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PSYC475 psychopharm > bipolar drugs > Flashcards

bipolar drugs Flashcards

1
Q

quetiapine (trade name) is….

class of drug?

A

seroquel

SGA

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2
Q

lurasidone (trade name) is….
class of drug?

A

Latuda

SGA

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3
Q

ziprasidone (trade name) is….

class of drug?

A

Geodon

SGA

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4
Q

lamotrigine (trade name) is….

class of drug?

A

Lamictal

2nd gen anti-epileptic drug // phenyltriazine

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5
Q

the rate of suicide with people with bipolar disorder is ____x the general poulaiton

A

10 times

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6
Q

% prevalence worldwide of bipolar disorder

A

1%

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7
Q

diagnostic difficulties with bipolar disorder

A
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8
Q

who was the first person to use lithium for mania? what observation led to this use?

A

John Cade; seeing the lethagry it produced in rats

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9
Q

what was lithium originally used for?

A

gout , headaches, as a salt subsitute

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10
Q

TI for lithium

A

TI: 1.25-2.5 (very narrow)

basically will kill you by causing kidney failure

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11
Q

lithium side effects?

A

Neurological – tremor, lethargy, impaired concentration, dizziness, muscle weakness, nystagmus (repetitive, uncontrolled movement of eyes)

GI – nausea, vomiting, diarrhea, pain. Weight gain can be substantial.

Skin – rash, acne, psoriasis, hair loss, mucosal lesions, brittle nails

Thyroid – enlargement, goiter

Kidneys – increased thirst, increased urine output, renal failure

Cardiovascular – arrythmia

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12
Q

nystagmus is…..
this is associated with what drug?

A

(repetitive, uncontrolled movement of eyes)

SE of lithium

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13
Q

examples of anticonvulsants

A

Valproic Acid (valproate, Depakote)
Carbamazepine (Tegretol)
Oxcarbazepine (Trileptol)
Lamotrigine (Lamictal)
Gabapentin (Neurontin)
Pregabalin (Lyrica)
Topiramate (Topamax)
Zonisamide (Zonegran)
Tiagabine/retigabine

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14
Q

issues with anticonvulsants

A

teratogenic
inc suicidality

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15
Q

valproate (drug class and trade name)

A

depakote
anticonvulsant

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16
Q

**Valproate is better for _____ than lithium

A

mixed episodes

17
Q

carbamazepine (trade name)

class of drug?

A

Tegretol

anticonvulsant

18
Q

carbamazepine SE

most serious SE?

A

Side effects: cognitive impairments, GI upset, sedation, motor ataxia, leucopenia/agranulocytosis, skin reactions

most serious: leucopenia/agranulocytosis

19
Q

carbamazepine may be better than lithium for ______

A

rapid cyclers / mixed mania

20
Q

oxcarbazepine (trade name)

A

trileptal

21
Q

benefits of oxcarbezpine

A

Better safety index; no GI issues, no alterations in liver enzymes (fewer drug interactions), no leucopenia (no monitoring required)

22
Q

gabapentin / pregabalin (trade)

A

Neurontin, Lyrica

23
Q

benefits of gabapentin / pregabalin

A

Excellent safety profile; not metabolized by liver, excreted intact

24
Q

what was topiramate originally developed for?

A

anti-diabetes

25
Q

topiramate trade name

A

topamax

26
Q

benefits / considerations for topiramate?

A

Not super useful as a txt for BD, per se, however induces weight loss, which can counteract weight gain seen with other BD drugs

May increase lithium concentration in blood, so must monitor closely

27
Q

common atypical antipsychotics

A

risperidone (Risperdal)
olanzapine (Zyprexa)
olanzapine + fluoxetine = Symbyax
quetiapine (Seroquel)
aripiprazole (Abilify)
ziprasidone (Geodon)
lurasidone (Latuda)

28
Q

what is the first line of tmt for bipolar d/o?

A

atypical antipsychotics

29
Q

ability to reduce mania is correlated to________

A

affinity for D2 receptors

30
Q

STEP-BD study

A

~50% pxts achieved recovery, and ~50% of those pxts relapsed within 2 years
Residual symptoms at recovery, concurrent psychiatric diagnoses
Addition of an antidepressant did not give significantly better recovery rates
Valproate not recommended for female pxts (PCOS, teratogenic)
Lamotrigine is good for txt-resistant pxts
Psychosocial txt is very important for optimal recovery

31
Q

The uncontrollable movements of muscles commonly in the limbs, face, and tongue produced by ACUTE treatment with antipsychotics are called

A

dystonia

32
Q

risperidone trade name

drug class

A

(Risperdal)

SGA

33
Q

olanzapine trade name

drug class

A

(Zyprexa)

SGA

34
Q

Valproic Acid trade name

class?

A

(valproate, Depakote)

anticonvulsant

35
Q

Carbamazepine trade name? drug class?

A

(Tegretol)

anticonvulsant

36
Q

Topiramate trade name? drug class?

A

(Topamax)

anticonvulsant

37
Q

dystonia is….

A

The uncontrollable movements of muscles commonly in the limbs, face, and tongue produced by ACUTE treatment with antipsychotics

PSYC475 psychopharm (14 decks)

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