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PSYC475 psychopharm > pain medications > Flashcards

pain medications Flashcards

1
Q

fentanyl

A
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2
Q

oxycodone

A
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3
Q

duloxetine

A
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4
Q

tramadol

A
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5
Q

The cell bodies of nociceptors are found in the

A

dorsal root ganglion of the spinal cord

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6
Q

Fentanyl is at least ______ times more potent that morphine.

A

80

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7
Q

Dull, diffuse pain signals are transmitted via __________ fibers.

A

C

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8
Q

Combining acetaminophen with alcohol is dangerous because it can result in:

A

hepotoxicity

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9
Q

Which of the following drugs is a good choice for “poor metabolizers” or patients with compromised liver function?

A

propoxyphene

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10
Q

Suboxone is the combination of buprenorphine and

A

naloxone

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11
Q

To which receptor does oxycodone bind the most?

A

mu opioid

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12
Q

Inhibition of COX-1 results in

A

upset stomach

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13
Q

Vicodin is a combination of hydrocodone and

A

acetomenophin

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14
Q

Which of the following nuclei is NOT a part of the descending pain modification system?

A

nucleus basalts

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15
Q

NSAIDs

A
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16
Q

aspirin

A
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17
Q

ibuprofen (drug class, trade names)

A

NSAIDs

advil, motrin

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18
Q

naprozen (drug class, trade names)

A

NSAIDs

Aleve, Naprosyn

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19
Q

what is one of the #1 causes of acute liver failure

A

tylenol AKA acetominophen

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20
Q

why don’t take tylenol for a hangover?

A

you still have alcohol in your system —-> liver damage

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21
Q

what is considered one of the most dangerous OTC drugs?

A

tylenol / acetominophen

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22
Q

pros of ibuprofen?

A

not found in breastmilk

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23
Q

pros of toradol

A

concurrent administration can dec morphine requirement

24
Q

issues w indocin (indomethin)

A

inc side effect liability

25
Q

pros of sulindac (clinoril)

A

less GI upset than indomethin

26
Q

pros of diclofenac (voltaren)

A

Several preparations: delayed release, topical, skin patch

27
Q

pros of nabutmeone (relafen)

A

rec for long term tmt; less GI upset vs aspirin

28
Q

cons of celecoxib (celebrex)

A

no cardioprotective effects; may actually inc risk

29
Q

morphine SE?

A

Side Effects: respiratory depression, pupillary constriction, constipation, decreased sex drive/fertility problems, itching

30
Q

codeine is metabolized to…..

_____ can block this transformation

A

morphine ((but SSRIs can block this transformation))

31
Q

hydrocodone is used for…. (2)

A

Mild-Moderate pain, cough suppression

32
Q

Vicodin / norco is _______ mixed with ________

A

hydrocodone ; acetaminophin

33
Q

what is one of the most frequently abused presctiption drugs in the US

A

hydrocodone

34
Q

heroin is _____x the potency of morphine

A

3

35
Q

heroin is ______ soluable

A

lipid

36
Q

hydromorphone / oxymorphone trade name:

A

dilauded , numorphan

37
Q

hydromorphone / oxymorphone is ____-____x potency of morphine

A

6-10x

38
Q

what drugs might inhibit the effects of hydromorphone / oxymorphone? (2)

A

antihistamines & MAOIs

39
Q

merperidine has greater _________ effects than morphine

A

euphoric

40
Q

methadone has a half life of ______hours

A

24-36hrs

41
Q

issues with levo-alpha acetylmaethadol?

A

inc risk of cardiac effects

42
Q

pros of levo-alpha acetylmaethadol?

A

long half life (2.5 days) , Long duration of action allows for less frequent dosing

43
Q

pros of propoxyphene? (2)

A

Effects do not depend on metabolism; good choice for “poor metabolizers”; Less GI upset

Lower risk of dependence

44
Q

fentanyl is _____-_____x as potent as morphine

A

80-500x

45
Q

what is buprenorphine used for?

A

Opioid dependency (suppresses craving, decreased euphoria)

46
Q

pros of buprenorphine

A

Txts opioid dependency without risk of abuse

47
Q

how does tapentadol (nucynta) work?

A

Mu agonist + blocks NET

48
Q

pro of pentazocine?

A

Low risk of dependence or respiratory depression

49
Q

nalmefene (Revex) is similar to naloxone, but _______

A

lasts longer

50
Q

naltrexone is used to ________

A

treat opioid / alcohol dependence

51
Q

methlynaltrexone/alvimopan has _______ effects, because _________

A

only peripheral effects; Does not cross BBB

52
Q

Ibuprofen is an especially good choice for

A

nursing mothers

53
Q

The metabolism of codeine into morphine can be blocked by

A

SSRIs

54
Q

Compared to morphine, heroin is

A

more lipid soluable

55
Q

Dull, diffuse pain signals are transmitted via __________ fibers.

A

C

56
Q

What is the primary indication for acetaminophen?

A

Analgesia and antipyresis

PSYC475 psychopharm (14 decks)

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