Overview in defense against microbes 1 Flashcards
lecture 26-27
microbes does the immune system respond to?
bacteria, extracellular/intracellular (facultative/obligatory)
fungi, extracellular/intracellular
viruses
parasites, protozoan(unicellular)intracellular/extracellular and metazoan(multicellular)
tumors or malignant cells
what immune cells respond to extracellular pathogens?
CD4+ T cell response and humoral immune response
what immune cells response to intracellular pathogens?
CD8+ T cell response, CD4+ TH1 response
what immune cells respond to metazoan parasites?
Th2 type response
this is a field of immunology which results in an immune response against the microbe rather than the microbe itself; collateral damage
immunopathology
outline the immune response steps?
breach in barrier entry of pathogen initial inflammation recognition of PAMPs by PRRs of innate immune cells, innate immune cells active cytokines/chemokines recruitment of inflammatory cells inflammation activation of APCs different cytokine mileau adaptive immune response control of infection