FILOVIRUS

Question 1

among kost virulent and hazardous pathogens fro humans and non humans.

2 genera

Answer 1

Marburg  virus (MARC) 
Ebola virus (EBOV) 

incubation 1-21 days.

Question 2

phases of dx

Answer 2

Phase 1 - abrupt onset of fever headache usually occipital myalgias and arthralgias.

phase2- starts 2-4 days after sx onset and last for 7-10 days. abd pain wayery diarrhea and violent sore throat. non pruritic morbilliform eruption resembling measles appears 4-5 days agter sx onset in more than half of pxs. onset of eruption begins as: pinpoint dark red follicular papules. the exanthema begin acrally and spread centripetally to the trunk or vice versa. begunnung proximally and extending centrifugally.
day 8- generalized dark livid erythema eruption resolves over few days in survivors. ff by desquamation of affected skin. spdc of palms and soles. mucosal lesion- half od pxsa bilateral conjunctical congestion aphthous like oral lesions gingivitis glossitisand w extension down the theoat dusphagua.
oral lesions have gray exudate or small tapioca granule white lesions on soft palate.

Phase 111- terminal phase w shock and multiorgan failure.

Question 3

anomal reservoie

Answer 3

• four fruit bat sp found in africa.
  transmissioj occurs in humans thru contact w female bat blood infected non human primates and by contact w bodoly fluids of infected humans.
  infected humans can transmit virus- when they become febrile.

dx: PCR.

Question 4

case fatality rate;

Answer 4

90%