EBV

Question 1

number

Answer 1

HHV4

Question 2

infects

Answer 2

gamma.

infects human mucosal epith cells and B lymphocytes. infectioj persists for the life or rhe host.

Question 3

ability of EBV TO MAINtain persistent infection is aided by the expression of the

Answer 3

EBNA1 ( ebv nuclear antigen 1) Viral gene product. wc prevente cytotoxic T lymphocytes response to the virus.

Question 4

most common route of trans

Answer 4

Oral secretions contact

Question 5

inc

Answer 5

3-7 weeks.

Question 6

IM- Infectious mononucleosis

Answer 6

fever upto 40C
headache
lymphadenopathy
splenomegaly
pharyngitis(sore throat)
cutaneous and mucous membrane lesion- 10% of IM pxs.
edema or eyelids and macular morbilliform eruptipn- most common.
trunk and upper extremity- Eruption usually.

painful genital ulceration may predede symptomatic phase of IM. spec premenarcheal girls.

Question 7

may be the cause of non sexually relsted genital ulcers

Answer 7

Lipschutz ulcers

Question 8

lab

Answer 8

absolute lymphocytosis- greater than 50% and monocytosis w abn large “atypical” lymphocytes.
WBC from 10-40,000cells/mm3.
Liver function test may be elevated.
heterophile antibodies- 95% of cases.
IgM and VCA viral Capsid antigen- higher titer and decrease during recovery.

Question 9

Tx of IM.

Answer 9

No tx.
acyclovir is not effective in alt length or severity of IM.

w severe pharyngeal inv w enroaxhment on the airway; or cytopenias or liver failure- Oral steroid tx (40-60mg/day) of prednisone.

Question 10

Almost all pxs w IM tx w Ampicillin, amox, or other semisynthetic penicillin typ develop

Answer 10

a generalized pruritic erythematous to copper colored macular exanthem on the 7-10th day of tx.