Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PSYC475 psychopharm > antipsychotics > Flashcards

antipsychotics Flashcards

1
Q

paliperidone (trade name) is….

A

Invega

SGA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

xanomeline-trospium (trade name) is….

A

KarXT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

cariprazine (trade name) is….

A

Vraylar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

lumaterperone (trade name) is….

A

caplyta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the most problematic side effect of clozapine is….

A

agranularcytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

in general, antipsychotics have a _____ potential for dependence, and a ____ potential for tolerance

A

weak ; weak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

an off label use for risperidone is…

A

OCD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

the percentage of the world’s population suffering with schizophrenia is….

A

1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

examples of positive symptoms of schizophrenia

A

disordered thinking, hallucinations, delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

flat affect is a ______ symptom of schizophrenia

A

negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cariprazine should not be used by….

A

elderly patients with dementia-related psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

chloropromazine was originally develloped to be a….

A

sedative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

the word “tardive” in tardive dyskinesia indicates that….

A

the symptoms show up later in treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

the single best predictor of efficacy for an antipsychotic drug is an affinity for ____ receptors

A

D2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

loxapine is the only antipsychotic that …

A

is administered via inhalation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what class were the first antipsychotics

A

phenothiazines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

issues with FGAs

A

bad motor sx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

pharmacological causes of schizophrenia

A

dopamine hypothesis (too much DA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

phenothiazines binding profile

A

DA D2, AChM, H, NE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

EPS versus TD

A

EPS are reversible and have rapid onset ; TD is permanent and develops over time

21
Q

butyrophenones side effects

A

High incidence of EPS, particularly PD-like symptoms, dystonia, TD

Anticholinergic effects

Neuroleptic Malignant Syndrome (NMS)

22
Q

molindone / moban advantages

use?

A

induces weight loss

23
Q

what is pimozide (Orap) used for?

A

tourettes syndrome

24
Q

issues with pimozide (Orap)

A

higher incidence of cardia abnormalities

25
Q

common side effects of SGAs

A

“Metabolic Syndrome”

– Weight Gain
– Diabetes/Hyperglycemia
– Cardiac Abnormalities

26
Q

what are some of the SGAs?

A

Clozapine (Clozaril)
Olanzapine (Zyprexa)
Risperidone (Risperidol)
Sertindole (Serlect)
Quetiapine (Seroquel)
Ziprasidone (Geodon)
Aripiprazole (Abilify)
Amisulpride (Solian)

27
Q

Phenothiazines are in the class of antipsychotics known as

A

FGAs

28
Q

Amisulpiride is a good choice of antipsychotic for patients who have a high risk for

A

diabetes

29
Q

Cariprazine should not be used by

A

Elderly patients with dementia related psychosis

30
Q

What is the most common side effect of treatment with olanzapine

A

weight gain

31
Q

Chlorpromazine was originally developed to be a

A

sedative

32
Q

The major side effect of the first-generation antipsychotics is

A

motor impairment

33
Q

phenothiazines binding profile

A

Binding Profile: Primarily block DA D2, but also AChM1, H1, NEα1

– Blockade of AChM produces dry mouth, pupil dilation, blurry vision, cognitive impairment, constipation, urine retention, tachycardia (Sympathetic NS)

– H blockade produces sedation, antiemesis

– NE blockade produces sedation and hypotension

34
Q

phenothiazines sites of action (in brain)?4

A

– 1: Medulla
2: Limbic System/Frontal Lobes
3: hypothalamus
4: basal ganglia

35
Q

symptoms of Neuroleptic Malignant Syndrome (NMS); what drugs have this as a SE?

A

fever, muscle rigidity, autonomic fluctuations, alterations in consciousness.

phenothiazines

36
Q

QT prolongation occurs with what types of drugs?

A

SGAs

37
Q

diabetes occurs as a SE of ______

A

SGAs

38
Q

clozapine (trade name, drug class)

A

Clozaril ; SGA

39
Q

why was/is clozapine special?

A

reduces negative symptoms as well as positive sx ; effective in tmt resistant pts

40
Q

most serious SE of clozapine?

A

agranularcytosis

41
Q

olanzapine special because it is effective at _______

A

reducing negative symptoms

42
Q

sertindole is special because _______

A

Does not bind to H receptors, so no sedative effects

43
Q

_________ is a commonly abused SGA due to __________ and _____ effects

A

quetiapine (Seroquel) ; anxiolytic and sedative

44
Q

ziprasidone (Geodon) also has _________ and _______ actions, and may be used for treatment of ___________ disorder

A

antidepressant ; anxiolytic ; schizoaffective

45
Q

ziprasidone has a risk of __________

A

QT prolongation

46
Q

ziprasidone has the benefit of __________

A

low weight gain

47
Q

amprisulfride has the benefit of _________

A

low diabetogenic effects

48
Q

Chlorpromazine (Trade name; class of drug)

A

Thorazine

FGA

PSYC475 psychopharm (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions