Direct/Indirect effects of NOS

Question 1

host cell apoptosis
autophagosomal degradation of bacteria
Fpn1-mediated iron deprivation
phagolysosomal fusion
inhibition of the expression of bacterial effectors/toxins/adhsions
dispersion of bacterial biofilms
immunoregulatory effects

Answer 1

indirect antimicrobial effects of NO

Question 2

inhibition of pathogen proliferation
DNA mutagenesis
disruption of FeS clusters
metabolic blockade (krebs cycle)
inactivation of virulence factors

Answer 2

direct antimicrobial effects of NO

Question 3

these damage the bacterial membrane

Answer 3

electrically charged proteins

Question 4

break down the cell wall

Answer 4

lysozyme

Question 5

these are from neutrophil granules that remove essential iron from bacteria

Answer 5

lactoferrins

Question 6

this is a broad spectrum serine protease that kills many types of bacteria and found in neutrophils

Answer 6

elastase

Question 7

plays an important role in eliminating intracellular pathogens and breaking down tissues at inflammatory sites, as well as in anti-inflammatory respons

Answer 7

cathepsin G

Question 8

digest bacterial proteins

Answer 8

proteases and hydrolytic enzymes