Pain Part 1 Flashcards
external environment information is
sensory
internal environment information is ____ afferent
visceral
4 elementary attributes of stimulus coding
modality
location
intensity
duration
sensory information which we are aware
sensation
understanding of the stimulus
perception
modalities of stimuli
mechanical
light
chemical
temperature
law of specific nerve energies
a given sensory receptor is specific for each modality
chemoreceptors include
taste
smell
pain
chemoreceptors detech pain by
chemicals dissolved in ECF
what detects acceleration
hair cells- mechanoreceptors
sensations from skin, muscles, tendons, joints
somatic sensation
temperature uses ___ proteins
transient receptor potential (TRP)
direct afferent receptor configuration
stimulus acts directly on sensory receptor, opens ion channel, triggers AP
indirect afferent receptor config
stimulus acts on specialized cell, which opens ion channel and triggers an AP
- involves Ca2+ influx
sensory unit
one afferent neuron and all of its sensory receptors
receptive field
area of the receptive surface of an afferent
which receptors are steady pressure
merkel cells
ruffini endings
which receptors are tingling/ vibrations
meissner corpuscle
pacinian corpuscle
which receptors are rapidly adapting
meissner
pacinian
which receptors are slowly adapting
merkel and ruffini
change environmental stimuli into electrical signals
transduction
frequency of AP and population of activated receptors codes
stimulus intensity
somatosensory pathway
first order - synapse in spinal cord - second order - thalamus synapse - third order - cortex
modality is coded through
specialized pathways that project to specific cortices
location is coded through
specific regions of the brain + size of receptive field
where is the best 2 point discrimination found
lips
where is the worse 2 point discrimination found
calf
TRPs are _____ channels
nonselective cation
TRPV1
activated by heat, acids, capsaicin
TRPA1
mechanical, cold, chemical
TRPM8
responds to menthol- cool receptor
acid sensing ion channels are sensitive to _____ and are found on
pH changes
nociceptors