GI Secretions 1 and 2 - combo 1/17 Flashcards
Recheck hormones (first half)
3 glands that contribute to Saliva
• Parotid Glands - serious fluid (contains amylase) • Submaxillary glands - mixed serous/mucous fluid • Sublingual glands - mucous fluids
Secretin promotes ____, inhibits ______
promotes — pancreatic bicarb secretions and an alkaline pH in the duodenum (high pH) inhibits — gastric acid secretion (acid is low pH)
CCK decreases ______, increases secretion of _______ and ______
decreases gastric emptying, and increases pancreatic enzyme secretion, and bile secretion (gall bladder contractions)
VIP
VasoACTIVE intestinal Polypep – “active” – it increases intestinal motility.
______ is the only hormone that promotes GASTRIC functions (acid secretion and motility)
Gastrin — promotes gastric acid secretion and motility
Alkaline Tide
HCO3- / Cl - Exchanger
apical surface of the parietal cells have ____
proton pumps
as salivary flow increases, the osmolality ____ due to a _____
increases, decrease in the reabsorption of electrolytes
CCK
CCK is released from the duodenum as soon as chyme enters into it (due to vagal stimulation) - causes the release of digestive enzymes and bile from pancreas and gallbladder
cephalic phase
- sensory activation (sight, smell), anticipatory response - Glossopharyngeal and facial nerves – increase saliva production - Vagus (Ach) – stimulates parietal cells to secrete HCl to prepare stomach for food (before it gets there)
Changes in GIT due to fever
- increasing GI contractions, pushing chyme out of tract faster, and decrease absorption - metabolic rate goes up
Co-lipase
makes the lipids accessible to the pancreatic lipase
Colon Secretions
reabsorb all of the remaining Na+ and Cl-
enterokinase
trypsinogen to trypsin
gastric phase
stretch and gastrin release
GIP: GIP stands for 2 things
a. Gastric inhibitory polypeptide: inhibit gastric acid secretion. b. Glucose dependent insulinotropic polypeptide.
H. pylori
natural resistance to our gastric acid protective mucus barrier
how does chloride come into the lumen?
HCO3- is exchanged for Cl-
how is H+ made?
the metabolism of CO2, the bicarbonate is secreted into the blood resulting in an alkaline tide
if you reduce blood flow to a gland, you reduce _____
the ability of the gland to secrete
if you stimulate the ____, you get a tremendous increase in salivary flow. If you stimulate the ____, you don’t get much of an increase in flow
parasympathetics inc salivary flow sympathetic stimulation would not increase flow
in addition to GI peptides, ____ is produced in adipose tissues and is a counterpart of ghrelin. It decreases appetite by suppressing ____
leptin, NPY
in the fasting state, ____ is secreted into the blood from _____ cells in the stomach
ghrelin, oxnytic (parietal)
in the ____ of the hypothalamus, ghrelin stimulates ____, an orexigenic peptide which stimulates a sense of ___
arcuate nucleus, NPY, hunger
intestinal phase
vagal reflex and then inhibitory local ENS reflex
Jejunum and Ileum
bulk reabsorption of all of those electrolytes we’ve been secreting