cannabinoids Flashcards
THC can take up to 5 weeks to be completely excreted from the body because
it is highly lipid soluable
Hashish and marijuana differ mainly in their
potency
In California marijuana was legalized for non-medical use in
2016
3 off label uses for Epidolex
-pain relief
- anxiety
-management of ASD sx
In the US _______ states have legalized marijuana for either medical or recreational use.
46
The main ROA for dronabinol is
oral
In the US marijuana is currently listed under which DEA schedule?
I
Epidiolex is a ______________ at CB receptors.
partial agonist
The route of administration of Sativex is
oral mucosal spray
3 primary indications for dronabinol?
nausea/vomiting
appetite stimulation
anorexia
cannabis is distributed…..
highly lipid soluable ; concentrated in fat
cannabinoid receptors, specifially the CB1 are….
Possibly most populous receptor in the brain
2-5ng/mL of cannabis is associated with….
increased auto accidents
most common symptoms of cannabis withdrawal
irritability
LD50 for cannabis…
none known to humans
primary indication for rimonabant …. (2)
-Adjunct to diet and exercise in the treatment of obese patients with associated risk factors, i.e. type 2 diabetes, dyslipidaemia
-Marijuana dependence
rimonabant is important because….
First in class of therapeutic agents called cannabinoid 1-receptor blockers.
how does rimonabant work?
Inverse agonist for cannabinoid receptor CB-1
what is part of the reason THC has low toxicity
there are not many cannabinoid receptors in the brain stem. (receptors mostly in CNS)
what is the name of an endogenous cannabinoid
anandamide & 2AG
dronabinol is an
oral THC preparation
nabilone
cannabidiol
dronabinol trade name
Cesamet
Nabiximols is a …
non-synthetic cannabinoid agonist
A primary indication for cannabidiol is
seizure reduction
The route of administration of Sativex is
Oral mucosal spray
