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order
G1
G2
Mitosis
S
G1 S G2 M
G1 can go to G0
period of dna synthesis
and takes 7 hours
S
chomatin condenses within nucleus. mitotic spindles form
Prophase
nuc. membrane and nucleoli dissappear.
chromosome line up at equatrial plate of mitotic spindle
metaphase
chromssome spit
anaphase
telophase
nuclear membrane forms around chromosome at poles. Chromosomes uncoil and nucleoli reappear.
cytoplasm divided to 2 daughterr cells
produce 4 daughter cels with half chromosome number as parent cel.
meiosis
beltlike junction completely seals off intercellular space b/n cells
tight junction(zonula occludens)
int. junction
beltlike junction leaving 15-20 nm wide intercellullar space b/n adjacent cells
desmosome
provide strong but localized adhesion sites b/n adjacent cells.
composed of attachment plaque on cytoplasic side of each adjoining cell surface to which intermediate filaments anchored,
cel-cell (band)
tight junction
int. junction
cell-cell(focal)
desmosome
hemidesmosome
gap junction
adhesion is function
int. junction
desmosome
hemidesmosome
occlusion
tight junction
gap junction
communication
occludens and claudin
princ. proteins of tight juntion
actin, cadherin
int. junction
cadherin
desmosome
integrin
hemidesmosome
connexin
gap junction
various ep.
Tight junction
Int. junction
neurons
Smooth and
cardiac muscle
gap junction
epidermis and other ep
desmosome
eputhelium and oral mucosa
hemidesmosome
provide strong but localized attachment of ep cells to CT.
desmosome
gap junction
localized area of free commnication b/n adjacent cells.
enables passage of fluid , ions, and small mol.
receptors
sec. component of gland
lines body cavity
covers body surface
epithelium
barre
diffusion
absorption
secretory
transport
sensory
functions of ep
one layer thick , touching Basement mebrane
simple
2 or more cell layer thick, deepest touching basement membrane
stratified ep.
pseudostratified ep.
one cell layer thick
all touch basement membrane
not all reach outer layer
columnar
absorption, secretion, transport
simple columnar
presudostratified
simple squamous
barrier diffusion
barrier secretion, absorption
simple cuboidal
barrier
strat. sq
barrier secretion
strat cuboidal
barrier transport
strat columnar
barrier distension
transitional
width > height
squamous ep.
width =height
cuboidal ep
height> width
columnar
ranges form squamous to cuboidal
distensible
transitional ep
line BV
endothelium
mesothelium
line all closd bode cavities
connect ep basal layer to CT
Basement membrane
attachment s
separation
filtration
scaffolding
functions ofBM
components of Basement memrbane
electron clear layer
type 4 colagen
proteoglycans
laminin
fibronectin
anchor fibrils
lamanin densa
reticular lamina
ret. fibers(type 3 collagen)
specialized CT
adipose tissue
blood
bone
cartieldge
lymphatic tissue
hematopoetic tissue
mesenchyme
mucus Ct
embryonic CT
loost CT
dense CT(reg and irreg)
CT proper
bone to bone
ligament
muscle to bone
tendon
aponeurosis
a sheetlike tendon
sharpeys fiber
proton of lig. or tendon insert into bone or cementum
loose CT
abundant ground substance with sparse fibers an cells
located under ep layer that cover body surface and line body cavity
> fiber concentration, providing structural support
dense CT
irregular Dense Ct
irregular arrangemnt of fbers and cells
majority of dense CT
dermis
submucosa of GI
fibrous capsule
irregular dense CT
ordered rrangement of fibers and cells
i
redular dense Ct
tendon
lig
aponeurosis
regular Dense Ct
resident cell pop.
fibroblast(most common)
myofibroblast
adipocytes
macrophage
mast cell
mesenchymal cells
transient cell pop
lymphocyte
neutrophil
monocyte
plasma cells
eosinophils
basophils
secete product thru duct
exocrine
sweat saliva sebum
digestive enzymes
exocrine glands
endocrine glands
secrete products into bloodstream
secrete various peptides
paracrine
unicell and multicell
single sec unit vs multiple
goblet vs gastric cells
single vs. multiple sec units
merocrine
secretory producrt released from secretory granules
major salivary glands, panc. acinar cells
merocrine
apocrine
secretoyr product relased with cytoplasm
mamm gland, apocrine
sweat gland
apocrine gland
holocrine gland
secretory products released with porton of cell
ex. is sebacious gland
simple duct structure
unbranched
ex. is sweat gland
compound
branched
ex. major salivary glands and pancreas
tubular secretoyr unit
secretory portion shaped like a tube
ext. intestinal glans
colied secretory unit
secretory portion shaped like a coiled tube
ex. is eccrine sweat gland
acinar gland
secretory portion shaped lke sac like dilation
tubuloacinar glands
combo of tubular and acinar
ex. major salivary glands
mucus
viscous secretion
ex. subling salivary glands
goblet cells
mucus
h2o secretion
serous
parotid salivary gland
von ebner sal gland
paneth cells
gastric chief cells
serous secretion
mixed secretion
combo of mucus and secretion
ex. is submand saliary gland
structure of sal glands
lobes subdivided by CT septa
sal gland
lobe–> lobules–> terminal secretory units
contain cell seceting glycoprotein
and H2O elements of saliva
terminal sec. unit
lined with simple cub. ep
terminal secretory unit
secretory
serous and mucus cells
contractile cells
myoep cells
intercalated ducts
transports salva to larger duct
lined with simple cub. ep.
striated ducts
modifies salivary electrolyte
numerous elong. mitochondria give striatd appearance
lined by simple low columnar ep
striated ducts
terminal exc. duct
transports saliva to oral cavity
lined by presudostrat. columnar ep.
terminal exc. duct
avasc. CT
blood supply from pericondirum
cartiledge
compsoed of condrocytes
and reside in lacunae
and surrounded by own specialized ECM
cartieldge
chondroblasts
initial cartilagenic cellls
cartieldge matrix
type 2 collagen
ground substance ; hydrophillic
cartiledg matrix
ground substance of cartieldge matrix
GAGS; hyaluronic acid, chondroitin sulfate, keratin sulfate
proteoglycan
GAGS
make up ground substance of Cart. matrix
innr cell layer of perichondrium
makes chondroblast
provides protection
outer fibrous layer of cartiledge
appositional growth
new cartiledge forms on surface of existing cartiledg
have perichondirum
fibroblastic cells from inner perichondrium differentiate into chondroblast–> secrete matrix
appo. growth of cartiledge
nw cart. from existing cart.
interstitial growth
chondrocyte divide within lacunae enable new matric to be deposited
interstitial growth
some perichondriumm
with close packed thin collagen fibers
hyaline
perichondrium
coll. and elastic fibers
elastic
no perichondrium
dense collagen fibers
fibrocartiledge
provide elastic properties
elastic cartieldge
withstand compression and tension
fibrocartiledge
provides pliability and resilience
precursor to end. bone formation
hyaline
can calcify
hyaline
nose trachea bronchi
larynx
ribs
art. surface of long bones
hyaline
elastic cart.
ext. ear
eus. tube
epiglottis
IVD
art disc of TMJ
symphysis pubic
meniscus of knee
fibrocartiledge
cant calcify
elastic and fibrocartieldge
yellow minerlaized vasc tissue of varying degree density
bone
osteoblast
make osteoid;type 1 collagen and ground substance
mature bone form when osteoid calcifies
calc. process
osteoblast trapped in spaces within min. matrix called lacunae and diff,. to osteocyte
osteocyte
maintain bone matrix
maintain nourishment via vasc. tunnels within bones called canaliculi.
function of bone
support
protection
movemnet
mineral storage, Ca,P
bonemarrow; hematopoesis
osteoclacin;
marker of bone formation
one component of bone matrix
binds CA and collagen
osteonectin
GAG
ground substance
hydroxyapetite
inorganic component of bone matrix
occurs in both end. and intermembranous bone at anytime
appositional growth
occurs in endochondral bone only until epiphyseal plate coses
interstitial growth
mes. cells diff into osteoblast
- > secrete bone matrix within established locus of loose arranged collagen.
new matrix calcifies to form immature woven bone
over time, osteoclastic resorption of woven bone and new osteoblast matrix is deposited in more tight arranged manner
matrix calcified to form mature bone of high strength
Int. ossification
flat bone of skull
maxilla
mand. body
clavicle
int. ossification
endochondral oss.
subperiosteal bony cuff forms around already established locus of hyaline cartiledge.
grows larger and causes hypertrophy and death of chondrocyte
cartledge matric calcifies
over time, osteoclastic resorption of calcified cartiledg occurs and new osteoblastic matrix deposited to form mature bone
long bone
vertebrae
mand. condyles
end. ossification
occurs in both end. and intermembranous oss at any time
appositional growth
occurs in endochondral bone only until epiphyseal plates close
interstitial growth
cortical bone
haversian system
concentric bone matrix lamellae surrounding cnetral hav canal containing neurovasc. bundles
caniliculi connect to the central canal by volksmans canal
space b/n osteon is omposed of previous osteonal lamellae called interstitial lamellae
haversian system description
cancellous bone
is lamellar like cortical bone
config, and arrangement is less dense.
lamellae of cancellous bone
thin spicules called trabeculae
if thick enuf contain osteons
(b/n trabeculae are marrow spaces of various sizes)
trabeculae follow line of stress
periosteum
fibrous CT capsule surorunding outer surface bone
collagne fibroblast
osteoprogenitor cells
periosteum
one cell layer thick mostly of osteoprogenitor cells that line inner surface bone.
has bone marrow
endosteum
yellow marrow
fat cells
predominat emarrow type in maxilla and mandible
hemapoeitic cells
found in mand. ramus and condyles
red marrow
multi nuc. giant cell that reside in resorption bays known as howship lacunae
osteoclast
make large number of hydrolytic nzymes from ruffled border
osteoclast
proton lower pH at site of resorption, subsequently dissolving calc. bone matrix
after collegnases and proteases digest decalc. bone matrix
osteoclast
fracture repair
blood clot forms
bridging callus formation
periosteal callus formation
new end. bone formation
PTH
stim. osteoclastic bone resorption
sec. by parathyroid gland
calcitonin
inh. osteoclastic bone resorption
sec. by parafolllicular cells of tyroid gland
immovable joint
synarthrosis
ampiarthrosis
slightly movablejoint
diarthosis
fully moveable joint
joined by firbous CT
fibrous CT
suture
(cranial)
radius ulna
tibia fibula
syndesmosis
tooth socket
gomphosis
cartilagenous
joined by cartiledge
synchondrosis
epiphyseal plate of long bone
symhysis pubis
symphysis
synovial
freely movable
lined by synovial membrane
majority of joints
synovial joint