anxiolytics

Question 1

buspirone (trade name) is….
class of drug?

Answer 1

BuSpar

Question 2

alprazolam (trade name) is….

class of drug?

Answer 2

Xanax

benzodiazepine

Question 3

venlafaxine (trade name) is….
class of drug?

Answer 3

Effexor

SNRI

Question 4

propanolol (trade name) is….
class of drug?

Answer 4

inderal

beta blocker

Question 5

NT in anxiety

Answer 5

GABA
NE
5HT

Question 6

OCD onset ? co-occurences?

Answer 6

onset usually early childhood; associated w co-occuring tic d/o

Question 7

how is GABA involved in anxiety d/os?

Answer 7

dec GABA fxn (not enough GABA)

Question 8

brain structures involved in anxiety d/os

Question 9

locus coerulus (what does it do?)

Answer 9

Locus coeruleus is involved in enhancing physiological responses to fear and panic

Question 10

where is there a high density of GABA receptors?

Answer 10

hippocampus

Question 11

barbituates

Question 12

non-barbituate sedatives

Question 13

flumazenil
(what does it do? used for?)

Answer 13

is a benzodiazepine antagonist

(used for benzo overdose)

Question 14

benzodiazepine SE

Answer 14

Sedation, ataxia, confusion, cognitive/motor impairment, amnesia

Especially problematic in children/adolescents and elderly

Some evidence that impairments are semi-permanent
High liability for

Question 15

what is the first choice of drugs for anxiety disorders?

Answer 15

SSRIs

Question 16

drug classes better/worse at treating PTSD/OCD?

Answer 16

SSRI especially good; benzos are not

Question 17

what is venlafaxine especially good for tmt of?

Answer 17

PD, social anx, GAD

Question 18

issues w venlafaxine

Answer 18

Can increase BP; not recommended in elderly
Higher toxicity risk than other SSNRIs

Question 19

beta blockers
(how do they work? primary use? psych uses? common ones?)

Answer 19

Block β-adrenergic receptors; decrease effects of epinephrine, NE, and cortisol

Primarily used to control cardiac arrhythmias and hypertension

Used most often for social
anxiety and performance anxiety

propanolol (Inderal)
atenolol (Tenormin)

Question 20

anxiety and nutrition

Question 21

how do benzodiazepines work?

Answer 21

Increases affinity of GABA binding site for GABA

GABAa agonist

Question 22

Unlike other anxiolytics, beta-blockers primarily work:

Answer 22

peripherally

Question 23

Drugs that reduce the activity of the _____________ seem to be particularly efficacious for treating Panic Disorder.

Answer 23

locus coerrulus

Question 24

The anticipatory anxiety experienced by people who have panic attacks can sometimes progress to

Answer 24

agoraphobia

Question 25

Venlafaxine is associated with a higher risk of ___________ in young (<24) patients.

Answer 25

suicide

Question 26

Alprazolam is contraindicated in patients who

Answer 26

smoke

Question 27

In addition to treating anxiety, Buspirone can be used to improve the ________________ side effects caused by SSRIs.

Answer 27

sexual

Question 28

One of the biggest problems with carbamazepine is that it can induce

Answer 28

agranularcytosis