpes are asymptomatic

20
Q

risk of infection for an infant del vaginally shen mother has actice recurrent genital herpes

A

2-5%

26-56% if maternal infection at delivery is a 1st episode

scalp electrode/ avaoided. risk of neonatal indefrion by upto 7 fold.

vaccum - 27x risk for neonatal transmission

21
Q

vaccum assit dev inc relative ris of neonatal transmission of hsv2 by how many times

A

27 times

22
Q

which is more freq transmitted intrapartum hsv1 /2?

A

Hsv1

cs is still the recommendarion1 red risk of tramsmision fron 8 to 1 %

23
Q

chronic supp tx w acyclvir has ve used from wht week?

A

36weeka of gest

24
Q

antiviral tx of all initial wpisodes of genital herpes in pregnancy.

A

std acyclovir for initial epc 400 mg 3x a day for 10 days

25
Q

infection kr gerpes w AD. speead of herpes rhroughout eczematous areas

A

Eczema herpeticum (kaposu varicelliform eruption)

bath or hot tub exposure- risk factor.

26
Q

topical drug assoc w EH

A

Topical calcineurin

27
Q

infammatorh mediators assoc w EH

A

IL10, IL19

HLA B7/IL25

28
Q

3 clinical hallmarks of hsv

A

pain
active besicular vorder
scalloped periphery

29
Q

immunocomp hosy most herpetci lesions present as

A

ulcerstive not vesicular

if ulceration does not respond to tx in 48 hours and cultures are negative; a biopsy is recommended

30
Q

std tx of acyclovie resistant herpes simplex

A

IV FOSCARNET.

if intolerant to foscarnet— cidovofir IV.

resistance to one drug is assoc w resistance to all three of the drugs usually from loss of viral thymidine kinase.

31
Q

H of herpes

A

Vesicles epidermal
leukocytosis in dermis
balloning degeneration of epidermal cells prod acantholysis
most char feature muktinycleated gian cells.
steel gray color id nucleaus and peripheral condensation of nucleoplasm

32
Q

size

A

medium sized.
ds dna.
latent but lifelong infection.

33
Q

hav 1 std pxs- rate of infection

A

30-50%

34
Q

hsv 1 and 2 incidence

A

hsv1 - 50%- orolabial lesions
hsv2- 20%- asymptomatic( latent infection)
20% recurrent genital herpes
60% clinical lesions they do not recognize as sx of hsv

35
Q

orL recurrent herpes affects

A

kerstinized surfaces of hard palate

attached gingiva.

36
Q

frequent trigger for recurrent orolabial hsv

A

UV spec UVB

37
Q

in pxs w 6 or more outbreaks per year,

A

suppressive daily antiviral tx can be used.

squaric acid dibutyl ester - immunosenstizer to reduce recurrent outbreaks.

38
Q

herpetic whitlow

A

infectio occur on fingers or periubgually.
begin w tenderness and erythema usually on the lateral nailfold or on the palm. deep seated blisters dev 24-48 hrs after sx begin.
bimodal dist. 20% occur in younger than 10 yrs and 55% bet 20-40.
all cases in child- hsv1.
twice common in women.

39
Q

tx for immunocompromised:

A

Acyclovir 400mg orally 3x a day
famciclovir 500 mg 2x a day
valacyclovir 1g 2x aday
all for a min of 5-10 days.

40
Q

immunocompromised px, w moderate dx tx.

A

IV acyclovir 5mg/kg initialy to control dx.

in aids, and those w persistent immunosupp consideration-
acyclovir 400-800 mg 2 or 3x daily
valacyclovir or famcyclovir 500mg 2x a day.

19-Virus (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions