•Overview of the liver Flashcards
Liver functions
-regulation of protein, carbohydrate and lipid metabolism -regulation of cholesterol production and excretion -β-oxidation of fatty acids -bile acid production -degradation of hormones -detoxification and excretion of drugs and toxins -vitamin storage
_____ of blood comes into the liver from the hepatic artery
450 ml/min
_____ of blood comes into the liver from the portal vein
1 liter/min
the pressure in the hepatic vein is under _____
1 mmHg
interstitial space between parenchymal hepatocytes where lymph is secreted:
space of Disse
canals that bile flows through:
bile canaliculi
the hallmark obstructive liver disease is ____, which is characterized by ____
cirrhosis, scarring
ascites formation
increased hepatic vein pressure —> pooling of blood in liver capillaries—> increased capillary hydrostatic pressure —> increased transudation of fluid from plasma and space of Disse into the peritoneal cavity of the abdomen forming ascites
because lymphatics are also involved, in ascites, you get ____ in the fluid
proteins
if you have minor ascites, the _____ can absorb fluid to take care of it
greater omentum
there is normally ____ of blood in the liver. In hepatomegaly, the liver can increase to ____
400 ml, 1 L
jaundice
yellowing of skin and eyes from excess bilirubin in the blood
bilirubin is a product of ___
RBC metabolism
obstructive jaundice
obstruct the ability of bile to be made or secreted so it ends up in the blood instead- cirrhosis, gallstones, biliary atresia, cancer
hepatic jaundice
can result from acute or chronic hepatitis, reduces the ability of the hepatic cells to metabolize bilirubin. ex. alcoholic hepatitis