ALPHA VIRUS Flashcards
Sindbis Virus transmitted by
Culiseta mosquito.
eruption kf multiple erythematous 2-4 mm papules w surrounding halo is assoc w fever and prominent arthralgias. eruption and symptoms resolve over a few weeks.
H: perivascular lymphocytic infiltrate w large atypical cells simulating lymphomatoid papulosis
CD30 does not stain the large cells however allowing their distinction.
Alpha virus-Chikungunya virus
transmitted by
Aedes mosquito
Chikungunya virus means
“that which bends up” desc char stooped posture resultinh drlm joint sx of dx.
incubation
2-7 days.
char
abrupt onset of high fever significant joint sx in 40% of pxs.
most often; swelling and pain in the small joints of the hands and feet.
joint sx may persist for weeks to months.
may dev neuropathic acral findings. inc reynaud phenomenon erythromelalgia or severe acral coldness.
headache 70%
nausea and vomiting 60%
lymphopenia
thrombocytopenia
elevated LFTs
Chikungunya virus
lesions
morbilliform most freq arms upper trunk and face. ca be confluent and islands of sparing.
+Nikolsky sign.
Chikungunya virus spared areas
genitalia palms soles
Chikungunya virus
biopsy
intraepidermal blisyer w acantholytic cells floating free on blister cavity
Chikungunya virus dx
Detct IgM in serum.
confirmation: seroconversion over next several monyhs w IgG.
does torniauet test diff dengue and Chikungunya virus
no. but thrombocytopenia is more common in dengue. 85% or greater than chikungunya (35%) of pxs
Alpha- ZIKA VIRUS
PRIMARY VEctor
Aedes aegypti.
tho a. albopictus may transmit the virus as well.
Zika virus serious birth defects
microcephaly
brain damage
may persist in semen for months?
Yes.
condom use is recommended.
Zika virus presentation
fever rash joint pain and often conjunctivitis
hyperemic sclerae - helpful clue.
rash with pruritus or conjucntival hyperemia without any other signs such as fever petechiae or anorexia may be the best clinical clue to diff zika from other arbovirus.
