Paget's Disease Flashcards
1
Q
What is Paget’s disease?
A
Chronic disorder which results in thickened, brittle and mis-shapen bones
2
Q
Aetiology of paget’s disease?
A
- Viral infection
- Genetic defects
3
Q
Bones typically affected?
A
Pelvis Femur Skull Tibia Ear ossicles
4
Q
Symptoms of paget’s disease?
A
- Can be asymptomatic
- Arthritis
- Pathologic fractures
- Deformity
- Pain
- High output cardiac failure
5
Q
Investigations for Paget’s disease?
A
- Serum alkaline phosphatase is raised
- Calcium & phosphorous normal
- Radiograph shows the affected bone is enlarged, thickened cortices, coarse, and thickened trabeculae and mixed areas of lysis and sclerosis
6
Q
What would a radiograph show in Paget’s disease?
A
- Affected bone enlarged
- Thickened cortices
- Coarse, thickened trabeculae
- Mixed areas of lysis and sclerosis
7
Q
What do bone scans show for Paget’s disease?
A
Marked increase uptake in affected bones
8
Q
Treatment for Paget’s disease?
A
- Biphosphonates- inhibits osteoclasts
- Calcitonin
- Joint replacement may be necessary
- Pathological femoral fractures
9
Q
What doe biphosphonates do?
A
Inhibit osteoclasts
