GI Secretions 1 and 2 - combo 1/17 Flashcards

Recheck hormones (first half)

1
Q

3 glands that contribute to Saliva

A

• Parotid Glands - serious fluid (contains amylase) • Submaxillary glands - mixed serous/mucous fluid • Sublingual glands - mucous fluids

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2
Q

Secretin promotes ____, inhibits ______

A

promotes — pancreatic bicarb secretions and an alkaline pH in the duodenum (high pH) inhibits — gastric acid secretion (acid is low pH)

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3
Q

CCK decreases ______, increases secretion of _______ and ______

A

decreases gastric emptying, and increases pancreatic enzyme secretion, and bile secretion (gall bladder contractions)

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4
Q

VIP

A

VasoACTIVE intestinal Polypep – “active” – it increases intestinal motility.

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5
Q

______ is the only hormone that promotes GASTRIC functions (acid secretion and motility)

A

Gastrin — promotes gastric acid secretion and motility

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6
Q

Alkaline Tide

A

HCO3- / Cl - Exchanger

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7
Q

apical surface of the parietal cells have ____

A

proton pumps

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8
Q

as salivary flow increases, the osmolality ____ due to a _____

A

increases, decrease in the reabsorption of electrolytes

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9
Q

CCK

A

CCK is released from the duodenum as soon as chyme enters into it (due to vagal stimulation) - causes the release of digestive enzymes and bile from pancreas and gallbladder

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10
Q

cephalic phase

A
  • sensory activation (sight, smell), anticipatory response - Glossopharyngeal and facial nerves – increase saliva production - Vagus (Ach) – stimulates parietal cells to secrete HCl to prepare stomach for food (before it gets there)
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11
Q

Changes in GIT due to fever

A
  • increasing GI contractions, pushing chyme out of tract faster, and decrease absorption - metabolic rate goes up
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12
Q

Co-lipase

A

makes the lipids accessible to the pancreatic lipase

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13
Q

Colon Secretions

A

reabsorb all of the remaining Na+ and Cl-

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14
Q

enterokinase

A

trypsinogen to trypsin

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15
Q

gastric phase

A

stretch and gastrin release

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16
Q

GIP: GIP stands for 2 things

A

a. Gastric inhibitory polypeptide: inhibit gastric acid secretion. b. Glucose dependent insulinotropic polypeptide.

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17
Q

H. pylori

A

natural resistance to our gastric acid protective mucus barrier

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18
Q

how does chloride come into the lumen?

A

HCO3- is exchanged for Cl-

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19
Q

how is H+ made?

A

the metabolism of CO2, the bicarbonate is secreted into the blood resulting in an alkaline tide

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20
Q

if you reduce blood flow to a gland, you reduce _____

A

the ability of the gland to secrete

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21
Q

if you stimulate the ____, you get a tremendous increase in salivary flow. If you stimulate the ____, you don’t get much of an increase in flow

A

parasympathetics inc salivary flow sympathetic stimulation would not increase flow

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22
Q

in addition to GI peptides, ____ is produced in adipose tissues and is a counterpart of ghrelin. It decreases appetite by suppressing ____

A

leptin, NPY

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23
Q

in the fasting state, ____ is secreted into the blood from _____ cells in the stomach

A

ghrelin, oxnytic (parietal)

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24
Q

in the ____ of the hypothalamus, ghrelin stimulates ____, an orexigenic peptide which stimulates a sense of ___

A

arcuate nucleus, NPY, hunger

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25
Q

intestinal phase

A

vagal reflex and then inhibitory local ENS reflex

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26
Q

Jejunum and Ileum

A

bulk reabsorption of all of those electrolytes we’ve been secreting

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27
Q

NO – nitric oxide

A

–ultimate smooth muscle relaxer, so it reduces motility and relaxes sphincters.

28
Q

NPY hormone

A

stimulates HUNGER.

29
Q

parietal cells

A

canaliculi

30
Q

Peptic ulcer

A

inflammation causes mucosal damage

31
Q

Peptide YY and GLP-1

A
  • promote satiety as chyme moves through intestines - surpasses both gastric and pancreatic secretion (by suppressing Ach and stimulating somatostatin) - released from ilium??
32
Q

you can tell from its name that this hormone also promotes intestinal motility.

A

Motilin!

33
Q

saliva is always ____ to plasma

A

hypotonic

34
Q

satiety is a result of many different GI peptides, including ____. They suppress ____, decreasing appetite

A

peptide YY and GLP-1 (glucagon-like peptide) hypothalamic NPY

35
Q

the amount of acid that is made is determined by ____

A

the number of pumps inserted into the membrane

36
Q

the concentration of H+ in the lumen is ____x higher than in the cell

A

10^6

37
Q

the concentration of K+ in saliva is about ___ whereas the concentration in the plasma is about ___

A

20 mEq/L, 4

38
Q

the parotid glands secrete:

A

serous fluid w/ amylase

39
Q

the sublingual glands secrete:

A

mucous fluid

40
Q

the submaxillary glands secrete:

A

mixed serous/mucous fluid

41
Q

This is the only hormone that causes gallbladder contraction.

A

CKK: “cholecyst” = gallbladder, “kinin” = move. – gall bladder –> bile secretion, important for lipid digestion. Also important for lipid digestion– Pancreatic lipase! CKK increases secretion of Pancreatic enzymes. ** CKK decreases gastric emptying.**

42
Q

Vagus efferents, Gastrin, and Histamine

A

stimulating gastric acid secretion

43
Q

What are the 7 functions of saliva?

A

“COLD TAP” coagulation factors oral hygiene lubrication digestion taste antimicrobial protection

44
Q

what are the gastric secretions?

A

HIPGLaHMS _HCl- chemical digestion (parietal) _Intrinsic factor (IF)- protect B12 (parietal) _Pepsinogen- digests proteins (chief) _Gastrin- HCl secretagogue (G-cells in antrum) _Lipase- lipid digestion (chief) _Histamine - increase HCl _Mucus- protection _SS - suppress HCl

45
Q

what are the three paired saliva glands?

A

parotid glands submaxillary glands sublingual glands

46
Q

What controls flow of Saliva?

A

PNS glossopharyngeal and facial nerves

47
Q

What controls salivary flow? If you severed these nerves, what happens?

A
  • PNS controls flow of saliva through glossopharyngeal and facial nerves - without these nerves salivary glands would atrophy
48
Q

what enzymes are found in saliva and what do they do?

A

α-amylase: for starch digestion lingual lipase: lipid digestion (more important in babies) R-binders (proteins): bind and protect B12 from proteases in the stomach

49
Q

what happens to metabolic rate in fever?

A

it goes up

50
Q

What inhibits all secretion, does not affect motility– the “inhibitory hormone”?

A

Somatostatin: [somato-stat stops secretions, and is static]

– inhibits all secretions (acid, pepsinogen, HCO3-, pancreatic enzymes, insulin, glucagon).

– It does not affect motility.

51
Q

What is the “anticipatory reaction”?

A

increased gastric acid secretion

52
Q

what things decrease salivary flow?

A

“SAD - ADHD’S” sympathetics (NE) aging Dehydration ADH, Aldo (hormones) Drugs Sleep

53
Q

what things increase salivary flow?

A

parasympathetics (Ach) CNS (cephalic phase) nausea esophageal distension (bolus!) chewy, flavorful foods dry, acidic, alkaline foods meats, sweets, bitter foods

54
Q

α-Amylase

A

digest starch molecules

55
Q

4 Hormones that affect the stomach:

A

” Get Caught Seretin Gastrin”

GIP, CKK, Secretin, Gastrin

56
Q

The inhibitory hormone

A

Somatostatin

57
Q

3 Hormones that affect intestinal motility:

A

NO, VIP, and Motilin

58
Q

Stomach distension increases motility of the stomach via _____ and intestine via_____

A

increases motility of the stomach (via Gastrin) and intestine (via VIP).

* When the stomach’s full, you want the food to move along to the next part of the GIT.

59
Q

when the stomach is too acidic, you’ll want to bring the pH back to normal by decreasing acid secretion, by …..

A
  • DEC Gastrin = dec acid secretion
  • INC secretin + Somatostatin = dec acid secretion
60
Q

when there’s glucose in your GIT, you’ll want to get ready for it by having insulin available, which is done via ____

A

GIP

61
Q

fatty acids increase the secretion of

A

CCK, GIP, Secretin

** fatty acids are digested by pancreatic lipases which require an alkaline pH to function**

62
Q

Both amino acids and fatty acids increase the secretion of ____ and _____.

A

CCK and GIP.

63
Q

Amino acids also increase secretion of these 3 things:

A

“CGG” = CCK, GIP, Gastrin

[think: proteins are digested by pepsin, acid makes pepsinogen into pepsin, need acid!]

64
Q

Vagal stimulation increases ___ and ___, decreases ____________.

A
  • INC – Gastrin and VIP
  • dec – Somatostatin
65
Q
  • Chief of Pepsi-Cola
  • PARI
A

Chief cells of stomach produce Pepsin

Parietal cells Produce Acid & Release Intrinsic factor

66
Q

4 mneumonics

A
  1. Lesser OMentum holds Liver and stOMach
  2. Mesentery holds the sMall intestine
  3. mesoCOLON attaches COLON to posterior abdominal wall.
  4. e. coLI is found in the Large Intestine