cannabinoids

Question 1

THC can take up to 5 weeks to be completely excreted from the body because

Answer 1

it is highly lipid soluable

Question 2

Hashish and marijuana differ mainly in their

Answer 2

potency

Question 3

In California marijuana was legalized for non-medical use in

Answer 3

2016

Question 4

3 off label uses for Epidolex

Answer 4

-pain relief
- anxiety
-management of ASD sx

Question 5

In the US _______ states have legalized marijuana for either medical or recreational use.

Answer 5

46

Question 6

The main ROA for dronabinol is

Answer 6

oral

Question 7

In the US marijuana is currently listed under which DEA schedule?

Answer 7

I

Question 8

Epidiolex is a ______________ at CB receptors.

Answer 8

partial agonist

Question 9

The route of administration of Sativex is

Answer 9

oral mucosal spray

Question 10

3 primary indications for dronabinol?

Answer 10

nausea/vomiting
appetite stimulation
anorexia

Question 11

cannabis is distributed…..

Answer 11

highly lipid soluable ; concentrated in fat

Question 12

cannabinoid receptors, specifially the CB1 are….

Answer 12

Possibly most populous receptor in the brain

Question 13

2-5ng/mL of cannabis is associated with….

Answer 13

increased auto accidents

Question 14

most common symptoms of cannabis withdrawal

Answer 14

irritability

Question 15

LD50 for cannabis…

Answer 15

none known to humans

Question 16

primary indication for rimonabant …. (2)

Answer 16

-Adjunct to diet and exercise in the treatment of obese patients with associated risk factors, i.e. type 2 diabetes, dyslipidaemia

-Marijuana dependence

Question 17

rimonabant is important because….

Answer 17

First in class of therapeutic agents called cannabinoid 1-receptor blockers.

Question 18

how does rimonabant work?

Answer 18

Inverse agonist for cannabinoid receptor CB-1

Question 19

what is part of the reason THC has low toxicity

Answer 19

there are not many cannabinoid receptors in the brain stem. (receptors mostly in CNS)

Question 20

what is the name of an endogenous cannabinoid

Answer 20

anandamide & 2AG

Question 21

dronabinol is an

Answer 21

oral THC preparation

Question 22

nabilone

Question 23

cannabidiol

Question 24

dronabinol trade name

Answer 24

Cesamet

Question 25

Nabiximols is a …

Answer 25

non-synthetic cannabinoid agonist

Question 26

A primary indication for cannabidiol is

Answer 26

seizure reduction

Question 27

The route of administration of Sativex is

Answer 27

Oral mucosal spray